{"id":42818,"date":"2020-07-06T06:30:51","date_gmt":"2020-07-06T06:30:51","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=42818"},"modified":"2020-07-05T14:42:13","modified_gmt":"2020-07-05T14:42:13","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-triptolide-induce-la-inhibicion-del-crecimiento-y-la-apoptosis-de-las-celulas-de-laringocarcinoma-humano-al-mejorar-las-activid","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42818","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abTriptolide induce la inhibici\u00f3n del crecimiento y la apoptosis de las c\u00e9lulas de laringocarcinoma humano al mejorar las actividades de p53 y suprimir la degradaci\u00f3n de p53 mediada por E6\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-B2s31VnN-4Q\/XwHkph8U49I\/AAAAAAAAeKc\/6c3iHKdiqmoFAgDs8ZXraNzgMMYXwaavgCLcBGAsYHQ\/s1600\/PLOS_ONE.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-B2s31VnN-4Q\/XwHkph8U49I\/AAAAAAAAeKc\/6c3iHKdiqmoFAgDs8ZXraNzgMMYXwaavgCLcBGAsYHQ\/s1600\/PLOS_ONE.jpg\" border=\"0\" data-original-width=\"262\" data-original-height=\"317\" \/><\/a>Zhao, F., Huang, W., Ousman, T., Zhang, B., Han, Y., Clotaire, D. Z. J., &#8230; &amp; Lei, M. (2013).\u00a0<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0080784\">Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation.<\/a>\u00a0<i>PloS one<\/i>, 8(11), e80784.<\/p>\n<p>FONDO \/ OBJETIVO: Triptolide, un compuesto activo extra\u00eddo de la hierba china Leigongteng ( Tripterygium wilfordii Hook F.), muestra un amplio espectro de actividad anticancer\u00edgena a trav\u00e9s de su citotoxicidad. Sin embargo, la eficacia de triptolida en el laringocarcinoma rara vez se ha evaluado, y el mecanismo por el cual la apoptosis celular inducida por triptolida a\u00fan no se conoce bien.<\/p>\n<p>RESULTADOS: En este estudio, encontramos que triptolida inhib\u00eda significativamente la proliferaci\u00f3n, migraci\u00f3n y supervivencia de las c\u00e9lulas de laringocarcinoma HEp-2. Triptolide induce la detenci\u00f3n del ciclo celular HEp-2 en la fase G1 y la apoptosis a trav\u00e9s de v\u00edas intr\u00ednsecas y extr\u00ednsecas, ya que tanto la caspasa-8 como la -9 est\u00e1n activadas. Adem\u00e1s, triptolida aumenta la expresi\u00f3n de p53 al aumentar su estabilidad a trav\u00e9s de la regulaci\u00f3n negativa de E6 y E6AP. El aumento de p53 transactiva los genes objetivo aguas abajo para iniciar la apoptosis. Adem\u00e1s, encontramos que el tratamiento a corto plazo con da\u00f1o de ADN inducido por triptolida, que fue consistente con el aumento de p53. Adem\u00e1s, la citotoxicidad de triptolida se reduce por la eliminaci\u00f3n de p53 o el uso de inhibidor de caspasas.<\/p>\n<p>CONCLUSI\u00d3N: En conclusi\u00f3n, nuestros resultados demostraron que triptolida inhibe la proliferaci\u00f3n celular e induce la apoptosis en las c\u00e9lulas de laringocarcinoma al mejorar la expresi\u00f3n de p53 y activar las funciones de p53 a trav\u00e9s de la inducci\u00f3n de da\u00f1o en el ADN y la supresi\u00f3n de la degradaci\u00f3n de p53 mediada por E6. Estos estudios indican que el triptolide es un f\u00e1rmaco potencial contra el laringocarcinoma. nuestros resultados demostraron que triptolida inhibe la proliferaci\u00f3n celular e induce apoptosis en las c\u00e9lulas de laringocarcinoma al mejorar la expresi\u00f3n de p53 y activar las funciones de p53 a trav\u00e9s de la inducci\u00f3n de da\u00f1o en el ADN y la supresi\u00f3n de la degradaci\u00f3n de p53 mediada por E6.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhao, F., Huang, W., Ousman, T., Zhang, B., Han, Y., Clotaire, D. Z. J., &#8230; &amp; Lei, M. (2013).\u00a0Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation.\u00a0PloS one, 8(11), e80784. FONDO \/ OBJETIVO: Triptolide, un compuesto activo extra\u00eddo de la hierba china Leigongteng ( Tripterygium [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42818","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Triptolide induce la inhibici\u00f3n del crecimiento y la apoptosis de las c\u00e9lulas de laringocarcinoma humano al mejorar las actividades de p53 y suprimir la degradaci\u00f3n de p53 mediada por E6&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42818\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Triptolide induce la inhibici\u00f3n del crecimiento y la apoptosis de las c\u00e9lulas de laringocarcinoma humano al mejorar las actividades de p53 y suprimir la degradaci\u00f3n de p53 mediada por E6&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zhao, F., Huang, W., Ousman, T., Zhang, B., Han, Y., Clotaire, D. Z. J., &#8230; &amp; Lei, M. (2013).\u00a0Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation.\u00a0PloS one, 8(11), e80784. FONDO \/ OBJETIVO: Triptolide, un compuesto activo extra\u00eddo de la hierba china Leigongteng ( Tripterygium [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42818\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-06T06:30:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-05T14:42:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-B2s31VnN-4Q\/XwHkph8U49I\/AAAAAAAAeKc\/6c3iHKdiqmoFAgDs8ZXraNzgMMYXwaavgCLcBGAsYHQ\/s1600\/PLOS_ONE.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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