{"id":42892,"date":"2020-07-09T04:30:41","date_gmt":"2020-07-09T04:30:41","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=42892"},"modified":"2020-07-09T20:13:31","modified_gmt":"2020-07-09T20:13:31","slug":"42892","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42892","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfectos condroprotectores del celastrol sobre la osteoartritis a trav\u00e9s de la activaci\u00f3n de la autofagia y la inhibici\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n de NF-\u03baB\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-4_VpM0RGCuQ\/Xwd560rVgJI\/AAAAAAAAeRU\/yQl4jwzHJ2oEOfb-fNeHI7bdK78M3zMfgCLcBGAsYHQ\/s1600\/Inflammation_Research.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-4_VpM0RGCuQ\/Xwd560rVgJI\/AAAAAAAAeRU\/yQl4jwzHJ2oEOfb-fNeHI7bdK78M3zMfgCLcBGAsYHQ\/s1600\/Inflammation_Research.jpg\" border=\"0\" data-original-width=\"153\" data-original-height=\"204\" \/><\/a>Feng, K., Chen, H., &amp; Xu, C. (2020).\u00a0<a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs00011-020-01327-z\">Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-\u03baB signaling pathway inhibition.<\/a>\u00a0<i>Inflammation Research<\/i>, 1-16.<\/p>\n<p>OBJETIVO:\u00a0La osteoartritis (OA) es una enfermedad degenerativa del cart\u00edlago articular acompa\u00f1ada de apoptosis superflua de condrocitos en los ancianos. Celastrol es una potente medicina bioactiva que puede ejercer efectos antiinflamatorios y antioxidantes en diversas enfermedades. Este estudio tuvo como objetivo dilucidar el posible papel del celastrol en la OA, as\u00ed como el mecanismo espec\u00edfico de celastrol in vitro e in vivo.<\/p>\n<p>M\u00c9TODOS:\u00a0Los biomarcadores relacionados con la autofagia y las mol\u00e9culas apopt\u00f3ticas se evaluaron mediante PCR, Western blot y tinci\u00f3n con inmunofluorescencia. El nivel de autofagia se evalu\u00f3 mediante tinci\u00f3n con MDC y microscop\u00eda electr\u00f3nica de transmisi\u00f3n. Para estudiar la ruta de se\u00f1alizaci\u00f3n aguas abajo, las prote\u00ednas relacionadas con la ruta de se\u00f1alizaci\u00f3n del factor nuclear kappa B (NF-\u03baB) se examinaron mediante transferencia Western. Adem\u00e1s, se estableci\u00f3 un modelo de rata con transecci\u00f3n del ligamento cruzado anterior (ACLT) para observar el efecto protector del celastrol sobre el cart\u00edlago de la rata.<\/p>\n<div>\n<p>RESULTADOS:\u00a0Encontramos que celastrol mejor\u00f3 la apoptosis de condrocitos inducida por IL-1\u03b2 y aument\u00f3 la expresi\u00f3n de LC3-II y Beclin-1. Adem\u00e1s, la supresi\u00f3n de la autofagia inducida por el celastrol por 3-metiladenina (3MA) evit\u00f3 el efecto protector del celastrol en los condrocitos. Adem\u00e1s, el celastrol disminuy\u00f3 el grado de fosforilaci\u00f3n estimulada por IL-1\u03b2 de I\u03baB\u03b1 y P65. Tambi\u00e9n encontramos que PDTC (un conocido inhibidor de la v\u00eda NF-\u03baB) puede promover la activaci\u00f3n de la autofagia y atenuar la apoptosis de los condrocitos. Mientras tanto, los resultados del modelo ACLT de rata revelaron el mismo efecto que los experimentos in vitro.<\/p>\n<p>CONCLUSIONES:\u00a0En resumen, el celastrol protege contra la apoptosis de los condrocitos al promover la autofagia e inhibir la v\u00eda de se\u00f1alizaci\u00f3n de NF-\u03baB in vitro e in vivo.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Feng, K., Chen, H., &amp; Xu, C. (2020).\u00a0Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-\u03baB signaling pathway inhibition.\u00a0Inflammation Research, 1-16. OBJETIVO:\u00a0La osteoartritis (OA) es una enfermedad degenerativa del cart\u00edlago articular acompa\u00f1ada de apoptosis superflua de condrocitos en los ancianos. Celastrol es una potente medicina bioactiva que puede ejercer efectos antiinflamatorios y antioxidantes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42892","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos condroprotectores del celastrol sobre la osteoartritis a trav\u00e9s de la activaci\u00f3n de la autofagia y la inhibici\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n de NF-\u03baB&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42892\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos condroprotectores del celastrol sobre la osteoartritis a trav\u00e9s de la activaci\u00f3n de la autofagia y la inhibici\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n de NF-\u03baB&quot; -\" \/>\n<meta property=\"og:description\" content=\"Feng, K., Chen, H., &amp; Xu, C. (2020).\u00a0Chondro-protective effects of celastrol on osteoarthritis through autophagy activation and NF-\u03baB signaling pathway inhibition.\u00a0Inflammation Research, 1-16. OBJETIVO:\u00a0La osteoartritis (OA) es una enfermedad degenerativa del cart\u00edlago articular acompa\u00f1ada de apoptosis superflua de condrocitos en los ancianos. Celastrol es una potente medicina bioactiva que puede ejercer efectos antiinflamatorios y antioxidantes [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=42892\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-09T04:30:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-09T20:13:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-4_VpM0RGCuQ\/Xwd560rVgJI\/AAAAAAAAeRU\/yQl4jwzHJ2oEOfb-fNeHI7bdK78M3zMfgCLcBGAsYHQ\/s1600\/Inflammation_Research.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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