{"id":42902,"date":"2020-07-08T02:30:22","date_gmt":"2020-07-08T00:30:22","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=42902"},"modified":"2020-07-09T23:45:16","modified_gmt":"2020-07-09T21:45:16","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-tratamiento-de-la-obesidad-con-celastrol","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=42902","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abTratamiento de la obesidad con celastrol\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-E5BWUL_DS1c\/XwePdxzFZdI\/AAAAAAAAeSM\/zjbQsaIPwm83hkHyKrSqChwQCB7v1lYWwCLcBGAsYHQ\/s1600\/Cell.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-E5BWUL_DS1c\/XwePdxzFZdI\/AAAAAAAAeSM\/zjbQsaIPwm83hkHyKrSqChwQCB7v1lYWwCLcBGAsYHQ\/s320\/Cell.jpg\" width=\"246\" height=\"320\" border=\"0\" data-original-width=\"591\" data-original-height=\"768\" \/><\/a>Liu, J., Lee, J., Hernandez, M. A. S., Mazitschek, R., &amp; Ozcan, U. (2015).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867415005590\">Treatment of obesity with celastrol<\/a>.\u00a0<i>Cell<\/i>, 161(5), 999-1011.<\/p>\n<p>A pesar de todos los avances modernos en medicina, todav\u00eda no se ha encontrado un tratamiento farmacol\u00f3gico eficaz contra la obesidad. El descubrimiento de la leptina hace dos d\u00e9cadas cre\u00f3 esperanzas para el tratamiento de la obesidad. Sin embargo, el desarrollo de resistencia a la leptina ha sido un gran obst\u00e1culo, ya que mitiga un tratamiento de la obesidad centrado en la leptina.<\/p>\n<p>Aqu\u00ed, al usar m\u00e9todos de detecci\u00f3n de drogas in silico, descubrimos que Celastrol , un triterpeno pentac\u00edclico extra\u00eddo de las ra\u00edces de la planta Tripterygium Wilfordi (enredadera del dios del trueno), es un poderoso agente contra la obesidad. Celastrol suprime la ingesta de alimentos, bloquea la reducci\u00f3n del gasto de energ\u00eda y conduce a una p\u00e9rdida de peso de hasta el 45%en ratones obesos inducidos por dieta hiperleptin\u00e9mica (DIO) al aumentar la sensibilidad a la leptina, pero es ineficaz en modelos de ratones con deficiencia de leptina ( ob \/ ob ) y deficiente de receptor de leptina ( db \/ db) .<\/p>\n<p>Estos resultados indican que Celastrol es un sensibilizador de leptina y un agente prometedor para el tratamiento farmacol\u00f3gico de la obesidad.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liu, J., Lee, J., Hernandez, M. A. S., Mazitschek, R., &amp; Ozcan, U. (2015).\u00a0Treatment of obesity with celastrol.\u00a0Cell, 161(5), 999-1011. A pesar de todos los avances modernos en medicina, todav\u00eda no se ha encontrado un tratamiento farmacol\u00f3gico eficaz contra la obesidad. El descubrimiento de la leptina hace dos d\u00e9cadas cre\u00f3 esperanzas para el tratamiento de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-42902","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Tratamiento de la obesidad con celastrol&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=42902\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Tratamiento de la obesidad con celastrol&quot; -\" \/>\n<meta property=\"og:description\" content=\"Liu, J., Lee, J., Hernandez, M. 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