{"id":43039,"date":"2020-07-18T03:30:05","date_gmt":"2020-07-18T01:30:05","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43039"},"modified":"2020-07-19T19:42:38","modified_gmt":"2020-07-19T17:42:38","slug":"43039","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43039","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfecto del resveratrol sobre el desarrollo de tumores mamarios espont\u00e1neos en ratones transg\u00e9nicos HER-2 \/ neu\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-ON_xR1jP3hw\/XxSFYTuACXI\/AAAAAAAAegs\/CGzh9cqqQc4D0gPNu0DcQmFvtcfX-n9egCLcBGAsYHQ\/s1600\/International_Journal%2Bof%2BCancer.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-ON_xR1jP3hw\/XxSFYTuACXI\/AAAAAAAAegs\/CGzh9cqqQc4D0gPNu0DcQmFvtcfX-n9egCLcBGAsYHQ\/s320\/International_Journal%2Bof%2BCancer.jpg\" width=\"243\" height=\"320\" border=\"0\" data-original-width=\"666\" data-original-height=\"875\" \/><\/a>Provinciali, M., Re, F., Donnini, A., Orlando, F., Bartozzi, B., Di Stasio, G., &amp; Smorlesi, A. (2005).\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.20874\">Effect of resveratrol on the development of spontaneous mammary tumors in HER\u20102\/neu transgenic mice<\/a>.\u00a0<i>International journal of cancer<\/i>, 115(1), 36-45.<\/p>\n<p>FONDO: Se ha informado que el resveratrol (Res) posee actividad quimiopreventiva del c\u00e1ncer sobre la base de sus efectos in vitro sobre las c\u00e9lulas tumorales y los modelos experimentales in vivo de roedores trasplantados con tumores parentales o tratados con carcin\u00f3genos.<\/p>\n<p>OBJETIVO: Investigamos los efectos de Res en el desarrollo de tumores mamarios que aparecen espont\u00e1neamente en ratones transg\u00e9nicos HER-2 \/ neu a una edad temprana.<\/p>\n<p>M\u00c9TODO: Los mecanismos implicados en el efecto antitumoral de Res se evaluaron mediante el estudio de la efectividad inmune, la apoptosis tumoral y la expresi\u00f3n de ARNm y prote\u00edna para HER-2 \/ neu en las gl\u00e1ndulas mamarias tumorales de ratones tratados con Res y en l\u00edneas celulares tumorales.<\/p>\n<p>RESULTADOS: La suplementaci\u00f3n con Res retras\u00f3 el desarrollo de tumores mamarios espont\u00e1neos (p &lt;0,001), redujo el n\u00famero medio y el tama\u00f1o de los tumores mamarios (p &lt;0. 0001) y disminuy\u00f3 el n\u00famero de met\u00e1stasis pulmonares en ratones transg\u00e9nicos HER-2 \/ neu. Los efectos de Res se asociaron con la regulaci\u00f3n negativa de la expresi\u00f3n del gen HER-2 \/ neu y el aumento de la apoptosis tanto en las gl\u00e1ndulas tumorales mamarias como en las l\u00edneas celulares tumorales murinas (N202) y humanas (SKBr3). Ni la actividad NK basal, inducida por IL-2 ni el n\u00famero de linfocitos y la proliferaci\u00f3n se modificaron en ratones suplementados con Res en comparaci\u00f3n con los ratones control.<\/p>\n<p>CONCLUSI\u00d3N: Nuestros resultados demuestran que la suplementaci\u00f3n con Res retrasa el desarrollo y reduce la capacidad de met\u00e1stasis de los tumores mamarios espont\u00e1neos en ratones transg\u00e9nicos HER-2 \/ neu. El efecto antitumoral de Res podr\u00eda estar relacionado con la regulaci\u00f3n negativa de la expresi\u00f3n de HER-2 \/ neu y la inducci\u00f3n de apoptosis en las c\u00e9lulas tumorales.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Provinciali, M., Re, F., Donnini, A., Orlando, F., Bartozzi, B., Di Stasio, G., &amp; Smorlesi, A. (2005).\u00a0Effect of resveratrol on the development of spontaneous mammary tumors in HER\u20102\/neu transgenic mice.\u00a0International journal of cancer, 115(1), 36-45. FONDO: Se ha informado que el resveratrol (Res) posee actividad quimiopreventiva del c\u00e1ncer sobre la base de sus efectos in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-43039","post","type-post","status-publish","format-standard","hentry","category-naturopatia-fitocomplementaria-herbologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto del resveratrol sobre el desarrollo de tumores mamarios espont\u00e1neos en ratones transg\u00e9nicos HER-2 \/ neu&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43039\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto del resveratrol sobre el desarrollo de tumores mamarios espont\u00e1neos en ratones transg\u00e9nicos HER-2 \/ neu&quot; -\" \/>\n<meta property=\"og:description\" content=\"Provinciali, M., Re, F., Donnini, A., Orlando, F., Bartozzi, B., Di Stasio, G., &amp; Smorlesi, A. (2005).\u00a0Effect of resveratrol on the development of spontaneous mammary tumors in HER\u20102\/neu transgenic mice.\u00a0International journal of cancer, 115(1), 36-45. FONDO: Se ha informado que el resveratrol (Res) posee actividad quimiopreventiva del c\u00e1ncer sobre la base de sus efectos in [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43039\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-18T01:30:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-19T17:42:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-ON_xR1jP3hw\/XxSFYTuACXI\/AAAAAAAAegs\/CGzh9cqqQc4D0gPNu0DcQmFvtcfX-n9egCLcBGAsYHQ\/s320\/International_Journal%2Bof%2BCancer.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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