{"id":43061,"date":"2020-07-20T03:30:42","date_gmt":"2020-07-20T01:30:42","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43061"},"modified":"2020-07-20T14:08:13","modified_gmt":"2020-07-20T12:08:13","slug":"43061","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43061","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfectos antiagregaci\u00f3n de los compuestos fen\u00f3licos en la \u03b1-sinucle\u00edna\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-jKWeHFAmdsg\/XxWIvPKExYI\/AAAAAAAAeh0\/J-vXlhLBQsAtCuOycasy3BYWcoPAZK2ggCLcBGAsYHQ\/s1600\/Molecules.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-jKWeHFAmdsg\/XxWIvPKExYI\/AAAAAAAAeh0\/J-vXlhLBQsAtCuOycasy3BYWcoPAZK2ggCLcBGAsYHQ\/s320\/Molecules.jpg\" width=\"222\" height=\"320\" border=\"0\" data-original-width=\"303\" data-original-height=\"435\" \/><\/a>Ono, K., Tsuji, M., Yamasaki, T. R., &amp; Pasinetti, G. M. (2020).\u00a0<a href=\"https:\/\/scholar.google.com\/scholar_url?url=https:\/\/www.mdpi.com\/1420-3049\/25\/10\/2444\/pdf&amp;hl=es&amp;sa=T&amp;oi=gsb-gga&amp;ct=res&amp;cd=0&amp;d=12623705828069521438&amp;ei=3ocVX4aKLYGNy9YPnP2x8AE&amp;scisig=AAGBfm0GQrdIF2qYQWZUyaUoWSM-kTsutQ\">Anti-aggregation Effects of Phenolic Compounds on \u03b1-synuclein<\/a>.\u00a0<i>Molecules<\/i>, 25(10), 2444.<\/p>\n<p>La agregaci\u00f3n y el dep\u00f3sito de \u03b1-sinucle\u00edna (\u03b1S) son caracter\u00edsticas patol\u00f3gicas importantes de la enfermedad de Parkinson, la demencia con cuerpos de Lewy y otras sinucleinopat\u00edas \u03b1. La propagaci\u00f3n de la patolog\u00eda \u03b1S \u200b\u200ben el cerebro juega un papel clave en el inicio y la progresi\u00f3n de los fenotipos cl\u00ednicos. Por lo tanto, existe un inter\u00e9s creciente en desarrollar estrategias que aten\u00faen la agregaci\u00f3n y propagaci\u00f3n de \u03b1S.<\/p>\n<p>En base a la evidencia acumulada de que los olig\u00f3meros \u03b1S son especies neurot\u00f3xicas y cr\u00edticas en la patog\u00e9nesis de las sinucleinopat\u00edas \u03b1, nosotros y otros grupos informamos que los compuestos fen\u00f3licos inhiben la agregaci\u00f3n de \u03b1S, incluida la oligomerizaci\u00f3n, mejorando as\u00ed las toxicidades celulares y sin\u00e1pticas inducidas por olig\u00f3meros \u03b1S. La heterogeneidad en la microbiota intestinal puede influir en la eficacia del metabolismo de polifenoles en la dieta.<\/p>\n<p>Nuestros estudios recientes sobre los \u00e1cidos polifen\u00f3licos penetrantes en el cerebro \u00e1cido 3-hidroxibenzoico (3-HBA), \u00e1cido 3,4-dihidroxibenzoico (3,4-diHBA) y \u00e1cido 3-hidroxifenilac\u00e9tico (3-HPPA), que se derivan del intestino El metabolismo de los polifenoles de la dieta basado en microbiota demostr\u00f3 una capacidad in vitro para inhibir la oligomerizaci\u00f3n de \u03b1S y mediar la neurotoxicidad inducida por \u03b1S agregada. Adem\u00e1s, el \u00e1cido 3-HPPA, 3,4-diHBA, 3-HBA y 4-hidroxibenzoico atenuaron significativamente la agregaci\u00f3n de siembra \u03b1S intracelular en un sistema basado en c\u00e9lulas.<\/p>\n<p>Esta revisi\u00f3n se centra en los desarrollos de investigaciones recientes con respecto a las propiedades neuroprotectoras, especialmente los efectos de agregaci\u00f3n anti-\u03b1S, de los compuestos fen\u00f3licos y sus metabolitos por el microbioma intestinal, incluidos nuestros hallazgos en la patog\u00e9nesis de las sinucleinopat\u00edas \u03b1. y el \u00e1cido 3-hidroxifenilac\u00e9tico (3-HPPA), que se derivan del metabolismo intestinal de los polifenoles de la dieta basados \u200b\u200ben microbiota, demostraron una capacidad in vitro para inhibir la oligomerizaci\u00f3n de \u03b1S y mediar la neurotoxicidad inducida por \u03b1S agregada.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ono, K., Tsuji, M., Yamasaki, T. R., &amp; Pasinetti, G. M. (2020).\u00a0Anti-aggregation Effects of Phenolic Compounds on \u03b1-synuclein.\u00a0Molecules, 25(10), 2444. La agregaci\u00f3n y el dep\u00f3sito de \u03b1-sinucle\u00edna (\u03b1S) son caracter\u00edsticas patol\u00f3gicas importantes de la enfermedad de Parkinson, la demencia con cuerpos de Lewy y otras sinucleinopat\u00edas \u03b1. La propagaci\u00f3n de la patolog\u00eda \u03b1S \u200b\u200ben el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-43061","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos antiagregaci\u00f3n de los compuestos fen\u00f3licos en la \u03b1-sinucle\u00edna&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43061\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efectos antiagregaci\u00f3n de los compuestos fen\u00f3licos en la \u03b1-sinucle\u00edna&quot; -\" \/>\n<meta property=\"og:description\" content=\"Ono, K., Tsuji, M., Yamasaki, T. R., &amp; Pasinetti, G. M. (2020).\u00a0Anti-aggregation Effects of Phenolic Compounds on \u03b1-synuclein.\u00a0Molecules, 25(10), 2444. La agregaci\u00f3n y el dep\u00f3sito de \u03b1-sinucle\u00edna (\u03b1S) son caracter\u00edsticas patol\u00f3gicas importantes de la enfermedad de Parkinson, la demencia con cuerpos de Lewy y otras sinucleinopat\u00edas \u03b1. La propagaci\u00f3n de la patolog\u00eda \u03b1S \u200b\u200ben el [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43061\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-20T01:30:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-20T12:08:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-jKWeHFAmdsg\/XxWIvPKExYI\/AAAAAAAAeh0\/J-vXlhLBQsAtCuOycasy3BYWcoPAZK2ggCLcBGAsYHQ\/s320\/Molecules.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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fen\u00f3licos en la \u03b1-sinucle\u00edna\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=43061","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Efectos antiagregaci\u00f3n de los compuestos fen\u00f3licos en la \u03b1-sinucle\u00edna\" -","og_description":"Ono, K., Tsuji, M., Yamasaki, T. R., &amp; Pasinetti, G. M. (2020).\u00a0Anti-aggregation Effects of Phenolic Compounds on \u03b1-synuclein.\u00a0Molecules, 25(10), 2444. La agregaci\u00f3n y el dep\u00f3sito de \u03b1-sinucle\u00edna (\u03b1S) son caracter\u00edsticas patol\u00f3gicas importantes de la enfermedad de Parkinson, la demencia con cuerpos de Lewy y otras sinucleinopat\u00edas \u03b1. 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