{"id":43153,"date":"2020-07-24T00:30:50","date_gmt":"2020-07-23T22:30:50","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43153"},"modified":"2020-07-26T10:36:48","modified_gmt":"2020-07-26T08:36:48","slug":"43153","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43153","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abAislamiento de fracciones ricas en antocianinas de fresa y sus mecanismos de acci\u00f3n contra l\u00edneas celulares de c\u00e1ncer de mama murino\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-l2FBDQYJ7aQ\/Xx0_6md8wdI\/AAAAAAAAep0\/kzrdLx1y04cJ5LohH6E8e1aPcl4z0HLfgCLcBGAsYHQ\/s1600\/Food_Function.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-l2FBDQYJ7aQ\/Xx0_6md8wdI\/AAAAAAAAep0\/kzrdLx1y04cJ5LohH6E8e1aPcl4z0HLfgCLcBGAsYHQ\/s320\/Food_Function.png\" width=\"245\" height=\"320\" border=\"0\" data-original-width=\"733\" data-original-height=\"955\" \/><\/a>Mazzoni, L., Giampieri, F., Suarez, J. M. A., Gasparrini, M., Mezzetti, B., Hernandez, T. Y. F., &amp; Battino, M. A. (2019).\u00a0<a href=\"https:\/\/pubs.rsc.org\/--\/content\/articlehtml\/2019\/fo\/c9fo01721f\">Isolation of strawberry anthocyanin-rich fractions and their mechanisms of action against murine breast cancer cell lines<\/a>.\u00a0<i>Food &amp; Function<\/i>, 10(11), 7103-7120.<\/p>\n<p>OBJETIVO: El objetivo de este estudio fue la evaluaci\u00f3n de los efectos del tratamiento con extracto de antocianina de fresa en dos modelos in vitro de l\u00edneas celulares de c\u00e1ncer de mama murino, en un intento de detectar una v\u00eda espec\u00edfica (prote\u00edna quinasa activada por AMP o AMPK) a trav\u00e9s de la cual las fresas ejercen su actividad anticancer\u00edgena.<\/p>\n<p>METODO: Se evalu\u00f3 la actividad anticancer\u00edgena de los extractos de antocianinas purificadas de un cultivar Alba en dos l\u00edneas celulares de c\u00e1ncer murino, N202 \/ 1A (con altos niveles del oncog\u00e9n HER2 \/ neu) y N202 \/ 1E (con bajos niveles del oncog\u00e9n HER2 \/ neu). despu\u00e9s de 48 y 72 h de tratamiento. Se evaluaron la viabilidad celular y la apoptosis, las tasas de ROS intracelular y el da\u00f1o oxidativo celular. Se realizaron ensayos de Western blot para analizar la expresi\u00f3n de varias prote\u00ednas relacionadas con la apoptosis, la autofagia, la met\u00e1stasis, el estado oxidativo, la funcionalidad mitocondrial y la v\u00eda AMPK.<\/p>\n<p>RESULTADOS: Este estudio demostr\u00f3 que el extracto de antocianina de fresa Alba muestra un efecto antiproliferativo sobre las c\u00e9lulas cancerosas, a trav\u00e9s de la inducci\u00f3n de apoptosis y estr\u00e9s oxidativo, al estimular diferentes v\u00edas moleculares. Este estudio es uno de los primeros estudios que han tratado de profundizar la comprensi\u00f3n de una v\u00eda candidata para la explicaci\u00f3n de los efectos de la fresa en las c\u00e9lulas cancerosas.<\/p>\n<p>CONCLUSI\u00d3N: Se demostr\u00f3 una relaci\u00f3n entre la v\u00eda AMPK y los efectos anticancer\u00edgenos de las fresas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mazzoni, L., Giampieri, F., Suarez, J. M. A., Gasparrini, M., Mezzetti, B., Hernandez, T. Y. F., &amp; Battino, M. A. (2019).\u00a0Isolation of strawberry anthocyanin-rich fractions and their mechanisms of action against murine breast cancer cell lines.\u00a0Food &amp; Function, 10(11), 7103-7120. OBJETIVO: El objetivo de este estudio fue la evaluaci\u00f3n de los efectos del tratamiento con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-43153","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;Aislamiento de fracciones ricas en antocianinas de fresa y sus mecanismos de acci\u00f3n contra l\u00edneas celulares de c\u00e1ncer de mama murino&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43153\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;Aislamiento de fracciones ricas en antocianinas de fresa y sus mecanismos de acci\u00f3n contra l\u00edneas celulares de c\u00e1ncer de mama murino&quot; -\" \/>\n<meta property=\"og:description\" content=\"Mazzoni, L., Giampieri, F., Suarez, J. M. A., Gasparrini, M., Mezzetti, B., Hernandez, T. Y. F., &amp; Battino, M. A. (2019).\u00a0Isolation of strawberry anthocyanin-rich fractions and their mechanisms of action against murine breast cancer cell lines.\u00a0Food &amp; Function, 10(11), 7103-7120. 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