{"id":43162,"date":"2020-07-24T03:30:57","date_gmt":"2020-07-24T01:30:57","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43162"},"modified":"2020-07-26T13:02:21","modified_gmt":"2020-07-26T11:02:21","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-las-mitocondrias-en-la-neuroproteccion-por-fitoquimicos-los-polifenoles-bioactivos-modulan-el-sistema-la-funcion-y-la-estruct","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43162","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLas mitocondrias en la neuroprotecci\u00f3n por fitoqu\u00edmicos: los polifenoles bioactivos modulan el sistema, la funci\u00f3n y la estructura de la apoptosis mitocondrial\u00bb"},"content":{"rendered":"

<\/a>Naoi, M., Wu, Y., Shamoto-Nagai, M., & Maruyama, W. (2019).\u00a0Mitochondria in neuroprotection by phytochemicals: bioactive polyphenols modulate mitochondrial apoptosis system, function and structure<\/a>.\u00a0International journal of molecular sciences<\/i>, 20(10), 2451.<\/p>\n

En el envejecimiento y las enfermedades neurodegenerativas, la p\u00e9rdida de distintos tipos de neuronas caracteriza las caracter\u00edsticas patol\u00f3gicas y cl\u00ednicas espec\u00edficas de la enfermedad, y las mitocondrias juegan un papel fundamental en la supervivencia y muerte neuronal. Las mitocondrias ahora se consideran los org\u00e1nulos para modular las v\u00edas y funciones de la se\u00f1al celular, no solo para producir energ\u00eda y especies reactivas de ox\u00edgeno.<\/p>\n

El estr\u00e9s oxidativo, el d\u00e9ficit de factores neurotr\u00f3ficos y muchos otros factores deterioran la funci\u00f3n mitocondrial e inducen la muerte celular. Los polifenoles de plantas multifuncionales, los principales grupos de fitoqu\u00edmicos, se proponen como uno de los medicamentos m\u00e1s prometedores dirigidos a las mitocondrias para preservar la actividad y la estructura de las mitocondrias y las neuronas.<\/p>\n

Los polifenoles pueden eliminar las especies reactivas de ox\u00edgeno y nitr\u00f3geno y activar los factores de transcripci\u00f3n responsables de redox para regular la expresi\u00f3n de genes, codificar antioxidantes, la familia de prote\u00ednas anti-apopt\u00f3ticas Bcl-2 y factores neurotr\u00f3ficos pro-supervivencia. En las mitocondrias, los polifenoles pueden regular directamente el sistema de apoptosis mitocondrial, ya sea para prevenir o promover. Los polifenoles tambi\u00e9n modulan la biog\u00e9nesis mitocondrial, la din\u00e1mica (fisi\u00f3n y fusi\u00f3n) y la degradaci\u00f3n autof\u00e1gica para mantener la calidad y el n\u00famero.<\/p>\n

Esta revisi\u00f3n presenta el papel de los polifenoles en la regulaci\u00f3n del estado redox mitocondrial, el sistema de se\u00f1ales de muerte y la homeostasis. Las propiedades redox dualistas de los polifenoles est\u00e1n asociadas con la controvertida regulaci\u00f3n del sistema de apoptosis mitocondrial involucrado en las funciones neuroprotectoras y anticancer\u00edgenas. Los derivados fitoqu\u00edmicos dirigidos a las mitocondrias se sintetizaron en base a la estructura fen\u00f3lica para desarrollar una nueva serie de compuestos neuroprotectores y anticancer\u00edgenos, que promueven la biodisponibilidad y la eficacia.<\/p>\n

Los fitoqu\u00edmicos han demostrado los m\u00faltiples efectos beneficiosos en las mitocondrias, pero se requiere m\u00e1s investigaci\u00f3n para la aplicaci\u00f3n cl\u00ednica.<\/p>\n","protected":false},"excerpt":{"rendered":"

Naoi, M., Wu, Y., Shamoto-Nagai, M., & Maruyama, W. (2019).\u00a0Mitochondria in neuroprotection by phytochemicals: bioactive polyphenols modulate mitochondrial apoptosis system, function and structure.\u00a0International journal of molecular sciences, 20(10), 2451. En el envejecimiento y las enfermedades neurodegenerativas, la p\u00e9rdida de distintos tipos de neuronas caracteriza las caracter\u00edsticas patol\u00f3gicas y cl\u00ednicas espec\u00edficas de la enfermedad, y las […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-43162","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "Las mitocondrias en la neuroprotecci\u00f3n por fitoqu\u00edmicos: los polifenoles bioactivos modulan el sistema, la funci\u00f3n y la estructura de la apoptosis mitocondrial" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43162\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "Las mitocondrias en la neuroprotecci\u00f3n por fitoqu\u00edmicos: los polifenoles bioactivos modulan el sistema, la funci\u00f3n y la estructura de la apoptosis mitocondrial" -\" \/>\n<meta property=\"og:description\" content=\"Naoi, M., Wu, Y., Shamoto-Nagai, M., & Maruyama, W. (2019).\u00a0Mitochondria in neuroprotection by phytochemicals: bioactive polyphenols modulate mitochondrial apoptosis system, function and structure.\u00a0International journal of molecular sciences, 20(10), 2451. En el envejecimiento y las enfermedades neurodegenerativas, la p\u00e9rdida de distintos tipos de neuronas caracteriza las caracter\u00edsticas patol\u00f3gicas y cl\u00ednicas espec\u00edficas de la enfermedad, y las […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43162\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-24T01:30:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-26T11:02:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-NbMAOo0ycyA\/Xx1iP9RfD5I\/AAAAAAAAeqM\/t5VcTqypLro69-5C8NGMBbviXs4YoYhJACLcBGAsYHQ\/s320\/International_Journal%2Bof%2BMolecular%2BSciences.JPG\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" 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