{"id":43167,"date":"2020-07-24T05:30:14","date_gmt":"2020-07-24T03:30:14","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43167"},"modified":"2020-07-26T15:10:50","modified_gmt":"2020-07-26T13:10:50","slug":"43167","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43167","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl resveratrol y la quercetina, dos polifenoles naturales, reducen la muerte celular neuronal apopt\u00f3tica inducida por la neuroinflamaci\u00f3n\u00bb"},"content":{"rendered":"

<\/a>Bureau, G., Longpr\u00e9, F., & Martinoli, M. G. (2008).\u00a0Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation<\/a>.\u00a0Journal of neuroscience research<\/i>, 86(2), 403-410.<\/p>\n

CONTEXTO: La enfermedad de Parkinson (EP) es un trastorno del movimiento caracterizado por una p\u00e9rdida progresiva de neuronas dopamin\u00e9rgicas nigroestriatales. La activaci\u00f3n de la microgl\u00eda y la neuroinflamaci\u00f3n se han asociado con la patog\u00e9nesis de la EP. De hecho, las citocinas se han propuesto como candidatos que median la muerte celular apopt\u00f3tica de las neuronas dopamin\u00e9rgicas observadas en la EP.<\/p>\n

OBJETIVO: En este estudio, investigamos el efecto de dos polifenoles naturales, el resveratrol y la quercetina, en la neuroinflamaci\u00f3n.<\/p>\n

M\u00c9TODO \/ RESULTADOS: Para las c\u00e9lulas gliales, observamos que los niveles de ARNm inducidos por lipopolisac\u00e1rido (LPS) de dos genes proinflamatorios, interleucina 1-alfa y factor de necrosis tumoral alfa, disminuyen fuertemente con los tratamientos con resveratrol o quercetina. Tambi\u00e9n realizamos un cocultivo microglial-neuronal para examinar la influencia del resveratrol y la quercetina en la muerte celular neuronal dopamin\u00e9rgica provocada por la microglia activada por LPS. Se realizaron ensayos de citotoxicidad para evaluar el porcentaje de muerte celular, con c\u00e9lulas apopt\u00f3ticas identificadas tanto por la t\u00e9cnica de marcaje de extremos de dUTP mediada por TdT como por la detecci\u00f3n de caspasa-3 escindida.<\/p>\n

Informamos que el tratamiento de las c\u00e9lulas microgliales N9 con resveratrol o quercetina redujo con \u00e9xito la muerte apopt\u00f3tica mediada por inflamaci\u00f3n de las c\u00e9lulas neuronales en nuestro sistema de cocultivo.<\/p>\n

CONCLUSI\u00d3N: En conjunto, nuestros resultados demuestran que el resveratrol y la quercetina disminuyeron la muerte celular neuronal apopt\u00f3tica inducida por la activaci\u00f3n microglial y sugieren que estos dos fitoestr\u00f3genos pueden ser compuestos antiinflamatorios potentes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Bureau, G., Longpr\u00e9, F., & Martinoli, M. G. (2008).\u00a0Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation.\u00a0Journal of neuroscience research, 86(2), 403-410. CONTEXTO: La enfermedad de Parkinson (EP) es un trastorno del movimiento caracterizado por una p\u00e9rdida progresiva de neuronas dopamin\u00e9rgicas nigroestriatales. La activaci\u00f3n de la microgl\u00eda y la neuroinflamaci\u00f3n […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-43167","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "El resveratrol y la quercetina, dos polifenoles naturales, reducen la muerte celular neuronal apopt\u00f3tica inducida por la neuroinflamaci\u00f3n" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43167\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "El resveratrol y la quercetina, dos polifenoles naturales, reducen la muerte celular neuronal apopt\u00f3tica inducida por la neuroinflamaci\u00f3n" -\" \/>\n<meta property=\"og:description\" content=\"Bureau, G., Longpr\u00e9, F., & Martinoli, M. G. (2008).\u00a0Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation.\u00a0Journal of neuroscience research, 86(2), 403-410. CONTEXTO: La enfermedad de Parkinson (EP) es un trastorno del movimiento caracterizado por una p\u00e9rdida progresiva de neuronas dopamin\u00e9rgicas nigroestriatales. La activaci\u00f3n de la microgl\u00eda y la neuroinflamaci\u00f3n […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43167\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-24T03:30:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-07-26T13:10:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-adkUYFU6-Xk\/Xx2AYhnf0UI\/AAAAAAAAeqs\/J0RML8Ss5dIuD8di33q0OysATdVWmA-pQCLcBGAsYHQ\/s1600\/Journal_Neuroscience%2BResearch.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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