{"id":43287,"date":"2020-07-31T00:30:53","date_gmt":"2020-07-30T22:30:53","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43287"},"modified":"2020-07-31T10:48:35","modified_gmt":"2020-07-31T08:48:35","slug":"43287","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43287","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abEl microbioma intestinal cambia el p53 mutante de supresor tumoral a oncog\u00e9nico\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-ySlVzEMYeNU\/XyPabA3mDsI\/AAAAAAAAezA\/4-Exl1_XGGALYzTi-BrCTgcQXqnyAFJbACLcBGAsYHQ\/s1600\/Nature.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-ySlVzEMYeNU\/XyPabA3mDsI\/AAAAAAAAezA\/4-Exl1_XGGALYzTi-BrCTgcQXqnyAFJbACLcBGAsYHQ\/s320\/Nature.jpg\" width=\"241\" height=\"320\" border=\"0\" data-original-width=\"340\" data-original-height=\"451\" \/><\/a>Kadosh, E., Snir-Alkalay, I., Venkatachalam, A. et al.\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2541-0\">The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic<\/a>.<i>\u00a0Nature<\/i>\u00a0(2020). https:\/\/doi.org\/10.1038\/s41586-020-2541-0<\/p>\n<p>Las mutaciones som\u00e1ticas en p53, que inactivan la funci\u00f3n supresora de tumores de p53 y a menudo confieren propiedades de ganancia de funci\u00f3n oncog\u00e9nicas, son muy comunes en el c\u00e1ncer.<\/p>\n<p>Aqu\u00ed estudiamos los efectos de las mutaciones de ganancia de funci\u00f3n de hotspot en Trp53 (el gen que codifica p53 en ratones) en modelos de rat\u00f3n de c\u00e1ncer intestinal impulsado por WNT causado por la deleci\u00f3n Csnk1a1 o la mutaci\u00f3n Apc Min. Se sabe que el c\u00e1ncer en estos modelos se ve facilitado por la p\u00e9rdida de p53.<\/p>\n<p>Encontramos que las versiones mutantes de p53 ten\u00edan efectos contrastantes en diferentes segmentos del intestino: en el intestino distal, el p53 mutante ten\u00eda el efecto oncog\u00e9nico esperado; sin embargo, en el intestino proximal y en los organoides tumorales tuvo un pronunciado efecto supresor tumoral. En el modo supresor de tumores, el p53 mutante elimin\u00f3 la displasia y la tumorig\u00e9nesis en Csnk1a1- deficiente y Apc Min \/ +ratones, y promovi\u00f3 el crecimiento normal y la diferenciaci\u00f3n de los organoides tumorales derivados de estos ratones.<\/p>\n<p>En estos entornos, el p53 mutante fue m\u00e1s efectivo que el p53 natural para inhibir la formaci\u00f3n de tumores. Mec\u00e1nicamente, los efectos supresores de tumores de p53 mutante fueron impulsados \u200b\u200bpor la interrupci\u00f3n de la v\u00eda WNT, a trav\u00e9s de la prevenci\u00f3n de la uni\u00f3n de TCF4 a la cromatina. En particular, este efecto supresor de tumores fue completamente abolido por el microbioma intestinal. Adem\u00e1s, un solo metabolito derivado de la microbiota intestinal, el \u00e1cido g\u00e1lico, podr\u00eda reproducir todo el efecto del microbioma.<\/p>\n<p>La suplementaci\u00f3n de ratones mutantes p53 esterilizados en el intestino y organoides mutantes en p53 con \u00e1cido g\u00e1lico restableci\u00f3 la interacci\u00f3n TCF4-cromatina y la hiperactivaci\u00f3n de WNT, lo que confiere un fenotipo maligno a los organoides y en todo el intestino.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kadosh, E., Snir-Alkalay, I., Venkatachalam, A. et al.\u00a0The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.\u00a0Nature\u00a0(2020). https:\/\/doi.org\/10.1038\/s41586-020-2541-0 Las mutaciones som\u00e1ticas en p53, que inactivan la funci\u00f3n supresora de tumores de p53 y a menudo confieren propiedades de ganancia de funci\u00f3n oncog\u00e9nicas, son muy comunes en el c\u00e1ncer. Aqu\u00ed estudiamos los efectos de las mutaciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-43287","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;El microbioma intestinal cambia el p53 mutante de supresor tumoral a oncog\u00e9nico&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43287\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;El microbioma intestinal cambia el p53 mutante de supresor tumoral a oncog\u00e9nico&quot; -\" \/>\n<meta property=\"og:description\" content=\"Kadosh, E., Snir-Alkalay, I., Venkatachalam, A. et al.\u00a0The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.\u00a0Nature\u00a0(2020). https:\/\/doi.org\/10.1038\/s41586-020-2541-0 Las mutaciones som\u00e1ticas en p53, que inactivan la funci\u00f3n supresora de tumores de p53 y a menudo confieren propiedades de ganancia de funci\u00f3n oncog\u00e9nicas, son muy comunes en el c\u00e1ncer. 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