{"id":43603,"date":"2020-08-17T00:30:00","date_gmt":"2020-08-16T22:30:00","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43603"},"modified":"2020-08-17T21:35:19","modified_gmt":"2020-08-17T19:35:19","slug":"area-de-conocimiento-naturopatia-descriptiva-epilepsia-en-glioblastoma-multiforme-correlacion-con-los-niveles-de-glutamina-sintetasa","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43603","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abEpilepsia en glioblastoma multiforme: correlaci\u00f3n con los niveles de glutamina sintetasa\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-n5Em93bkK9A\/XzraHsdrfZI\/AAAAAAAAfOs\/lpiwR3VoCqgSpq1oRSJIRtSRIBpDS8uSQCLcBGAsYHQ\/s1600\/Journal_neuro-oncology.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-n5Em93bkK9A\/XzraHsdrfZI\/AAAAAAAAfOs\/lpiwR3VoCqgSpq1oRSJIRtSRIBpDS8uSQCLcBGAsYHQ\/s320\/Journal_neuro-oncology.jpg\" width=\"239\" height=\"320\" border=\"0\" data-original-width=\"827\" data-original-height=\"1104\" \/><\/a>Rosati, A., Marconi, S., Pollo, B., Tomassini, A., Lovato, L., Maderna, E., &#8230; &amp; Bonetti, B. (2009).\u00a0<a href=\"https:\/\/d1wqtxts1xzle7.cloudfront.net\/48024192\/s11060-008-9794-z20160813-14386-1ajpxyk.pdf?1471103003=&amp;response-content-disposition=inline%3B+filename%3DEpilepsy_in_glioblastoma_multiforme_corr.pdf&amp;Expires=1597621119&amp;Signature=JetOaQuQ7cAut9yLt7q4ZFIQCl4M3OIBaAshOkF2fv8L3Ep~YBVmUjTzNEoE1Pkixse1KC2VzdK-hPpo~JhT3Nugj4jgxh4tZAcg6Bgqf5hmxCuJW0ybRmJZ5pzy2~oBrvwwHU-oDaSNPFYhmB0WXkIG9fiLDw~JnUsZWnre~QyS7HT7ecYSEwmyDRnJEhNvu~FZ20sMfLCLJRgzpMInctPbPr~Wc2suBre2Jtfqb47zgLR3yq6NNQDK5vDTWK1xIskhjPgJpV25ywwcir3FXhWDXfqo0FFT2JT1PU93A3PW~2cYfoW5Uig9agEhTADx34jQeatt7TK~LYcz6jySbw__&amp;Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA\">Epilepsy in glioblastoma multiforme: correlation with glutamine synthetase levels<\/a>.\u00a0<i>Journal of neuro-oncology<\/i>, 93(3), 319-324.<\/p>\n<p>PROP\u00d3SITO: La hip\u00f3tesis abordada por este estudio es que una deficiencia de glutamina sintetasa (GS) en astrocitos neopl\u00e1sicos es una posible base molecular asociada con la generaci\u00f3n de convulsiones en el glioblastoma multiforme (GBM).<\/p>\n<p>M\u00c9TODOS: Se realiz\u00f3 un an\u00e1lisis de transferencia Western cuantitativo de GS en 20 individuos operados de glioma maligno.<\/p>\n<p>RESULTADOS: Los niveles de GS en pacientes con GBM y epilepsia fueron significativamente m\u00e1s bajos (rango 0,04-1,15; media 0,35 +\/- 0,36; mediana 0,25) que en individuos con GBM no epil\u00e9pticos (rango 0,78-3,97; media 1,64 +\/- 0,99 ; mediana 1,25; P = 0,002). No se ha encontrado relaci\u00f3n entre las caracter\u00edsticas histol\u00f3gicas (es decir, necrosis, gliosis, estroma, c\u00e9lulas inflamatorias, c\u00e9lulas gigantes y hemosiderina) y expresi\u00f3n de GS o epilepsia.<\/p>\n<p>DISCUSI\u00d3N: Aunque la epileptog\u00e9nesis en el glioma es multifactorial, es concebible que una regulaci\u00f3n a la baja de GS pueda tener un papel proepileptog\u00e9nico importante en GBM, a trav\u00e9s de la desaceleraci\u00f3n del ciclo glutamato-glutamina. Este estudio sugiere que las convulsiones en GBM se combinan con una deficiencia enzim\u00e1tica altamente localizada. La manipulaci\u00f3n de la actividad de GS podr\u00eda constituir un principio novedoso para inhibir las convulsiones en pacientes con epilepsia por glioma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rosati, A., Marconi, S., Pollo, B., Tomassini, A., Lovato, L., Maderna, E., &#8230; &amp; Bonetti, B. (2009).\u00a0Epilepsy in glioblastoma multiforme: correlation with glutamine synthetase levels.\u00a0Journal of neuro-oncology, 93(3), 319-324. PROP\u00d3SITO: La hip\u00f3tesis abordada por este estudio es que una deficiencia de glutamina sintetasa (GS) en astrocitos neopl\u00e1sicos es una posible base molecular asociada con la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-43603","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Epilepsia en glioblastoma multiforme: correlaci\u00f3n con los niveles de glutamina sintetasa&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43603\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Epilepsia en glioblastoma multiforme: correlaci\u00f3n con los niveles de glutamina sintetasa&quot; -\" \/>\n<meta property=\"og:description\" content=\"Rosati, A., Marconi, S., Pollo, B., Tomassini, A., Lovato, L., Maderna, E., &#8230; &amp; Bonetti, B. 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PROP\u00d3SITO: La hip\u00f3tesis abordada por este estudio es que una deficiencia de glutamina sintetasa (GS) en astrocitos neopl\u00e1sicos es una posible base molecular asociada con la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43603\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-16T22:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-17T19:35:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-n5Em93bkK9A\/XzraHsdrfZI\/AAAAAAAAfOs\/lpiwR3VoCqgSpq1oRSJIRtSRIBpDS8uSQCLcBGAsYHQ\/s320\/Journal_neuro-oncology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" 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