{"id":43615,"date":"2020-08-17T04:30:52","date_gmt":"2020-08-17T02:30:52","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43615"},"modified":"2020-08-17T22:20:08","modified_gmt":"2020-08-17T20:20:08","slug":"43615","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43615","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl flavonoide kaempferol sensibiliza las c\u00e9lulas de glioma humano a la apoptosis mediada por TRAIL mediante la degradaci\u00f3n proteas\u00f3mica de la survivina\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-XH3_EqrfPZs\/XzrmHm8vSdI\/AAAAAAAAfPU\/xqBYnU9JnKo_52vFIY5kp3mW0_KkxrHwACLcBGAsYHQ\/s1600\/Molecular_Cancer%2BTherapeutics.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-XH3_EqrfPZs\/XzrmHm8vSdI\/AAAAAAAAfPU\/xqBYnU9JnKo_52vFIY5kp3mW0_KkxrHwACLcBGAsYHQ\/s1600\/Molecular_Cancer%2BTherapeutics.jpg\" border=\"0\" data-original-width=\"195\" data-original-height=\"259\" \/><\/a>Siegelin, M. D., Reuss, D. E., Habel, A., Herold-Mende, C., &amp; von Deimling, A. (2008).\u00a0<a href=\"https:\/\/mct.aacrjournals.org\/content\/molcanther\/7\/11\/3566.full.pdf\">The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin<\/a>.\u00a0<i>Molecular cancer therapeutics<\/i>, 7(11), 3566-3574.<\/p>\n<p>La resistencia al ligando inductor de apoptosis relacionado con el factor de necrosis tumoral (TRAIL \/ Apo2L) limita su potencial como f\u00e1rmaco para la terapia del c\u00e1ncer.<\/p>\n<p>Aqu\u00ed, informamos que el kaempferol, un flavonoide vegetal bioactivo, sensibiliza las c\u00e9lulas de glioma U251 y U87 a la apoptosis mediada por TRAIL. Por el contrario, las c\u00e9lulas U373 no se ven afectadas por el tratamiento con kaempferol. El tratamiento de kaempferol solo durante 24 h no indujo apoptosis en las l\u00edneas celulares.<\/p>\n<p>Proporcionamos evidencia de que la apoptosis inducida por TRAIL est\u00e1 parcialmente impulsada por la reducci\u00f3n de los niveles de prote\u00edna survivina mediada por kaempferol. En el tratamiento con kaempferol, se observ\u00f3 una degradaci\u00f3n proteas\u00f3mica de la survivina. La inhibici\u00f3n de la degradaci\u00f3n proteasomal con MG132 en c\u00e9lulas tratadas con kaempferol restaur\u00f3 los niveles de prote\u00edna survivina en ambas l\u00edneas de c\u00e9lulas gliales.<\/p>\n<p>En consecuencia, la sobreexpresi\u00f3n de survivin atenu\u00f3 la apoptosis inducida por TRAIL-kaempferol. Adicionalmente, mostramos que el kaempferol media la regulaci\u00f3n por disminuci\u00f3n de Akt fosforilada, lo que reduce a\u00fan m\u00e1s el nivel de prote\u00edna survivina. Adem\u00e1s, el bloqueo de la actividad Akt de la serina \/ treonina quinasa por el kaempferol es importante para la inhibici\u00f3n de la survivina porque la Akt fosforilada activa mejora la estabilidad de la survivina. Sin embargo, tambi\u00e9n mostramos que el tratamiento combinado de TRAIL y kaempferol induce la escisi\u00f3n (activaci\u00f3n) de la caspasa-8, ejerciendo as\u00ed un efecto proapopt\u00f3tico independiente de la survivina que se sabe que no inhibe la activaci\u00f3n de la caspasa-8.<\/p>\n<p>Otros efectos inducidos por el kaempferol fueron la supresi\u00f3n del inhibidor ligado al cromosoma X de las prote\u00ednas de la apoptosis como miembros antiapopt\u00f3ticos de la familia Bcl-2, Bcl-2, Bcl-xL y Mcl-1 de una manera dependiente de la concentraci\u00f3n.<\/p>\n<p>En resumen, demostramos que la supresi\u00f3n de la survivina es un mecanismo esencial en la apoptosis mediada por TRAIL-kaempferol.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Siegelin, M. D., Reuss, D. E., Habel, A., Herold-Mende, C., &amp; von Deimling, A. (2008).\u00a0The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin.\u00a0Molecular cancer therapeutics, 7(11), 3566-3574. La resistencia al ligando inductor de apoptosis relacionado con el factor de necrosis tumoral (TRAIL \/ Apo2L) limita su potencial como f\u00e1rmaco [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-43615","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El flavonoide kaempferol sensibiliza las c\u00e9lulas de glioma humano a la apoptosis mediada por TRAIL mediante la degradaci\u00f3n proteas\u00f3mica de la survivina&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43615\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El flavonoide kaempferol sensibiliza las c\u00e9lulas de glioma humano a la apoptosis mediada por TRAIL mediante la degradaci\u00f3n proteas\u00f3mica de la survivina&quot; -\" \/>\n<meta property=\"og:description\" content=\"Siegelin, M. D., Reuss, D. E., Habel, A., Herold-Mende, C., &amp; von Deimling, A. (2008).\u00a0The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin.\u00a0Molecular cancer therapeutics, 7(11), 3566-3574. 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