{"id":43686,"date":"2020-08-20T07:30:25","date_gmt":"2020-08-20T05:30:25","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43686"},"modified":"2020-08-20T17:52:04","modified_gmt":"2020-08-20T15:52:04","slug":"43686","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43686","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa ADN polimerasa zeta y el control de la mutag\u00e9nesis inducida por el da\u00f1o del ADN en eucariotas\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-sXX-X7m0hPI\/Xz6bpAw-D2I\/AAAAAAAAfTU\/5pRsVKOpqEoT17yMuPgSlTBfbyZxqTJQgCLcBGAsYHQ\/s1600\/Cancer_surveys.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-sXX-X7m0hPI\/Xz6bpAw-D2I\/AAAAAAAAfTU\/5pRsVKOpqEoT17yMuPgSlTBfbyZxqTJQgCLcBGAsYHQ\/s1600\/Cancer_surveys.png\" border=\"0\" data-original-width=\"200\" data-original-height=\"200\" \/><\/a>Lawrence, C. W., &amp; Hinkle, D. C. (1996).\u00a0<a href=\"https:\/\/europepmc.org\/article\/med\/8977026\">DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes<\/a>.\u00a0<i>Cancer surveys<\/i>, 28, 21-31.<\/p>\n<p>Es probable que las mutaciones inducidas por el da\u00f1o del ADN que surgen durante el curso de la replicaci\u00f3n de la translesi\u00f3n sean una causa importante que contribuya al desarrollo de muchos c\u00e1nceres.<\/p>\n<p>En la levadura en ciernes, Saccharomyces cerevisiae, un buen sistema modelo con el que investigar este proceso, la mutag\u00e9nesis est\u00e1 asociada con la v\u00eda de reparaci\u00f3n de RAD6 y depende de las funciones de los genes REV1, REV3 y REV7. Las prote\u00ednas Rev3 y Rev7 son subunidades de un nuevo tipo de ADN polimerasa, llamada ADN polimerasa zeta, que parece llevar a cabo la replicaci\u00f3n de translesi\u00f3n, pero ninguna otra funci\u00f3n de reparaci\u00f3n, recombinaci\u00f3n o replicaci\u00f3n.<\/p>\n<p>Pol zeta se replica m\u00e1s all\u00e1 de un d\u00edmero de ciclobutano TT con una mayor eficacia que la pol alfa de levadura, es menos propenso que esta enzima a insertar un nucle\u00f3tido incorrecto y es m\u00e1s eficaz para alargar desde un extremo no emparejado. La prote\u00edna Rev1 es una nucleotidil transferasa terminal que inserta dCMP frente a la plantilla G, A y sitios ab\u00e1sicos.<\/p>\n<p>Los tipos de mutaciones inducidas durante la replicaci\u00f3n de la translesi\u00f3n parecen depender en gran medida de la estructura de la lesi\u00f3n, pero la frecuencia y precisi\u00f3n de la derivaci\u00f3n tambi\u00e9n dependen de las condiciones de replicaci\u00f3n.<\/p>\n<p>La inhibici\u00f3n de la actividad o expresi\u00f3n de pol zeta puede ser cl\u00ednicamente \u00fatil para pacientes que se someten a terapia contra el c\u00e1ncer o para aquellos con una predisposici\u00f3n familiar al c\u00e1ncer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lawrence, C. W., &amp; Hinkle, D. C. (1996).\u00a0DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes.\u00a0Cancer surveys, 28, 21-31. Es probable que las mutaciones inducidas por el da\u00f1o del ADN que surgen durante el curso de la replicaci\u00f3n de la translesi\u00f3n sean una causa importante que contribuya al desarrollo de muchos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-43686","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La ADN polimerasa zeta y el control de la mutag\u00e9nesis inducida por el da\u00f1o del ADN en eucariotas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43686\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La ADN polimerasa zeta y el control de la mutag\u00e9nesis inducida por el da\u00f1o del ADN en eucariotas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Lawrence, C. 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