{"id":43689,"date":"2020-08-21T00:30:36","date_gmt":"2020-08-20T22:30:36","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43689"},"modified":"2020-08-22T14:49:23","modified_gmt":"2020-08-22T12:49:23","slug":"43689","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43689","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abRegulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-COU79agaxhQ\/X0ET2Tj4LbI\/AAAAAAAAfUo\/iO5W758D_8IMGKtqg-3s2AJuJtoB631CgCLcBGAsYHQ\/s1600\/Biochemical_biophysical%2Bresearch%2Bcommunications2.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-COU79agaxhQ\/X0ET2Tj4LbI\/AAAAAAAAfUo\/iO5W758D_8IMGKtqg-3s2AJuJtoB631CgCLcBGAsYHQ\/s320\/Biochemical_biophysical%2Bresearch%2Bcommunications2.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Terashima, M., Ishimura, A., Wanna-udom, S., &amp; Suzuki, T. (2017).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006291X17313906\">Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells<\/a>.\u00a0<i>Biochemical and Biophysical Research Communications<\/i>, 490(4), 1407-1413.<\/p>\n<p>La metilaci\u00f3n de histonas est\u00e1 asociada con varios procesos biol\u00f3gicos y patol\u00f3gicos, incluido el desarrollo del c\u00e1ncer. KDM6A es un gen supresor de tumores candidato que codifica una histona H3 lisina 27 (H3K27) demetilasa .<\/p>\n<p>En este estudio, descubrimos que la expresi\u00f3n ect\u00f3pica de KDM6A antagoniz\u00f3 la transici\u00f3n epitelial-mesenquimal (EMT) inducida por TGF-\u03b2 y la migraci\u00f3n celular de las l\u00edneas celulares de c\u00e1ncer de pulm\u00f3n a trav\u00e9s de su actividad desmetilasa. KDM6A contrarrest\u00f3 los cambios dependientes de TGF-\u03b2 en la expresi\u00f3n de genes relacionados con la EMT como CDH1 \/ E-cadherina , FN1 \/ Fibronectina , familia ZEB y microARN-200familia.<\/p>\n<p>Las investigaciones mecanicistas revelaron que KDM6A inhibi\u00f3 el reclutamiento de la metiltransferasa H3K27 de la histona EZH2 y la metilaci\u00f3n de H3K27 en las regiones reguladoras de los genes diana, como la familia CDH1 y microARN-200 . La ca\u00edda de KDM6A no procedi\u00f3 a la EMT por s\u00ed misma, pero influy\u00f3 en la expresi\u00f3n de genes diana espec\u00edficos cr\u00edticos para la EMT, lo que sugiere que el KDM6A end\u00f3geno estaba involucrado en el programa transcripcional inductor de EMT.<\/p>\n<p>Este estudio demostr\u00f3 un nuevo papel regulador de la histona desmetilasa KDM6A en el control epigen\u00e9tico del proceso EMT en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Terashima, M., Ishimura, A., Wanna-udom, S., &amp; Suzuki, T. (2017).\u00a0Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.\u00a0Biochemical and Biophysical Research Communications, 490(4), 1407-1413. La metilaci\u00f3n de histonas est\u00e1 asociada con varios procesos biol\u00f3gicos y patol\u00f3gicos, incluido el desarrollo del c\u00e1ncer. KDM6A es un gen supresor de tumores candidato que codifica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-43689","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Regulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43689\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Regulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n&quot; -\" \/>\n<meta property=\"og:description\" content=\"Terashima, M., Ishimura, A., Wanna-udom, S., &amp; Suzuki, T. (2017).\u00a0Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.\u00a0Biochemical and Biophysical Research Communications, 490(4), 1407-1413. La metilaci\u00f3n de histonas est\u00e1 asociada con varios procesos biol\u00f3gicos y patol\u00f3gicos, incluido el desarrollo del c\u00e1ncer. KDM6A es un gen supresor de tumores candidato que codifica [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43689\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-20T22:30:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-22T12:49:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-COU79agaxhQ\/X0ET2Tj4LbI\/AAAAAAAAfUo\/iO5W758D_8IMGKtqg-3s2AJuJtoB631CgCLcBGAsYHQ\/s320\/Biochemical_biophysical%2Bresearch%2Bcommunications2.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43689#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43689\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abRegulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\u00bb\",\"datePublished\":\"2020-08-20T22:30:36+00:00\",\"dateModified\":\"2020-08-22T12:49:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43689\"},\"wordCount\":289,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Naturopat\u00eda Descriptiva\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=43689#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43689\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43689\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \\\"Regulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-08-20T22:30:36+00:00\",\"dateModified\":\"2020-08-22T12:49:23+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43689#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=43689\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43689#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abRegulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \"Regulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=43689","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \"Regulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\" -","og_description":"Terashima, M., Ishimura, A., Wanna-udom, S., &amp; Suzuki, T. (2017).\u00a0Epigenetic regulation of epithelial-mesenchymal transition by KDM6A histone demethylase in lung cancer cells.\u00a0Biochemical and Biophysical Research Communications, 490(4), 1407-1413. La metilaci\u00f3n de histonas est\u00e1 asociada con varios procesos biol\u00f3gicos y patol\u00f3gicos, incluido el desarrollo del c\u00e1ncer. KDM6A es un gen supresor de tumores candidato que codifica [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=43689","article_published_time":"2020-08-20T22:30:36+00:00","article_modified_time":"2020-08-22T12:49:23+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-COU79agaxhQ\/X0ET2Tj4LbI\/AAAAAAAAfUo\/iO5W758D_8IMGKtqg-3s2AJuJtoB631CgCLcBGAsYHQ\/s320\/Biochemical_biophysical%2Bresearch%2Bcommunications2.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43689#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43689"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abRegulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\u00bb","datePublished":"2020-08-20T22:30:36+00:00","dateModified":"2020-08-22T12:49:23+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43689"},"wordCount":289,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Naturopat\u00eda Descriptiva"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=43689#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43689","url":"https:\/\/rina.naturopatiadigital.eu\/?p=43689","name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \"Regulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-08-20T22:30:36+00:00","dateModified":"2020-08-22T12:49:23+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43689#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=43689"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43689#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abRegulaci\u00f3n epigen\u00e9tica de la transici\u00f3n epitelio-mesenquimatosa por la histona desmetilasa KDM6A en c\u00e9lulas de c\u00e1ncer de pulm\u00f3n\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/43689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43689"}],"version-history":[{"count":2,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/43689\/revisions"}],"predecessor-version":[{"id":43691,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/43689\/revisions\/43691"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}