{"id":43692,"date":"2020-08-21T01:30:45","date_gmt":"2020-08-20T23:30:45","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43692"},"modified":"2020-08-22T15:14:28","modified_gmt":"2020-08-22T13:14:28","slug":"area-de-conocimiento-naturopatia-descriptiva-funciones-emergentes-de-las-histonas-desacetilasas-en-la-atrofia-muscular-relacionada-con-la-edad","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43692","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abFunciones emergentes de las histonas desacetilasas en la atrofia muscular relacionada con la edad\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-6tdwTRXW03U\/X0EZoLJauQI\/AAAAAAAAfUw\/cX2SR4E7cd4ZHp6mGOoxTEqrjvuTFfwCQCLcBGAsYHQ\/s1600\/Nutrition_healthy%2Baging.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-6tdwTRXW03U\/X0EZoLJauQI\/AAAAAAAAfUw\/cX2SR4E7cd4ZHp6mGOoxTEqrjvuTFfwCQCLcBGAsYHQ\/s1600\/Nutrition_healthy%2Baging.jpg\" border=\"0\" data-original-width=\"148\" data-original-height=\"203\" \/><\/a>Walsh, M. E., &amp; Van Remmen, H. (2016).\u00a0<a href=\"https:\/\/content.iospress.com\/articles\/nutrition-and-healthy-aging\/nha160005\">Emerging roles for histone deacetylases in age-related muscle atrophy<\/a>.\u00a0<i>Nutrition and healthy aging<\/i>, 4(1), 17-30.<\/p>\n<p>ANTECEDENTES: La atrofia del m\u00fasculo esquel\u00e9tico durante el envejecimiento, un proceso conocido como sarcopenia, se asocia con debilidad muscular, fragilidad y p\u00e9rdida de independencia en los adultos mayores. Los mecanismos que contribuyen a la sarcopenia no se comprenden totalmente, pero se ha observado una p\u00e9rdida de fibra muscular debido a la apoptosis, la reducci\u00f3n de la estimulaci\u00f3n de las v\u00edas anab\u00f3licas, la activaci\u00f3n de las v\u00edas catab\u00f3licas, la denervaci\u00f3n y el metabolismo alterado en el m\u00fasculo de viejos roedores y humanos.<\/p>\n<p>OBJETIVO: Recientemente, las histonas desacetilasas (HDAC) se han implicado en la atrofia muscular y la disfunci\u00f3n debido a la denervaci\u00f3n, distrofia muscular y desuso, y las HDAC juegan un papel clave en la regulaci\u00f3n del metabolismo en el m\u00fasculo esquel\u00e9tico. En esta revisi\u00f3n, discutiremos el papel de los HDAC en la atrofia muscular y el potencial de los inhibidores de HDAC para el tratamiento de la sarcopenia.<\/p>\n<p>CONCLUSIONES: Varias isoformas de HDAC son objetivos potenciales para la intervenci\u00f3n en la sarcopenia. La inhibici\u00f3n de HDAC1 previene la atrofia muscular debido a la privaci\u00f3n de nutrientes. HDAC3 regula el metabolismo en el m\u00fasculo esquel\u00e9tico y puede inhibir el metabolismo oxidativo durante el envejecimiento. HDAC4 y HDAC5 se han implicado en la atrofia muscular debido a la denervaci\u00f3n, un proceso implicado en la sarcopenia. Los inhibidores de HDAC ya est\u00e1n en uso en la cl\u00ednica, y existe la promesa de apuntar a los HDAC para el tratamiento de la sarcopenia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Walsh, M. E., &amp; Van Remmen, H. (2016).\u00a0Emerging roles for histone deacetylases in age-related muscle atrophy.\u00a0Nutrition and healthy aging, 4(1), 17-30. ANTECEDENTES: La atrofia del m\u00fasculo esquel\u00e9tico durante el envejecimiento, un proceso conocido como sarcopenia, se asocia con debilidad muscular, fragilidad y p\u00e9rdida de independencia en los adultos mayores. Los mecanismos que contribuyen a la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-43692","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Funciones emergentes de las histonas desacetilasas en la atrofia muscular relacionada con la edad&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43692\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;Funciones emergentes de las histonas desacetilasas en la atrofia muscular relacionada con la edad&quot; -\" \/>\n<meta property=\"og:description\" content=\"Walsh, M. E., &amp; Van Remmen, H. (2016).\u00a0Emerging roles for histone deacetylases in age-related muscle atrophy.\u00a0Nutrition and healthy aging, 4(1), 17-30. ANTECEDENTES: La atrofia del m\u00fasculo esquel\u00e9tico durante el envejecimiento, un proceso conocido como sarcopenia, se asocia con debilidad muscular, fragilidad y p\u00e9rdida de independencia en los adultos mayores. Los mecanismos que contribuyen a la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43692\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-20T23:30:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-22T13:14:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-6tdwTRXW03U\/X0EZoLJauQI\/AAAAAAAAfUw\/cX2SR4E7cd4ZHp6mGOoxTEqrjvuTFfwCQCLcBGAsYHQ\/s1600\/Nutrition_healthy%2Baging.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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