{"id":43694,"date":"2020-08-21T02:30:37","date_gmt":"2020-08-21T00:30:37","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43694"},"modified":"2020-08-22T15:36:22","modified_gmt":"2020-08-22T13:36:22","slug":"area-de-conocimiento-tecnologia-naturopatica-o-naturopatia-aplicada-modulo-naturopatia-alimentaria-trofologia-los-extractos-fenolicos-brutos-del-aceite-de-oliva-virgen-extra-evitan-la-resisten","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43694","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLos extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-U0c1qZ7Z46c\/X0Ee4KZdwyI\/AAAAAAAAfU8\/8ODyKU3IsK8VBbkVm3JB8_wWw0d8gEk_ACLcBGAsYHQ\/s1600\/International_Journal%2Bof%2BOncology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-U0c1qZ7Z46c\/X0Ee4KZdwyI\/AAAAAAAAfU8\/8ODyKU3IsK8VBbkVm3JB8_wWw0d8gEk_ACLcBGAsYHQ\/s1600\/International_Journal%2Bof%2BOncology.jpg\" border=\"0\" data-original-width=\"151\" data-original-height=\"209\" \/><\/a>Oliveras-Ferraros, C., Fernandez-Arroyo, S., Vazquez-Martin, A., Lozano-S\u00e1nchez, J., Cuf\u00ed, S., Joven, J., &#8230; &amp; Menendez, J. A. (2011).\u00a0<a href=\"https:\/\/scholar.google.com\/scholar_url?url=https:\/\/www.spandidos-publications.com\/ijo\/38\/6\/1533\/download&amp;hl=es&amp;sa=T&amp;oi=gsb-gga&amp;ct=res&amp;cd=0&amp;d=12967898567794921376&amp;ei=ev6XXMGICo7jmQGb3aLAAQ&amp;scisig=AAGBfm2uXu0AIOMi_rz__-Fs6oEAtB4-iQ\">Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1\/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2\/M arrest and hyperacetylation of Histone H3<\/a>.\u00a0<i>International journal of oncology<\/i>, 38(6), 1533-1547.<\/p>\n<p>Caracterizaci\u00f3n de la funci\u00f3n molecular de los fenoles complejos presentes naturalmente en el aceite de oliva virgen extra (EVOO) contra la l\u00ednea celular JIMT-1 amplificada con el gen HER2, un modelo \u00fanico de c\u00e1ncer de mama que exhibe inherentemente resistencia cruzada a m\u00faltiples medicamentos dirigidos contra HER1 \/ 2, incluidos el trastuzumab, el gefitinib, el erlotinib y el lapatinib pueden subrayar las mol\u00e9culas de c\u00e1ncer innovadoras con nuevas dianas terap\u00e9uticas, ya que deben evitar eficazmente la resistencia de novo a los inhibidores de HER1 \/ 2 para provocar efectos tumoricidas.<\/p>\n<p>Identificamos las v\u00edas de se\u00f1alizaci\u00f3n pivotal asociadas con la eficacia de los extractos fen\u00f3licos crudos (PE) obtenidos de 14 monovarietales de los AOVE espa\u00f1oles. i) La viabilidad celular basada en el MTT y la HPLC acopladas a los ensayos de espectrometr\u00eda de masas de tiempo de vuelo (TOF) revelaron que la actividad anticancer\u00edgena de los PE de AOVE se correlacion\u00f3 positivamente con el \u00edndice fen\u00f3lico (es decir, el contenido total de fen\u00f3licos) y con una mayor presencia del complejo polifenoles secoiridoides en lugar de lignanos. ii) Los an\u00e1lisis de todo el genoma utilizando arrays humanos de 44 K Agilent seguidos de la investigaci\u00f3n basada en el an\u00e1lisis de enriquecimiento de conjuntos de genes (GSEA) de la base de datos de la ruta Kyoto Encyclopedia of Genes and Genomes (KEGG) revelaron una modulaci\u00f3n diferencial del transcriptoma JIMT-1 en el nivel del ciclo celular y v\u00edas de p53.<\/p>\n<p>Los PE de AOVE tuvieron un impacto diferencial en el estado de expresi\u00f3n de los genes GADD45 relacionados con el punto de control G2-M sensibles al estr\u00e9s y de los genes CDKN1A, CDKN1C y PMAIP-1 relacionados con p53. iii) El ciclo celular y los an\u00e1lisis de microscop\u00eda de fluorescencia confirmaron que el AOVE PE rico en secoiridoide inhibe la mitosis para promover la detenci\u00f3n del ciclo celular G2-M. Esto se acompa\u00f1\u00f3 con la aparici\u00f3n de una tinci\u00f3n difusa y uniforme del ADN con \u03b3H2AX y una hiperacetilaci\u00f3n pan-nuclear de histona H3 en la lisina 18. iv) Nodo de se\u00f1alizaci\u00f3n semicuantitativo los ELISA de m\u00faltiples objetivos determinaron que el AEEP rico en secoiridoide activ\u00f3 dr\u00e1sticamente el mit\u00f3geno activado prote\u00edna quinasas MEK1 y p38 MAPK, una quinasa relacionada con GADD45 implicada en la acetilaci\u00f3n de histona H3.<\/p>\n<p>Secoiridoides, una familia de polifenoles complejos caracter\u00edsticos de las plantas Oleaceae, parecen permitir que las histonas permanezcan en estados hiperacetilados y, a trav\u00e9s de las alteraciones resultantes en la regulaci\u00f3n de los genes, reduzcan la viabilidad mit\u00f3tica y la competencia metab\u00f3lica de las c\u00e9lulas de c\u00e1ncer de mama inherentemente refractarias a las terapias dirigidas a HER ab initio. Oleaceae secoiridoides podr\u00eda proporcionar una valiosa plataforma fitoqu\u00edmica para el dise\u00f1o de mol\u00e9culas de c\u00e1ncer de mama de tipo antif\u00e1rmaco fitofarmac\u00e9uticos de segunda generaci\u00f3n m\u00e1s farmacol\u00f3gicamente activas con un modo de acci\u00f3n \u00fanico.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oliveras-Ferraros, C., Fernandez-Arroyo, S., Vazquez-Martin, A., Lozano-S\u00e1nchez, J., Cuf\u00ed, S., Joven, J., &#8230; &amp; Menendez, J. A. (2011).\u00a0Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1\/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2\/M arrest and hyperacetylation of Histone H3.\u00a0International journal of oncology, 38(6), 1533-1547. Caracterizaci\u00f3n de la funci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-43694","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;Los extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43694\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;Los extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3&quot; -\" \/>\n<meta property=\"og:description\" content=\"Oliveras-Ferraros, C., Fernandez-Arroyo, S., Vazquez-Martin, A., Lozano-S\u00e1nchez, J., Cuf\u00ed, S., Joven, J., &#8230; &amp; Menendez, J. A. (2011).\u00a0Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1\/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2\/M arrest and hyperacetylation of Histone H3.\u00a0International journal of oncology, 38(6), 1533-1547. Caracterizaci\u00f3n de la funci\u00f3n [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43694\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-21T00:30:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-22T13:36:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-U0c1qZ7Z46c\/X0Ee4KZdwyI\/AAAAAAAAfU8\/8ODyKU3IsK8VBbkVm3JB8_wWw0d8gEk_ACLcBGAsYHQ\/s1600\/International_Journal%2Bof%2BOncology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43694#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43694\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLos extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\u00bb\",\"datePublished\":\"2020-08-21T00:30:37+00:00\",\"dateModified\":\"2020-08-22T13:36:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43694\"},\"wordCount\":640,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Naturopat\u00eda Alimentaria TROFOLOGIA\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=43694#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43694\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43694\",\"name\":\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: \\\"Los extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-08-21T00:30:37+00:00\",\"dateModified\":\"2020-08-22T13:36:22+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43694#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=43694\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=43694#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLos extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: \"Los extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=43694","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: \"Los extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\" -","og_description":"Oliveras-Ferraros, C., Fernandez-Arroyo, S., Vazquez-Martin, A., Lozano-S\u00e1nchez, J., Cuf\u00ed, S., Joven, J., &#8230; &amp; Menendez, J. A. (2011).\u00a0Crude phenolic extracts from extra virgin olive oil circumvent de novo breast cancer resistance to HER1\/HER2-targeting drugs by inducing GADD45-sensed cellular stress, G2\/M arrest and hyperacetylation of Histone H3.\u00a0International journal of oncology, 38(6), 1533-1547. Caracterizaci\u00f3n de la funci\u00f3n [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=43694","article_published_time":"2020-08-21T00:30:37+00:00","article_modified_time":"2020-08-22T13:36:22+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-U0c1qZ7Z46c\/X0Ee4KZdwyI\/AAAAAAAAfU8\/8ODyKU3IsK8VBbkVm3JB8_wWw0d8gEk_ACLcBGAsYHQ\/s1600\/International_Journal%2Bof%2BOncology.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43694#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43694"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLos extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\u00bb","datePublished":"2020-08-21T00:30:37+00:00","dateModified":"2020-08-22T13:36:22+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43694"},"wordCount":640,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Naturopat\u00eda Alimentaria TROFOLOGIA"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=43694#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43694","url":"https:\/\/rina.naturopatiadigital.eu\/?p=43694","name":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: \"Los extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-08-21T00:30:37+00:00","dateModified":"2020-08-22T13:36:22+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43694#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=43694"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=43694#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLos extractos fen\u00f3licos brutos del aceite de oliva virgen extra evitan la resistencia de novo del c\u00e1ncer de mama a los f\u00e1rmacos dirigidos a HER1 \/ HER2 al inducir el estr\u00e9s celular detectado por GADD45, la detenci\u00f3n de G2 \/ M y la hiperacetilaci\u00f3n de la histona H3\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/43694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=43694"}],"version-history":[{"count":1,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/43694\/revisions"}],"predecessor-version":[{"id":43695,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/43694\/revisions\/43695"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=43694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=43694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=43694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}