{"id":43707,"date":"2020-08-22T01:30:54","date_gmt":"2020-08-21T23:30:54","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43707"},"modified":"2020-08-22T16:40:33","modified_gmt":"2020-08-22T14:40:33","slug":"43707","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43707","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPolifenoles como mim\u00e9ticos de restricci\u00f3n cal\u00f3rica e inductores de autofagia en la investigaci\u00f3n sobre el envejecimiento\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-kIqdPAv0HRg\/X0EtC2LEqqI\/AAAAAAAAfVw\/Df8ApgjF_9IqUMKh_Szqba4PKlqespoHwCLcBGAsYHQ\/s1600\/Nutrients3.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-kIqdPAv0HRg\/X0EtC2LEqqI\/AAAAAAAAfVw\/Df8ApgjF_9IqUMKh_Szqba4PKlqespoHwCLcBGAsYHQ\/s320\/Nutrients3.png\" width=\"225\" height=\"320\" border=\"0\" data-original-width=\"1127\" data-original-height=\"1600\" \/><\/a>Yessenkyzy, A., Saliev, T., Zhanaliyeva, M., Masoud, A. R., Umbayev, B., Sergazy, S., &#8230; &amp; Nurgozhin, T. (2020).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7285205\/\">Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research.<\/a>\u00a0<i>Nutrients<\/i>, 12(5), 1344.<\/p>\n<p>Se ha pensado que la restricci\u00f3n cal\u00f3rica favorece la longevidad y el envejecimiento saludable donde la autofagia juega un papel vital. Sin embargo, la autofagia disminuye durante el envejecimiento y eso puede conducir al desarrollo de enfermedades asociadas al envejecimiento como c\u00e1ncer, diabetes, neurodegeneraci\u00f3n, etc. Se demostr\u00f3 que la autofagia puede ser inducida por estr\u00e9s mec\u00e1nico o qu\u00edmico.<\/p>\n<p>En este sentido, se propusieron diversos compuestos farmacol\u00f3gicos, incluidos los polifenoles naturales. Adem\u00e1s de la capacidad de inducir autofagia, los polifenoles, como el resveratrol, son capaces de modular la expresi\u00f3n de factores pro y antiapopt\u00f3ticos, neutralizar especies de radicales libres, afectar las funciones mitocondriales, quelar iones de metales de transici\u00f3n con actividad redox y prevenir la agregaci\u00f3n de prote\u00ednas. . Adem\u00e1s, los polifenoles tienen ventajas en comparaci\u00f3n con los inductores qu\u00edmicos de la autofagia debido a su biocompatibilidad natural intr\u00ednseca y su seguridad.<\/p>\n<p>En este contexto, los polifenoles pueden considerarse como una herramienta terap\u00e9utica potencial para un envejecimiento saludable, ya sea como parte de una dieta o como compuestos separados (suplementos).<\/p>\n<p>Esta revisi\u00f3n analiza el aspecto epigen\u00e9tico y el mecanismo molecular subyacente de los polifenoles como remedio contra el envejecimiento. Adem\u00e1s, tambi\u00e9n se han destacado los avances recientes de estudios sobre la regulaci\u00f3n de la autofagia sirtuina-1 desacetilasa dependiente de NAD (SIRT1), el papel del fenotipo secretor asociado a la senescencia (SASP) en la senescencia de las c\u00e9lulas y su regulaci\u00f3n por polifenoles.<\/p>\n<p>Aparte de eso, la revisi\u00f3n tambi\u00e9n revis\u00f3 la informaci\u00f3n m\u00e1s reciente sobre c\u00f3mo los polifenoles pueden ayudar a mejorar la funci\u00f3n mitocondrial y modular la apoptosis (muerte celular programada).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yessenkyzy, A., Saliev, T., Zhanaliyeva, M., Masoud, A. R., Umbayev, B., Sergazy, S., &#8230; &amp; Nurgozhin, T. (2020).\u00a0Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research.\u00a0Nutrients, 12(5), 1344. Se ha pensado que la restricci\u00f3n cal\u00f3rica favorece la longevidad y el envejecimiento saludable donde la autofagia juega un papel vital. Sin embargo, la autofagia disminuye [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-43707","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Polifenoles como mim\u00e9ticos de restricci\u00f3n cal\u00f3rica e inductores de autofagia en la investigaci\u00f3n sobre el envejecimiento&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43707\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Polifenoles como mim\u00e9ticos de restricci\u00f3n cal\u00f3rica e inductores de autofagia en la investigaci\u00f3n sobre el envejecimiento&quot; -\" \/>\n<meta property=\"og:description\" content=\"Yessenkyzy, A., Saliev, T., Zhanaliyeva, M., Masoud, A. R., Umbayev, B., Sergazy, S., &#8230; &amp; Nurgozhin, T. (2020).\u00a0Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research.\u00a0Nutrients, 12(5), 1344. Se ha pensado que la restricci\u00f3n cal\u00f3rica favorece la longevidad y el envejecimiento saludable donde la autofagia juega un papel vital. Sin embargo, la autofagia disminuye [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43707\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-21T23:30:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-08-22T14:40:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-kIqdPAv0HRg\/X0EtC2LEqqI\/AAAAAAAAfVw\/Df8ApgjF_9IqUMKh_Szqba4PKlqespoHwCLcBGAsYHQ\/s320\/Nutrients3.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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