{"id":43716,"date":"2020-08-22T04:30:14","date_gmt":"2020-08-22T02:30:14","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43716"},"modified":"2020-08-23T11:11:41","modified_gmt":"2020-08-23T09:11:41","slug":"43716","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43716","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abEl estr\u00e9s de por vida acelera el envejecimiento epigen\u00e9tico en una cohorte afroamericana urbana: relevancia de la se\u00f1alizaci\u00f3n de glucocorticoides\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-NtfJSU6b9dM\/X0IyZ0nWgNI\/AAAAAAAAfWs\/1L4tZuXfI0sNB76eRVu9GDritCYiDgwUgCLcBGAsYHQ\/s1600\/Genome_Biology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-NtfJSU6b9dM\/X0IyZ0nWgNI\/AAAAAAAAfWs\/1L4tZuXfI0sNB76eRVu9GDritCYiDgwUgCLcBGAsYHQ\/s1600\/Genome_Biology.jpg\" border=\"0\" data-original-width=\"198\" data-original-height=\"280\" \/><\/a>Zannas, A. S., Arloth, J., Carrillo-Roa, T., Iurato, S., R\u00f6h, S., Ressler, K. J., &#8230; &amp; Menke, A. (2015).\u00a0<a href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-015-0828-5\">Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling<\/a>.\u00a0<i>Genome biology<\/i>, 16(1), 1-12.<\/p>\n<p>Examinamos el efecto de los factores estresantes de por vida en un reloj epigen\u00e9tico que predice la edad basado en la metilaci\u00f3n del ADN.<\/p>\n<p>Despu\u00e9s de controlar la composici\u00f3n del tipo de c\u00e9lulas sangu\u00edneas y los par\u00e1metros de estilo de vida, el estr\u00e9s acumulado de por vida, pero no el maltrato infantil o el estr\u00e9s actual solo, predijo un envejecimiento epigen\u00e9tico acelerado en una cohorte urbana afroamericana (n = 392). Este efecto fue impulsado principalmente por factores estresantes de la vida personal, fue m\u00e1s pronunciado con la edad y se atenu\u00f3 en individuos con mayor exposici\u00f3n al abuso infantil.<\/p>\n<p>Con la hip\u00f3tesis de que estos efectos epigen\u00e9ticos podr\u00edan estar mediados por la se\u00f1alizaci\u00f3n de glucocorticoides, encontramos que un gran n\u00famero (n = 85) de sitios CpG del reloj epigen\u00e9tico se encontraban dentro de los elementos de respuesta de glucocorticoides.<\/p>\n<p>Adem\u00e1s, examinamos los efectos funcionales de los glucocorticoides en los CpG del reloj epigen\u00e9tico en una muestra independiente con datos de metilaci\u00f3n del ADN en todo el genoma (n = 124) y expresi\u00f3n g\u00e9nica (n = 297) antes y despu\u00e9s de la exposici\u00f3n al agonista del receptor de glucocorticoides dexametasona. La dexametasona indujo cambios din\u00e1micos en la metilaci\u00f3n en el 31,2% (110\/353) de estos CpG y la transcripci\u00f3n en el 81,7% (139\/170) de los genes vecinos de los CpG del reloj epigen\u00e9tico.<\/p>\n<p>El an\u00e1lisis de enriquecimiento de la enfermedad de estos genes regulados por dexametasona mostr\u00f3 una asociaci\u00f3n enriquecida con las enfermedades relacionadas con el envejecimiento, incluida la enfermedad de las arterias coronarias, la arteriosclerosis y las leucemias. 2% (110\/353) de estos CpG y transcripci\u00f3n en 81,7% (139\/170) de genes vecinos de CpG de reloj epigen\u00e9tico.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zannas, A. S., Arloth, J., Carrillo-Roa, T., Iurato, S., R\u00f6h, S., Ressler, K. J., &#8230; &amp; Menke, A. (2015).\u00a0Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.\u00a0Genome biology, 16(1), 1-12. Examinamos el efecto de los factores estresantes de por vida en un reloj epigen\u00e9tico que predice la edad basado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-43716","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;El estr\u00e9s de por vida acelera el envejecimiento epigen\u00e9tico en una cohorte afroamericana urbana: relevancia de la se\u00f1alizaci\u00f3n de glucocorticoides&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43716\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;El estr\u00e9s de por vida acelera el envejecimiento epigen\u00e9tico en una cohorte afroamericana urbana: relevancia de la se\u00f1alizaci\u00f3n de glucocorticoides&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zannas, A. S., Arloth, J., Carrillo-Roa, T., Iurato, S., R\u00f6h, S., Ressler, K. J., &#8230; &amp; Menke, A. (2015).\u00a0Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling.\u00a0Genome biology, 16(1), 1-12. 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