{"id":43909,"date":"2020-09-02T10:30:12","date_gmt":"2020-09-02T08:30:12","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43909"},"modified":"2020-09-02T10:09:42","modified_gmt":"2020-09-02T08:09:42","slug":"43909","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43909","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa senescencia celular irreversible inducida por la exposici\u00f3n prolongada al H 2 O 2 involucra genes de reparaci\u00f3n y da\u00f1o del ADN y acortamiento de los tel\u00f3meros\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-6G--I0f0BXo\/X09Sm_PnjBI\/AAAAAAAAfk0\/KWVjo3c2-JQP1rn0rHxsQz8saxn3xmh8wCLcBGAsYHQ\/s1600\/International_Journal%2Bof%2BBiochemistry%2B%2526%2BCell%2BBiology.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-6G--I0f0BXo\/X09Sm_PnjBI\/AAAAAAAAfk0\/KWVjo3c2-JQP1rn0rHxsQz8saxn3xmh8wCLcBGAsYHQ\/s320\/International_Journal%2Bof%2BBiochemistry%2B%2526%2BCell%2BBiology.jpg\" width=\"240\" height=\"320\" border=\"0\" data-original-width=\"576\" data-original-height=\"768\" \/><\/a>Duan, J., Duan, J., Zhang, Z., &amp; Tong, T. (2005).\u00a0<a href=\"https:\/\/scholar.google.com\/scholar_url?url=https:\/\/www.researchgate.net\/profile\/Biswajit_Majumder6\/post\/Protocols_for_inducing_oxidative_stress_in_cell_cultures\/attachment\/59d64d8f79197b80779a7175\/AS:488753929166848%401493539425748\/download\/2005001.pdf&amp;hl=es&amp;sa=T&amp;oi=gsb-gga&amp;ct=res&amp;cd=0&amp;d=10755207449673437700&amp;ei=qFFPX7-bNr2Ay9YPsrSewA8&amp;scisig=AAGBfm2TqwOa0zyDhdZSIDdfs_naruhA1w\">Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening<\/a>.\u00a0<i>The international journal of biochemistry &amp; cell biology<\/i>, 37(7), 1407-1420.<\/p>\n<p>El H2O2 ha sido el inductor m\u00e1s utilizado para la senescencia prematura inducida por estr\u00e9s (SIPS), que comparte caracter\u00edsticas de senescencia replicativa. Sin embargo, todav\u00eda hay incertidumbre sobre si el SIPS y la senescencia replicativa difieren o utilizan diferentes v\u00edas.<\/p>\n<p>Los fibroblastos diploides humanos (HDF) &#8216;j\u00f3venes&#8217; , tratados con dosis bajas prolongadas de per\u00f3xido de hidr\u00f3geno , condujeron a una senescencia celular irreversible. Las c\u00e9lulas exhibieron caracter\u00edsticas morfol\u00f3gicas senescentes, detenci\u00f3n irreversible del ciclo celular G1 y positividad de \u03b2-galactosidasa asociada a senescencia irreversible.<\/p>\n<p>La aparici\u00f3n de estos marcadores de senescencia celular se acompa\u00f1\u00f3 de aumentos significativos de p21 , gadd45expresi\u00f3n y actividad de uni\u00f3n de p53 , as\u00ed como una disminuci\u00f3n significativa en la capacidad de reparaci\u00f3n del ADN yacortamientoacelerado de lostel\u00f3meros. Nuestros resultados sugieren que m\u00faltiples v\u00edas podr\u00edan estar involucradas en SIPS oxidativo, incluidos genes relacionados con el da\u00f1o y reparaci\u00f3n del ADN y el acortamiento de los tel\u00f3meros, y que SIPS comparte los mismos mecanismos con la senescencia replicativa in vivo.<\/p>\n<div>Nuestros hallazgos indican que varias teor\u00edas del envejecimiento pueden fusionarse mediante un mecanismo com\u00fan de da\u00f1o oxidativo, y que el nivel de capacidad oxidativa de da\u00f1o y reparaci\u00f3n del ADN puede explotarse como marcadores confiables de la senescencia celular.<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Duan, J., Duan, J., Zhang, Z., &amp; Tong, T. (2005).\u00a0Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening.\u00a0The international journal of biochemistry &amp; cell biology, 37(7), 1407-1420. El H2O2 ha sido el inductor m\u00e1s utilizado para la senescencia prematura inducida por estr\u00e9s (SIPS), que comparte caracter\u00edsticas de senescencia replicativa. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-43909","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La senescencia celular irreversible inducida por la exposici\u00f3n prolongada al H 2 O 2 involucra genes de reparaci\u00f3n y da\u00f1o del ADN y acortamiento de los tel\u00f3meros&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43909\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La senescencia celular irreversible inducida por la exposici\u00f3n prolongada al H 2 O 2 involucra genes de reparaci\u00f3n y da\u00f1o del ADN y acortamiento de los tel\u00f3meros&quot; -\" \/>\n<meta property=\"og:description\" content=\"Duan, J., Duan, J., Zhang, Z., &amp; Tong, T. (2005).\u00a0Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening.\u00a0The international journal of biochemistry &amp; cell biology, 37(7), 1407-1420. El H2O2 ha sido el inductor m\u00e1s utilizado para la senescencia prematura inducida por estr\u00e9s (SIPS), que comparte caracter\u00edsticas de senescencia replicativa. 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