{"id":43938,"date":"2020-09-04T04:30:05","date_gmt":"2020-09-04T02:30:05","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43938"},"modified":"2020-09-06T10:13:17","modified_gmt":"2020-09-06T08:13:17","slug":"43938","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43938","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Interacciones: \u00abLos flavonoides de la dieta inhiben los efectos anticancer\u00edgenos del inhibidor del proteasoma bortezomib\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-ByGhUbVpROA\/X1SZPLr--wI\/AAAAAAAAfnk\/ft3pjTlTOzcgvqL0vinbZ9txCFpEc1OnwCLcBGAsYHQ\/s1600\/Blood.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-ByGhUbVpROA\/X1SZPLr--wI\/AAAAAAAAfnk\/ft3pjTlTOzcgvqL0vinbZ9txCFpEc1OnwCLcBGAsYHQ\/s1600\/Blood.jpg\" border=\"0\" data-original-width=\"176\" data-original-height=\"240\" \/><\/a>Liu, F. T., Agrawal, S. G., Movasaghi, Z., Wyatt, P. B., Rehman, I. U., Gribben, J. G., &#8230; &amp; Jia, L. (2008).\u00a0<a href=\"https:\/\/ashpublications.org\/blood\/article\/112\/9\/3835\/125939\/Dietary-flavonoids-inhibit-the-anticancer-effects\">Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.<\/a>\u00a0<i>Blood<\/i>, 112(9), 3835-3846.<\/p>\n<p>Los flavonoides de la dieta tienen muchas acciones que promueven la salud, incluida la actividad anticancerosa a trav\u00e9s de la inhibici\u00f3n del proteasoma. Bortezomib es un inhibidor del proteasoma de boronato dip\u00e9ptido que tiene actividad en el tratamiento del mieloma m\u00faltiple, pero no es eficaz en la leucemia linfoc\u00edtica cr\u00f3nica (LLC). Aunque las c\u00e9lulas de LLC son sensibles in vitro a la apoptosis inducida por bortezomib cuando se cultivan en medio, la actividad destructora se bloque\u00f3 cuando se cultivaron en plasma aut\u00f3logo fresco al 50%.<\/p>\n<p>Los flavonoides de la dieta, quercetina y miricetina, que son abundantes en el plasma, inhibieron la apoptosis inducida por bortezomib de la CLL primaria y las l\u00edneas de c\u00e9lulas B malignas de una manera dependiente de la dosis. Este efecto inhibidor se asoci\u00f3 con reacciones qu\u00edmicas entre la quercetina y el grupo del \u00e1cido bor\u00f3nico, -RB (OH) 2, en bortezomib.<\/p>\n<p>La adici\u00f3n de \u00e1cido b\u00f3rico disminuy\u00f3 el efecto inhibidor tanto de la quercetina como del plasma sobre la apoptosis inducida por bortezomib. El efecto protector tambi\u00e9n se redujo cuando las l\u00edneas de c\u00e9lulas de mieloma, pero no las l\u00edneas de c\u00e9lulas B, se preincubaron con quercetina, lo que indica un efecto directo de la quercetina sobre las c\u00e9lulas de mieloma. En dosis altas, la quercetina por s\u00ed misma indujo la muerte de las c\u00e9lulas tumorales.<\/p>\n<p>Estos datos indican que los flavonoides de la dieta limitan la eficacia de bortezomib, mientras que el \u00e1cido b\u00f3rico inorg\u00e1nico suplementario puede revertir esto. Las complejas interacciones entre la quercetina, las c\u00e9lulas tumorales y el bortezomib significan que se requiere precauci\u00f3n al dar consejos diet\u00e9ticos a los pacientes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liu, F. T., Agrawal, S. G., Movasaghi, Z., Wyatt, P. B., Rehman, I. U., Gribben, J. G., &#8230; &amp; Jia, L. (2008).\u00a0Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.\u00a0Blood, 112(9), 3835-3846. Los flavonoides de la dieta tienen muchas acciones que promueven la salud, incluida la actividad anticancerosa a trav\u00e9s de la inhibici\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-43938","post","type-post","status-publish","format-standard","hentry","category-interacciones"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Interacciones: &quot;Los flavonoides de la dieta inhiben los efectos anticancer\u00edgenos del inhibidor del proteasoma bortezomib&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43938\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Interacciones: &quot;Los flavonoides de la dieta inhiben los efectos anticancer\u00edgenos del inhibidor del proteasoma bortezomib&quot; -\" \/>\n<meta property=\"og:description\" content=\"Liu, F. T., Agrawal, S. G., Movasaghi, Z., Wyatt, P. B., Rehman, I. U., Gribben, J. G., &#8230; &amp; Jia, L. (2008).\u00a0Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.\u00a0Blood, 112(9), 3835-3846. Los flavonoides de la dieta tienen muchas acciones que promueven la salud, incluida la actividad anticancerosa a trav\u00e9s de la inhibici\u00f3n [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43938\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-04T02:30:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-06T08:13:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-ByGhUbVpROA\/X1SZPLr--wI\/AAAAAAAAfnk\/ft3pjTlTOzcgvqL0vinbZ9txCFpEc1OnwCLcBGAsYHQ\/s1600\/Blood.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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