{"id":43944,"date":"2020-09-04T06:30:13","date_gmt":"2020-09-04T04:30:13","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=43944"},"modified":"2020-09-06T10:38:53","modified_gmt":"2020-09-06T08:38:53","slug":"43944","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=43944","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfectos de los flavonoides quercetina y apigenina sobre la hemostasia en voluntarios sanos: resultados de un estudio in vitro y de suplementos diet\u00e9ticos\u00bb"},"content":{"rendered":"

<\/a>Janssen, K. P. L. T. M., Mensink, R. P., Cox, F. J., Harryvan, J. L., Hovenier, R., Hollman, P. C., & Katan, M. B. (1998).\u00a0Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study<\/a>.\u00a0The American journal of clinical nutrition<\/i>, 67(2), 255-262.<\/p>\n

La ingesta de flavonoles y flavonas en la dieta se asoci\u00f3 inversamente con el riesgo de enfermedad cardiovascular en varios estudios epidemiol\u00f3gicos. Esto puede deberse a efectos sobre la hemostasia porque se ha informado que los flavonoides inhiben la agregaci\u00f3n plaquetaria in vitro. De hecho, encontramos que 2500 micromol \/ L del flavonol quercetina y la flavona apigenina inhibieron significativamente la agregaci\u00f3n inducida por col\u00e1geno y ADP en plasma rico en plaquetas y plaquetas lavadas en aproximadamente un 80-97%. Sin embargo, concentraciones m\u00e1s bajas, como las que podr\u00edan ocurrir in vivo, no tuvieron ning\u00fan efecto.<\/p>\n

Para probar esto in vivo, alimentamos a 18 voluntarios sanos con 220 g de cebollas \/ d que proporcionaban 114 mg de quercetina \/ d, 5 g de perejil seco \/ d que proporcionaban 84 mg de apigenina \/ d, o un placebo durante 7 d cada uno en un experimento cruzado aleatorio con cada tratamiento. per\u00edodo que dura 2 semanas.<\/p>\n

El consumo de cebolla elev\u00f3 las concentraciones plasm\u00e1ticas medias de quercetina a 1,5 micromol \/ L; no se pudo medir la apigenina plasm\u00e1tica. No se encontraron efectos significativos de las cebollas o el perejil sobre la agregaci\u00f3n plaquetaria, la producci\u00f3n de tromboxano B2, el factor VII u otras variables hemost\u00e1ticas.<\/p>\n

CONCLUSI\u00d3N: Concluimos que los efectos antiagregantes de los flavonoides observados in vitro se deben a concentraciones que no se pueden alcanzar in vivo. Los efectos de los flavonoles y flavonas de la dieta sobre el riesgo cardiovascular posiblemente no est\u00e9n mediados por variables hemost\u00e1ticas.<\/p>\n","protected":false},"excerpt":{"rendered":"

Janssen, K. P. L. T. M., Mensink, R. P., Cox, F. J., Harryvan, J. L., Hovenier, R., Hollman, P. C., & Katan, M. B. (1998).\u00a0Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study.\u00a0The American journal of clinical nutrition, 67(2), 255-262. La ingesta […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-43944","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"\n\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "Efectos de los flavonoides quercetina y apigenina sobre la hemostasia en voluntarios sanos: resultados de un estudio in vitro y de suplementos diet\u00e9ticos" -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=43944\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: "Efectos de los flavonoides quercetina y apigenina sobre la hemostasia en voluntarios sanos: resultados de un estudio in vitro y de suplementos diet\u00e9ticos" -\" \/>\n<meta property=\"og:description\" content=\"Janssen, K. P. L. T. M., Mensink, R. P., Cox, F. J., Harryvan, J. L., Hovenier, R., Hollman, P. C., & Katan, M. B. (1998).\u00a0Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study.\u00a0The American journal of clinical nutrition, 67(2), 255-262. La ingesta […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=43944\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-04T04:30:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-06T08:38:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-IxQ2Tsv8LAE\/X1Se7uYTGTI\/AAAAAAAAfn8\/aIih4F2mNqoSgg3r_v8L5opQUkV4TftwQCLcBGAsYHQ\/s320\/American_journal%2Bof%2Bclinical%2Bnutrition2.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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