{"id":44013,"date":"2020-09-09T00:30:17","date_gmt":"2020-09-08T22:30:17","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44013"},"modified":"2020-09-10T10:58:13","modified_gmt":"2020-09-10T08:58:13","slug":"44013","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44013","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa expresi\u00f3n elevada de aromatasa se correlaciona con la progresi\u00f3n del carcinoma cervical\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-aA1FdPYhM98\/X1nqIjoc_MI\/AAAAAAAAfr0\/uhTROgcEm6cgm0kcOLbeCX8LejiBbAMDQCLcBGAsYHQ\/s1600\/Gynecologic_Oncology.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-aA1FdPYhM98\/X1nqIjoc_MI\/AAAAAAAAfr0\/uhTROgcEm6cgm0kcOLbeCX8LejiBbAMDQCLcBGAsYHQ\/s1600\/Gynecologic_Oncology.gif\" border=\"0\" data-original-width=\"240\" data-original-height=\"320\" \/><\/a>Veerapaneni, P., Kirma, N., Nair, H. B., Hammes, L. S., Hall, K. L., &amp; Tekmal, R. R. (2009).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0090825809004132\">Elevated aromatase expression correlates with cervical carcinoma progression<\/a>.\u00a0<i>Gynecologic oncology<\/i>, 114(3), 496-500.<\/p>\n<p>OBJETIVOS: Hemos demostrado previamente que el ARNm de la aromatasa se induce en los carcinomas de cuello uterino en comparaci\u00f3n con el tejido normal, lo que sugiere que la expresi\u00f3n de aromatasa in situ que conduce a una producci\u00f3n local elevada de estr\u00f3genos puede contribuir a la carcinog\u00e9nesis cervical. Nuestros objetivos son examinar 1) si la prote\u00edna y la actividad de la aromatasa se inducen en los carcinomas de cuello uterino, 2) la expresi\u00f3n de la aromatasa se correlaciona con el estadio de la enfermedad y 3) las citocinas inflamatorias (por ejemplo, IL-6 y TNF\u03b1) pueden correlacionarse con la expresi\u00f3n de la aromatasa.<\/p>\n<p>M\u00c9TODOS: Se aislaron ARN y prote\u00ednas de carcinomas cervicales humanos y biopsias cervicales normales para examinar la expresi\u00f3n de la aromatasa, utilizando RT-PCR en tiempo real, an\u00e1lisis de transferencia Western e inmunohistoqu\u00edmica. La actividad de la aromatasa en el tejido se midi\u00f3 utilizando el m\u00e9todo de liberaci\u00f3n de agua tritiada. Tambi\u00e9n se examin\u00f3 la expresi\u00f3n de IL-6 y TNF\u03b1.<\/p>\n<p>RESULTADOS: La prote\u00edna aromatasa y los niveles de actividad aumentaron en los carcinomas de cuello uterino en comparaci\u00f3n con el tejido normal. Los niveles de ARN se correlacionaron significativamente con la progresi\u00f3n de la enfermedad, con la m\u00e1xima expresi\u00f3n de aromatasa detectada en tumores en estadio IV (p &lt;0,001, R2 = 0,77). Los promotores de aromatasa 1.3 y 1.4 estaban elevados en carcinomas de cuello uterino y en c\u00e9lulas de c\u00e1ncer de cuello uterino. La expresi\u00f3n de citocinas inflamatorias IL-6 y TNF\u03b1, conocidas por inducir aromatasa, se correlacion\u00f3 significativamente con la expresi\u00f3n de aromatasa (R2&gt; 0,9). El tratamiento con TNF\u03b1 indujo la expresi\u00f3n de aromatasa en c\u00e9lulas de c\u00e1ncer de cuello uterino.<\/p>\n<p>CONCLUSION: El aumento de la actividad y de la prote\u00edna aromatasa en los carcinomas de cuello uterino y la correlaci\u00f3n de su expresi\u00f3n con el estadio de la enfermedad la implica en la carcinog\u00e9nesis cervical. La correlaci\u00f3n de la expresi\u00f3n de IL-6 y TNF\u03b1 con la aromatasa sugiere que estas citocinas inflamatorias pueden inducir la expresi\u00f3n de la aromatasa, lo que se confirma mediante la inducci\u00f3n de la expresi\u00f3n de la aromatasa debido al tratamiento con TNF\u03b1 de las c\u00e9lulas de c\u00e1ncer de cuello uterino.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Veerapaneni, P., Kirma, N., Nair, H. B., Hammes, L. S., Hall, K. L., &amp; Tekmal, R. R. (2009).\u00a0Elevated aromatase expression correlates with cervical carcinoma progression.\u00a0Gynecologic oncology, 114(3), 496-500. OBJETIVOS: Hemos demostrado previamente que el ARNm de la aromatasa se induce en los carcinomas de cuello uterino en comparaci\u00f3n con el tejido normal, lo que sugiere [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-44013","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La expresi\u00f3n elevada de aromatasa se correlaciona con la progresi\u00f3n del carcinoma cervical&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44013\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La expresi\u00f3n elevada de aromatasa se correlaciona con la progresi\u00f3n del carcinoma cervical&quot; -\" \/>\n<meta property=\"og:description\" content=\"Veerapaneni, P., Kirma, N., Nair, H. B., Hammes, L. S., Hall, K. L., &amp; Tekmal, R. R. (2009).\u00a0Elevated aromatase expression correlates with cervical carcinoma progression.\u00a0Gynecologic oncology, 114(3), 496-500. OBJETIVOS: Hemos demostrado previamente que el ARNm de la aromatasa se induce en los carcinomas de cuello uterino en comparaci\u00f3n con el tejido normal, lo que sugiere [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44013\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-08T22:30:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-10T08:58:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-aA1FdPYhM98\/X1nqIjoc_MI\/AAAAAAAAfr0\/uhTROgcEm6cgm0kcOLbeCX8LejiBbAMDQCLcBGAsYHQ\/s1600\/Gynecologic_Oncology.gif\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script 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