{"id":44027,"date":"2020-09-14T01:30:42","date_gmt":"2020-09-13T23:30:42","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44027"},"modified":"2020-09-14T15:26:53","modified_gmt":"2020-09-14T13:26:53","slug":"area-de-conocimiento-naturopatia-descriptiva-la-replicacion-del-virus-de-la-gripe-a-depende-de-una-via-antioxidante-que-involucra-a-gsh-y-bcl-2-2","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44027","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa replicaci\u00f3n del virus de la gripe A depende de una v\u00eda antioxidante que involucra a GSH y Bcl-2\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-4JOOgrJhMKE\/X19u9HfL46I\/AAAAAAAAfsw\/cEW2FIZdW_ku4C9K4ATbFTfbIbzyz5X3wCLcBGAsYHQ\/s1600\/FASEB2.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-4JOOgrJhMKE\/X19u9HfL46I\/AAAAAAAAfsw\/cEW2FIZdW_ku4C9K4ATbFTfbIbzyz5X3wCLcBGAsYHQ\/s320\/FASEB2.jpg\" width=\"233\" height=\"320\" border=\"0\" data-original-width=\"270\" data-original-height=\"370\" \/><\/a>Nencioni, L., Iuvara, A., Aquilano, K., Ciriolo, M. R., Cozzolino, F., Rotilio, G., &#8230; &amp; Palamara, A. T. (2003).\u00a0<a href=\"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.02-0508fje\">Influenza A virus replication is dependent on an antioxidant pathway that involves GSH and Bcl\u20102<\/a>.\u00a0<i>The FASEB Journal<\/i>, 17(6), 758-760.<\/p>\n<p>La creciente evidencia indica que la replicaci\u00f3n viral est\u00e1 regulada por el estado redox de la c\u00e9lula hu\u00e9sped. Demostramos que las c\u00e9lulas de diferentes or\u00edgenes muestran una permisividad diferencial para la replicaci\u00f3n del virus de la gripe A, dependiendo de su poder redox intracelular reflejado por la expresi\u00f3n de Bcl-2 y el contenido de glutati\u00f3n (GSH).<\/p>\n<p>Se encontr\u00f3 que las c\u00e9lulas que expresan Bcl-2 tienen niveles intracelulares m\u00e1s altos de GSH y producen cantidades menores de virus que las c\u00e9lulas negativas para Bcl-2. En la inhibici\u00f3n viral mediada por Bcl-2 \/ GSH estaban implicadas dos etapas diferentes en el ciclo de vida del virus: 1) expresi\u00f3n de prote\u00ednas virales tard\u00edas (en particular hemaglutinina y matriz); y 2) translocaci\u00f3n citopl\u00e1smica nuclear de ribonucleoprote\u00ednas virales (vRNP).<\/p>\n<p>La inhibici\u00f3n inducida por butionina-sulfoximina de la s\u00edntesis de GSH en c\u00e9lulas que expresan Bcl-2 provoc\u00f3 un aumento en la expresi\u00f3n de prote\u00ednas virales tard\u00edas pero no restaur\u00f3 la exportaci\u00f3n de vRNP al citoplasma.<\/p>\n<p>En conjunto, nuestros hallazgos muestran que tanto la expresi\u00f3n de Bcl-2 como el contenido de GSH contribuyen a la capacidad de la c\u00e9lula hu\u00e9sped para regular negativamente la replicaci\u00f3n del virus de la gripe, aunque sus efectos se ejercen en diferentes etapas del ciclo de vida viral. En determinadas poblaciones de c\u00e9lulas, esta forma de regulaci\u00f3n a la baja podr\u00eda posiblemente favorecer el establecimiento de una infecci\u00f3n viral persistente. aunque sus efectos se ejercen en diferentes etapas del ciclo de vida viral.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nencioni, L., Iuvara, A., Aquilano, K., Ciriolo, M. R., Cozzolino, F., Rotilio, G., &#8230; &amp; Palamara, A. T. (2003).\u00a0Influenza A virus replication is dependent on an antioxidant pathway that involves GSH and Bcl\u20102.\u00a0The FASEB Journal, 17(6), 758-760. La creciente evidencia indica que la replicaci\u00f3n viral est\u00e1 regulada por el estado redox de la c\u00e9lula hu\u00e9sped. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-44027","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La replicaci\u00f3n del virus de la gripe A depende de una v\u00eda antioxidante que involucra a GSH y Bcl-2&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44027\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La replicaci\u00f3n del virus de la gripe A depende de una v\u00eda antioxidante que involucra a GSH y Bcl-2&quot; -\" \/>\n<meta property=\"og:description\" content=\"Nencioni, L., Iuvara, A., Aquilano, K., Ciriolo, M. 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