{"id":44068,"date":"2020-09-17T06:30:37","date_gmt":"2020-09-17T04:30:37","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44068"},"modified":"2020-09-19T20:03:19","modified_gmt":"2020-09-19T18:03:19","slug":"44068","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44068","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPolifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-NcNrUd9ka7g\/X2YX6GbITeI\/AAAAAAAAfvE\/HdHIetQ0KJcZIgoy7wSb4qEyN49zrs6JQCLcBGAsYHQ\/s240\/personalized_nutrition.PNG\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-NcNrUd9ka7g\/X2YX6GbITeI\/AAAAAAAAfvE\/HdHIetQ0KJcZIgoy7wSb4qEyN49zrs6JQCLcBGAsYHQ\/s0\/personalized_nutrition.PNG\" border=\"0\" data-original-height=\"240\" data-original-width=\"187\" \/><\/a>Rahman, I., &amp; Chung, S. (2010).\u00a0<a href=\"https:\/\/library.oapen.org\/bitstream\/handle\/20.500.12657\/25858\/1004228.pdf?sequence=1#page=105\">Dietary polyphenols, deacetylases and chromatin remodeling in inflammation<\/a>. In\u00a0<i>Personalized Nutrition<\/i>\u00a0(Vol. 101, pp. 84-94). Karger Publishers.<\/p>\n<p>Los beneficios terap\u00e9uticos de las frutas, verduras, t\u00e9 y vino se atribuyen principalmente a la presencia de compuestos fen\u00f3licos. Los polifenoles diet\u00e9ticos naturales, como la curcumina (diferuloilmetano, un componente activo de la c\u00farcuma especia) y el resveratrol (fitoalexina, un fiavanoide que se encuentra en el vino tinto) pueden modular las v\u00edas de se\u00f1alizaci\u00f3n mediadas a trav\u00e9s de NF-\u03baB y MAP quinasa, y regular positivamente los genes de bios\u00edntesis de glutati\u00f3n mediante la activaci\u00f3n de Nrf2.<\/p>\n<p>Los polifenoles tambi\u00e9n regulan negativamente la expresi\u00f3n de mediadores proinflamatorios, metaloproteinasas de matriz y mol\u00e9culas de adhesi\u00f3n inhibiendo la actividad de la histona acetiltransferasa (HAT) y activando las histonas desacetilasas (HDAC) \/ sirtuinas.<\/p>\n<p>Se ha informado que en pacientes con asma grave y con enfermedad pulmonar obstructiva cr\u00f3nica (EPOC), el estr\u00e9s oxidativo no solo activa la v\u00eda NF-\u03baB, sino que tambi\u00e9n altera el equilibrio de acetilaci\u00f3n y desacetilaci\u00f3n de histonas mediante modificaciones postraduccionales de las HDAC. Los corticosteroides han sido uno de los principales modos de tratamiento contra diversas enfermedades respiratorias, como el asma y la EPOC. El fracaso de los corticosteroides para mejorar estas enfermedades se debe a la reducci\u00f3n de los niveles \/ actividades de HDAC2 y SIRT1 en los pulmones de los pacientes asm\u00e1ticos y con EPOC.<\/p>\n<p>Se ha informado que los polifenoles de la dieta, como la curcumina, el resveratrol y las catequinas, modulan las alteraciones epigen\u00e9ticas en varios modelos experimentales. La propiedad antiinflamatoria de la curcumina, el resveratrol y las catequinas est\u00e1 asociada con su capacidad para inducir la actividad de HDAC y, por lo tanto, restaurar la eficacia de los glucocorticoides o superar su resistencia. As\u00ed, estos compuestos polifen\u00f3licos tienen valor terap\u00e9utico como antioxidantes, terapia antiinflamatoria y terapia adyuvante con esteroides contra enfermedades cr\u00f3nicas inflamatorias y reguladas epigen\u00e9ticamente.<\/p>\n<p>En este cap\u00edtulo presentamos los conocimientos actuales sobre el modo de acci\u00f3n de estos polifenoles a la luz de las HDAC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rahman, I., &amp; Chung, S. (2010).\u00a0Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. In\u00a0Personalized Nutrition\u00a0(Vol. 101, pp. 84-94). Karger Publishers. Los beneficios terap\u00e9uticos de las frutas, verduras, t\u00e9 y vino se atribuyen principalmente a la presencia de compuestos fen\u00f3licos. Los polifenoles diet\u00e9ticos naturales, como la curcumina (diferuloilmetano, un componente activo de la c\u00farcuma especia) y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44068","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Polifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44068\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Polifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n&quot; -\" \/>\n<meta property=\"og:description\" content=\"Rahman, I., &amp; Chung, S. (2010).\u00a0Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. In\u00a0Personalized Nutrition\u00a0(Vol. 101, pp. 84-94). Karger Publishers. Los beneficios terap\u00e9uticos de las frutas, verduras, t\u00e9 y vino se atribuyen principalmente a la presencia de compuestos fen\u00f3licos. Los polifenoles diet\u00e9ticos naturales, como la curcumina (diferuloilmetano, un componente activo de la c\u00farcuma especia) y [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44068\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-17T04:30:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-09-19T18:03:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-NcNrUd9ka7g\/X2YX6GbITeI\/AAAAAAAAfvE\/HdHIetQ0KJcZIgoy7wSb4qEyN49zrs6JQCLcBGAsYHQ\/s0\/personalized_nutrition.PNG\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44068#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44068\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPolifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\u00bb\",\"datePublished\":\"2020-09-17T04:30:37+00:00\",\"dateModified\":\"2020-09-19T18:03:19+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44068\"},\"wordCount\":382,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=44068#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44068\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44068\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"Polifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-09-17T04:30:37+00:00\",\"dateModified\":\"2020-09-19T18:03:19+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44068#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=44068\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44068#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPolifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Polifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=44068","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Polifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\" -","og_description":"Rahman, I., &amp; Chung, S. (2010).\u00a0Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. In\u00a0Personalized Nutrition\u00a0(Vol. 101, pp. 84-94). Karger Publishers. Los beneficios terap\u00e9uticos de las frutas, verduras, t\u00e9 y vino se atribuyen principalmente a la presencia de compuestos fen\u00f3licos. Los polifenoles diet\u00e9ticos naturales, como la curcumina (diferuloilmetano, un componente activo de la c\u00farcuma especia) y [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=44068","article_published_time":"2020-09-17T04:30:37+00:00","article_modified_time":"2020-09-19T18:03:19+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-NcNrUd9ka7g\/X2YX6GbITeI\/AAAAAAAAfvE\/HdHIetQ0KJcZIgoy7wSb4qEyN49zrs6JQCLcBGAsYHQ\/s0\/personalized_nutrition.PNG"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44068#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44068"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPolifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\u00bb","datePublished":"2020-09-17T04:30:37+00:00","dateModified":"2020-09-19T18:03:19+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44068"},"wordCount":382,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=44068#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44068","url":"https:\/\/rina.naturopatiadigital.eu\/?p=44068","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Polifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-09-17T04:30:37+00:00","dateModified":"2020-09-19T18:03:19+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44068#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=44068"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44068#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPolifenoles diet\u00e9ticos, desacetilasas y remodelaci\u00f3n de cromatina en la inflamaci\u00f3n\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44068","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44068"}],"version-history":[{"count":2,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44068\/revisions"}],"predecessor-version":[{"id":44070,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44068\/revisions\/44070"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44068"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44068"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}