{"id":44095,"date":"2020-09-18T01:30:26","date_gmt":"2020-09-17T23:30:26","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44095"},"modified":"2020-10-02T22:21:01","modified_gmt":"2020-10-02T20:21:01","slug":"44095","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44095","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-OkqX1PkVBHk\/X29EPEjzeUI\/AAAAAAAAfyM\/dBfNx9ftP6US4y6JZHj_DjkKSfz-lfrNQCLcBGAsYHQ\/s204\/Apoptosis.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-OkqX1PkVBHk\/X29EPEjzeUI\/AAAAAAAAfyM\/dBfNx9ftP6US4y6JZHj_DjkKSfz-lfrNQCLcBGAsYHQ\/s0\/Apoptosis.jpg\" border=\"0\" data-original-height=\"204\" data-original-width=\"153\" \/><\/a>S\u00e1nchez, A. M., Malagarie-Cazenave, S., Olea, N., Vara, D., Chiloeches, A., &amp; D\u00edaz-Laviada, I. (2007). <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10495-007-0119-z\">Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation<\/a>.\u00a0<i>Apoptosis<\/i>, 12(11), 2013-2024.<\/p>\n<p>CONTEXTO: Numerosos estudios se han centrado recientemente en las actividades anticancer\u00edgenas, antimutag\u00e9nicas o quimiopreventivas del principal componente picante del pimiento rojo, la capsaicina ( N-vanilil-8-metil-1-nonenamida). Anteriormente hemos demostrado que, en las c\u00e9lulas PC-3 de c\u00e1ncer de pr\u00f3stata independientes de andr\u00f3genos, la capsaicina inhibe el crecimiento celular e induce la apoptosis a trav\u00e9s de la generaci\u00f3n de especies reactivas de ox\u00edgeno (ROS) [Apoptosis 11 (2006) 89-99].<\/p>\n<p>OBJETIVO: En el presente estudio, investigamos las v\u00edas de se\u00f1alizaci\u00f3n implicadas en el efecto antiproliferativo de la capsaicina.<\/p>\n<p>M\u00c9TODOS \/ RESULTADOSAqu\u00ed, informamos que el efecto apopt\u00f3tico de la capsaicina fue mediado por la generaci\u00f3n de ceramida que ocurri\u00f3 por hidr\u00f3lisis de esfingomielina. Usando siRNA, demostramos que la expresi\u00f3n de N-SMasa es necesaria para el efecto de la capsaicina en la viabilidad de las c\u00e9lulas prost\u00e1ticas. Luego investigamos el papel de las cascadas de MAP quinasa, la prote\u00edna quinasa regulada por se\u00f1ales extracelulares (ERK), la quinasa c-Jun N-terminal (JNK) y la p38 MAPK, en el efecto antiproliferativo de la capsaicina, y confirmamos que la capsaicina podr\u00eda activar ERK y JNK pero no p38 MAPK. Inhibici\u00f3n farmacol\u00f3gica de la cinasa JNK, as\u00ed como inhibici\u00f3n de ROS por el agente reductorN -acetilciste\u00edna, previno la acumulaci\u00f3n de ceramida y la muerte celular inducida por capsaicina. Sin embargo, la inhibici\u00f3n de la acumulaci\u00f3n de ceramida por el inhibidor de SMasa D609 no modific\u00f3 la activaci\u00f3n de JNK. Estos datos revelan a JNK como un regulador anterior de la producci\u00f3n de ceramidas. La activaci\u00f3n de ERK promovida por capsaicina se evit\u00f3 con todos los inhibidores probados.<\/p>\n<p>CONCLUSI\u00d3N: Concluimos que la capsaicina induce la apoptosis en las c\u00e9lulas PC-3 a trav\u00e9s de la generaci\u00f3n de ROS, la activaci\u00f3n de JNK, la acumulaci\u00f3n de ceramida y, en segundo lugar, la activaci\u00f3n de ERK.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>S\u00e1nchez, A. M., Malagarie-Cazenave, S., Olea, N., Vara, D., Chiloeches, A., &amp; D\u00edaz-Laviada, I. (2007). Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation.\u00a0Apoptosis, 12(11), 2013-2024. CONTEXTO: Numerosos estudios se han centrado recientemente en las actividades anticancer\u00edgenas, antimutag\u00e9nicas o quimiopreventivas del principal componente picante del pimiento rojo, la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44095","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44095\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK&quot; -\" \/>\n<meta property=\"og:description\" content=\"S\u00e1nchez, A. M., Malagarie-Cazenave, S., Olea, N., Vara, D., Chiloeches, A., &amp; D\u00edaz-Laviada, I. (2007). Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation.\u00a0Apoptosis, 12(11), 2013-2024. CONTEXTO: Numerosos estudios se han centrado recientemente en las actividades anticancer\u00edgenas, antimutag\u00e9nicas o quimiopreventivas del principal componente picante del pimiento rojo, la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44095\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-17T23:30:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-02T20:21:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-OkqX1PkVBHk\/X29EPEjzeUI\/AAAAAAAAfyM\/dBfNx9ftP6US4y6JZHj_DjkKSfz-lfrNQCLcBGAsYHQ\/s0\/Apoptosis.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44095#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44095\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\u00bb\",\"datePublished\":\"2020-09-17T23:30:26+00:00\",\"dateModified\":\"2020-10-02T20:21:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44095\"},\"wordCount\":398,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=44095#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44095\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44095\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"La apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-09-17T23:30:26+00:00\",\"dateModified\":\"2020-10-02T20:21:01+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44095#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=44095\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44095#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=44095","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\" -","og_description":"S\u00e1nchez, A. M., Malagarie-Cazenave, S., Olea, N., Vara, D., Chiloeches, A., &amp; D\u00edaz-Laviada, I. (2007). Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation.\u00a0Apoptosis, 12(11), 2013-2024. CONTEXTO: Numerosos estudios se han centrado recientemente en las actividades anticancer\u00edgenas, antimutag\u00e9nicas o quimiopreventivas del principal componente picante del pimiento rojo, la [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=44095","article_published_time":"2020-09-17T23:30:26+00:00","article_modified_time":"2020-10-02T20:21:01+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-OkqX1PkVBHk\/X29EPEjzeUI\/AAAAAAAAfyM\/dBfNx9ftP6US4y6JZHj_DjkKSfz-lfrNQCLcBGAsYHQ\/s0\/Apoptosis.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44095#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44095"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\u00bb","datePublished":"2020-09-17T23:30:26+00:00","dateModified":"2020-10-02T20:21:01+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44095"},"wordCount":398,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=44095#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44095","url":"https:\/\/rina.naturopatiadigital.eu\/?p=44095","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-09-17T23:30:26+00:00","dateModified":"2020-10-02T20:21:01+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44095#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=44095"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44095#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa apoptosis inducida por capsaicina en las c\u00e9lulas PC-3 de la pr\u00f3stata implica la acumulaci\u00f3n de ceramida, la esfingomielinasa neutra y la activaci\u00f3n de JNK\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44095"}],"version-history":[{"count":4,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44095\/revisions"}],"predecessor-version":[{"id":44278,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44095\/revisions\/44278"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44095"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44095"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}