{"id":44108,"date":"2020-09-18T05:30:25","date_gmt":"2020-09-18T03:30:25","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44108"},"modified":"2020-10-02T22:16:02","modified_gmt":"2020-10-02T20:16:02","slug":"44108","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44108","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa capsaicina muestra actividad antiproliferativa contra el c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as humanas en cultivos celulares y modelos de ratones desnudos a trav\u00e9s de la v\u00eda E2F\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-h3hBsOaw-pI\/X29j29xR8cI\/AAAAAAAAfzA\/DhylK3UoTnwuHPrQJyNlFPe-3_OAcxO1QCLcBGAsYHQ\/s317\/PLOS_ONE.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-h3hBsOaw-pI\/X29j29xR8cI\/AAAAAAAAfzA\/DhylK3UoTnwuHPrQJyNlFPe-3_OAcxO1QCLcBGAsYHQ\/s0\/PLOS_ONE.jpg\" border=\"0\" data-original-height=\"317\" data-original-width=\"262\" \/><\/a>Brown, K. C., Witte, T. R., Hardman, W. E., Luo, H., Chen, Y. C., Carpenter, A. B., &#8230; &amp; Dasgupta, P. (2010).\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2857654\/\">Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathwa<\/a>y. <em>PLoS one<\/em>, 5(4), e10243.<\/p>\n<p>ANTECEDENTES: El c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as (CPCP) se caracteriza por una r\u00e1pida progresi\u00f3n y bajas tasas de supervivencia. Por tanto, se necesitan urgentemente nuevos agentes terap\u00e9uticos para esta enfermedad. La capsaicina, el ingrediente activo de los chiles, muestra actividad antiproliferativa en el c\u00e1ncer de pr\u00f3stata y epidermoide in vitro . Sin embargo, la actividad antiproliferativa de la capsaicina no se ha estudiado en SCLC humanos. El presente manuscrito llena este vac\u00edo de conocimientos y explora el efecto antiproliferativo de la capsaicina en el CPCP in vitro e in vivo .<\/p>\n<p>METODOLOG\u00cdA \/ PRINCIPALES HALLAZGOS: Los ensayos de BrdU y ELISA de PCNA mostraron que la capsaicina muestra una fuerte actividad antiproliferativa en cuatro l\u00edneas celulares de SCLC humanas. Adem\u00e1s, la capsaicina suprimi\u00f3 de forma potente el crecimiento de tumores SCLC humanos H69 in vivo.como se determin\u00f3 mediante ensayos CAM y modelos de ratones desnudos. La segunda parte de nuestro estudio intent\u00f3 proporcionar informaci\u00f3n sobre los mecanismos moleculares que subyacen a la actividad antiproliferativa de la capsaicina. Encontramos que la actividad antiproliferativa de la capsaicina se correlaciona con una disminuci\u00f3n en la expresi\u00f3n de genes proliferativos sensibles a E2F como la ciclina E, timidilato sintasa, cdc25A y cdc6, tanto a nivel de ARNm como de prote\u00edna. El factor de transcripci\u00f3n E2F4 mediaba la actividad antiproliferativa de la capsaicina. La ablaci\u00f3n de los niveles de E2F4 mediante metodolog\u00eda de ARNip suprimi\u00f3 la detenci\u00f3n de G1 inducida por capsaicina. Los ensayos de ChIP demostraron que la capsaicina provoc\u00f3 el reclutamiento de E2F4 y p130 en los promotores proliferativos que responden a E2F, inhibiendo as\u00ed la proliferaci\u00f3n celular.<\/p>\n<p>CONCLUSIONES \/ IMPORTANCIA: Nuestros hallazgos sugieren que los efectos antiproliferativos de la capsaicina podr\u00edan ser \u00fatiles en la terapia de SCLC humanos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brown, K. C., Witte, T. R., Hardman, W. E., Luo, H., Chen, Y. C., Carpenter, A. B., &#8230; &amp; Dasgupta, P. (2010).\u00a0Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS one, 5(4), e10243. ANTECEDENTES: El c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as (CPCP) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44108","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina muestra actividad antiproliferativa contra el c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as humanas en cultivos celulares y modelos de ratones desnudos a trav\u00e9s de la v\u00eda E2F&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44108\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La capsaicina muestra actividad antiproliferativa contra el c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as humanas en cultivos celulares y modelos de ratones desnudos a trav\u00e9s de la v\u00eda E2F&quot; -\" \/>\n<meta property=\"og:description\" content=\"Brown, K. C., Witte, T. R., Hardman, W. E., Luo, H., Chen, Y. C., Carpenter, A. B., &#8230; &amp; Dasgupta, P. (2010).\u00a0Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS one, 5(4), e10243. ANTECEDENTES: El c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as (CPCP) [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44108\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-18T03:30:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-02T20:16:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-h3hBsOaw-pI\/X29j29xR8cI\/AAAAAAAAfzA\/DhylK3UoTnwuHPrQJyNlFPe-3_OAcxO1QCLcBGAsYHQ\/s0\/PLOS_ONE.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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contra el c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as humanas en cultivos celulares y modelos de ratones desnudos a trav\u00e9s de la v\u00eda E2F\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=44108","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La capsaicina muestra actividad antiproliferativa contra el c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as humanas en cultivos celulares y modelos de ratones desnudos a trav\u00e9s de la v\u00eda E2F\" -","og_description":"Brown, K. C., Witte, T. R., Hardman, W. E., Luo, H., Chen, Y. C., Carpenter, A. B., &#8230; &amp; Dasgupta, P. (2010).\u00a0Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS one, 5(4), e10243. ANTECEDENTES: El c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as (CPCP) [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=44108","article_published_time":"2020-09-18T03:30:25+00:00","article_modified_time":"2020-10-02T20:16:02+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-h3hBsOaw-pI\/X29j29xR8cI\/AAAAAAAAfzA\/DhylK3UoTnwuHPrQJyNlFPe-3_OAcxO1QCLcBGAsYHQ\/s0\/PLOS_ONE.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44108#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44108"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa capsaicina muestra actividad 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