{"id":44175,"date":"2020-09-24T01:30:18","date_gmt":"2020-09-23T23:30:18","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44175"},"modified":"2020-10-02T21:58:15","modified_gmt":"2020-10-02T19:58:15","slug":"area-de-conocimiento-naturopatia-descriptiva-la-deteccion-de-nutrientes-por-cpt1c-controla-la-actividad-de-sac1-para-regular-el-trafico-del-receptor-ampa","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44175","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa detecci\u00f3n de nutrientes por CPT1C controla la actividad de SAC1 para regular el tr\u00e1fico del receptor AMPA\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-x-qLfKkjHMc\/X3GmsB_jQTI\/AAAAAAAAf2A\/uF_4iLzAjW0ixZTDYwEtJmu3E7NcLahyACLcBGAsYHQ\/s255\/Journal_Cell%2BBiology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-x-qLfKkjHMc\/X3GmsB_jQTI\/AAAAAAAAf2A\/uF_4iLzAjW0ixZTDYwEtJmu3E7NcLahyACLcBGAsYHQ\/s0\/Journal_Cell%2BBiology.jpg\" border=\"0\" data-original-height=\"255\" data-original-width=\"197\" \/><\/a>Casas, M., Fad\u00f3, R., Dom\u00ednguez, J. L., Roig, A., Kaku, M., Chohnan, S., &#8230; &amp; Dickson, E. J. (2020).\u00a0<a href=\"https:\/\/rupress.org\/jcb\/article\/219\/10\/e201912045\/152088\/Sensing-of-nutrients-by-CPT1C-controls-SAC1\">Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking<\/a>.\u00a0<i>Journal of Cell Biology<\/i>, 219(10).<\/p>\n<p>La carnitina palmitoiltransferasa 1C (CPT1C) es un sensor de malonil-CoA y se encuentra en el RE de las neuronas. Los receptores AMPA (AMPAR) median la neurotransmisi\u00f3n excitadora r\u00e1pida en el cerebro y juegan un papel clave en la plasticidad sin\u00e1ptica.<\/p>\n<p>En el presente estudio, demostramos en diferentes condiciones de estr\u00e9s metab\u00f3lico que modulan los niveles de malonil-CoA en neuronas corticales que CPT1C regula el tr\u00e1fico de la subunidad principal AMPAR, GluA1, a trav\u00e9s del fosfatidil-inositol-4-fosfato (PI (4) P) fosfatasa SAC1.<\/p>\n<p>En condiciones normales, CPT1C regula negativamente la actividad catal\u00edtica de SAC1, lo que permite el tr\u00e1fico eficiente de GluA1 a la membrana plasm\u00e1tica. Sin embargo, con niveles bajos de malonil-CoA, como durante la depleci\u00f3n de glucosa, se libera la inhibici\u00f3n de SAC1 dependiente de CPT1C, facilitando la translocaci\u00f3n de SAC1 a los sitios de contacto de ER-TGN para disminuir las reservas de TGN PI (4) P y desencadenar la retenci\u00f3n de GluA1 en el TGN.<\/p>\n<p>Los resultados revelan que el tr\u00e1fico de GluA1 est\u00e1 regulado por la detecci\u00f3n de malonil-CoA por CPT1C y proporcionan el primer informe de un inhibidor de SAC1. Adem\u00e1s, arrojan luz sobre c\u00f3mo los nutrientes pueden afectar la funci\u00f3n sin\u00e1ptica y la cognici\u00f3n.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Casas, M., Fad\u00f3, R., Dom\u00ednguez, J. L., Roig, A., Kaku, M., Chohnan, S., &#8230; &amp; Dickson, E. J. (2020).\u00a0Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.\u00a0Journal of Cell Biology, 219(10). La carnitina palmitoiltransferasa 1C (CPT1C) es un sensor de malonil-CoA y se encuentra en el RE de las neuronas. Los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-44175","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La detecci\u00f3n de nutrientes por CPT1C controla la actividad de SAC1 para regular el tr\u00e1fico del receptor AMPA&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44175\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La detecci\u00f3n de nutrientes por CPT1C controla la actividad de SAC1 para regular el tr\u00e1fico del receptor AMPA&quot; -\" \/>\n<meta property=\"og:description\" content=\"Casas, M., Fad\u00f3, R., Dom\u00ednguez, J. L., Roig, A., Kaku, M., Chohnan, S., &#8230; &amp; Dickson, E. J. (2020).\u00a0Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.\u00a0Journal of Cell Biology, 219(10). La carnitina palmitoiltransferasa 1C (CPT1C) es un sensor de malonil-CoA y se encuentra en el RE de las neuronas. 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