{"id":44430,"date":"2020-10-17T00:30:26","date_gmt":"2020-10-16T22:30:26","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44430"},"modified":"2020-10-18T12:18:59","modified_gmt":"2020-10-18T10:18:59","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-acido-lipoico-en-la-esclerosis-multiple-un-estudio-piloto","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44430","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00ab\u00c1cido lipoico en la esclerosis m\u00faltiple: un estudio piloto"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-RzNnIVK5Mio\/X4wSWluoluI\/AAAAAAAAgPk\/sTKcl0dGlbssvI1kNt8v6giinTFLwr05ACLcBGAsYHQ\/s308\/Multiple_Sclerosis_Journal.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-RzNnIVK5Mio\/X4wSWluoluI\/AAAAAAAAgPk\/sTKcl0dGlbssvI1kNt8v6giinTFLwr05ACLcBGAsYHQ\/s0\/Multiple_Sclerosis_Journal.png\" border=\"0\" data-original-height=\"308\" data-original-width=\"231\" \/><\/a>Yadav, V., Marracci, G., Lovera, J., Woodward, W., Bogardus, K., Marquardt, W., &amp; Bourdette, D. (2005).\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Jesus_Lovera\/publication\/7942307_Lipoic_acid_in_multiple_sclerosis_A_pilot_study\/links\/00b7d52f4260524ae0000000.pdf\">Lipoic acid in multiple sclerosis: a pilot study<\/a>.\u00a0<i>Multiple Sclerosis Journal<\/i>, 11(2), 159-165.<\/p>\n<p>FONDO: El \u00e1cido lipoico (LA) es un antioxidante que suprime y trata un modelo animal de esclerosis m\u00faltiple (EM), encefalomielitis autoinmune experimental.<\/p>\n<p>OBJETIVO: El prop\u00f3sito de este estudio fue determinar la farmacocin\u00e9tica (PK), la tolerabilidad y los efectos sobre la metaloproteinasa de matriz-9 (MMP-9) y la mol\u00e9cula de adhesi\u00f3n intercelular soluble-1 (sICAMP-1) de LA oral en pacientes con EM.<\/p>\n<p>METODOLOG\u00cdA: Treinta y siete sujetos con EM fueron asignados aleatoriamente a uno de cuatro grupos: placebo, LA 600 mg dos veces al d\u00eda, LA 1200 mg una vez al d\u00eda y LA 1200 mg dos veces al d\u00eda. Los sujetos tomaron c\u00e1psulas de estudio durante 14 d\u00edas.<\/p>\n<p>RESULTADOS: Encontramos que los sujetos que tomaban 1200 mg de LA ten\u00edan niveles m\u00e1ximos de LA en suero sustancialmente m\u00e1s altos que los que tomaban 600 mg y que los niveles m\u00e1ximos variaban considerablemente entre los sujetos. Tambi\u00e9n encontramos una correlaci\u00f3n negativa significativa entre los niveles m\u00e1ximos de LA s\u00e9rica y los cambios medios en los niveles s\u00e9ricos de MMP-9 (T = -0,263, P = 0,04). Hubo una relaci\u00f3n dosis-respuesta significativa entre LA y el cambio medio en los niveles s\u00e9ricos de sICAM-1 (P = 0,03).<\/p>\n<p>CONCLUSION: Llegamos a la conclusi\u00f3n de que el LA oral es generalmente bien tolerado y parece capaz de reducir los niveles s\u00e9ricos de MMP-9 y sICAM-1. LA puede resultar \u00fatil en el tratamiento de la EM al inhibir la actividad de MMP-9 e interferir con la migraci\u00f3n de c\u00e9lulas T al SNC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yadav, V., Marracci, G., Lovera, J., Woodward, W., Bogardus, K., Marquardt, W., &amp; Bourdette, D. (2005).\u00a0Lipoic acid in multiple sclerosis: a pilot study.\u00a0Multiple Sclerosis Journal, 11(2), 159-165. FONDO: El \u00e1cido lipoico (LA) es un antioxidante que suprime y trata un modelo animal de esclerosis m\u00faltiple (EM), encefalomielitis autoinmune experimental. OBJETIVO: El prop\u00f3sito de este estudio [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44430","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;\u00c1cido lipoico en la esclerosis m\u00faltiple: un estudio piloto -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44430\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;\u00c1cido lipoico en la esclerosis m\u00faltiple: un estudio piloto -\" \/>\n<meta property=\"og:description\" content=\"Yadav, V., Marracci, G., Lovera, J., Woodward, W., Bogardus, K., Marquardt, W., &amp; Bourdette, D. (2005).\u00a0Lipoic acid in multiple sclerosis: a pilot study.\u00a0Multiple Sclerosis Journal, 11(2), 159-165. FONDO: El \u00e1cido lipoico (LA) es un antioxidante que suprime y trata un modelo animal de esclerosis m\u00faltiple (EM), encefalomielitis autoinmune experimental. OBJETIVO: El prop\u00f3sito de este estudio [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44430\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-16T22:30:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-10-18T10:18:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-RzNnIVK5Mio\/X4wSWluoluI\/AAAAAAAAgPk\/sTKcl0dGlbssvI1kNt8v6giinTFLwr05ACLcBGAsYHQ\/s0\/Multiple_Sclerosis_Journal.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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