{"id":44442,"date":"2020-10-17T04:30:49","date_gmt":"2020-10-17T02:30:49","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44442"},"modified":"2020-10-20T12:43:20","modified_gmt":"2020-10-20T10:43:20","slug":"44442","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44442","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abAcciones beneficiosas del \u00e1cido olean\u00f3lico en un modelo experimental de esclerosis m\u00faltiple: un papel terap\u00e9utico potencial\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-hBDqA-qcmtU\/X4ysdDuVC3I\/AAAAAAAAgQM\/6XVrChKs384iPM8Ay6Nbuvz6NDvY5UCegCLcBGAsYHQ\/s259\/Biochemical_pharmacology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-hBDqA-qcmtU\/X4ysdDuVC3I\/AAAAAAAAgQM\/6XVrChKs384iPM8Ay6Nbuvz6NDvY5UCegCLcBGAsYHQ\/s0\/Biochemical_pharmacology.jpg\" border=\"0\" data-original-height=\"259\" data-original-width=\"194\" \/><\/a>Mart\u00edn, R., Carvalho-Tavares, J., Hern\u00e1ndez, M., Arnes, M., Ruiz-Gutierrez, V., &amp; Nieto, M. L. (2010).\u00a0<a href=\"https:\/\/hal.archives-ouvertes.fr\/hal-00535822\/document\">Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role<\/a>.\u00a0<i>Biochemical pharmacology<\/i>, 79(2), 198-208.<\/p>\n<p>La esclerosis m\u00faltiple (EM) es una enfermedad inflamatoria autoinmune cr\u00f3nica para la que no existen terapias sin efectos secundarios no deseados. Por tanto, el establecimiento de tratamientos menos t\u00f3xicos es un desaf\u00edo continuo. Hoy en d\u00eda, la investigaci\u00f3n sobre plantas medicinales ha estado atrayendo mucha atenci\u00f3n, ya que el cribado de sus principios activos podr\u00eda resultar \u00fatil en la identificaci\u00f3n de mol\u00e9culas farmac\u00e9uticas seguras e innovadoras.<\/p>\n<p>En este estudio investigamos el efecto terap\u00e9utico del \u00e1cido olean\u00f3lico (AO), un triterpeno derivado de plantas con potentes actividades antiinflamatorias e inmunomoduladoras, cuyas acciones sobre las enfermedades del SNC est\u00e1n lejos de estar completamente caracterizadas. Nos centramos en el posible efecto terap\u00e9utico del \u00e1cido olean\u00f3lico (OA) en un modelo experimental aceptado de EM, la encefalomielitis autoinmune experimental (EAE).<\/p>\n<p>Hemos encontrado que el tratamiento de OA, antes o al comienzo de la EAE, mejora los signos neurol\u00f3gicos de los ratones EAE. Estos efectos beneficiosos de la OA parecen estar asociados con una reducci\u00f3n de la fuga de la barrera hematoencef\u00e1lica y una menor infiltraci\u00f3n de c\u00e9lulas inflamatorias dentro del SNC, as\u00ed como con su papel modulador en la polarizaci\u00f3n Th1 \/ Th2: inhibici\u00f3n de citocinas y quimiocinas proinflamatorias y estimulaci\u00f3n de antiinflamatorios. Adem\u00e1s, los animales EAE que fueron tratados con OA ten\u00edan niveles m\u00e1s bajos de anticuerpos anti-MOG que los ratones EAE no tratados. inhibici\u00f3n de citocinas y quimiocinas proinflamatorias, y estimulaci\u00f3n de antiinflamatorias.<\/p>\n<p>Nuestros hallazgos muestran que la administraci\u00f3n de la OA triterpenoide natural reduce y limita la gravedad y el desarrollo de EAE. Por lo tanto, la terapia con OA podr\u00eda ser de inter\u00e9s cl\u00ednico para la EM humana y otras enfermedades inflamatorias mediadas por c\u00e9lulas Th1.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mart\u00edn, R., Carvalho-Tavares, J., Hern\u00e1ndez, M., Arnes, M., Ruiz-Gutierrez, V., &amp; Nieto, M. L. (2010).\u00a0Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role.\u00a0Biochemical pharmacology, 79(2), 198-208. La esclerosis m\u00faltiple (EM) es una enfermedad inflamatoria autoinmune cr\u00f3nica para la que no existen terapias sin efectos secundarios no deseados. Por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44442","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Acciones beneficiosas del \u00e1cido olean\u00f3lico en un modelo experimental de esclerosis m\u00faltiple: un papel terap\u00e9utico potencial&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44442\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Acciones beneficiosas del \u00e1cido olean\u00f3lico en un modelo experimental de esclerosis m\u00faltiple: un papel terap\u00e9utico potencial&quot; -\" \/>\n<meta property=\"og:description\" content=\"Mart\u00edn, R., Carvalho-Tavares, J., Hern\u00e1ndez, M., Arnes, M., Ruiz-Gutierrez, V., &amp; Nieto, M. L. (2010).\u00a0Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: a potential therapeutic role.\u00a0Biochemical pharmacology, 79(2), 198-208. La esclerosis m\u00faltiple (EM) es una enfermedad inflamatoria autoinmune cr\u00f3nica para la que no existen terapias sin efectos secundarios no deseados. 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