{"id":44632,"date":"2020-11-02T06:30:42","date_gmt":"2020-11-02T05:30:42","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44632"},"modified":"2020-11-04T14:17:09","modified_gmt":"2020-11-04T13:17:09","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-flavonoides-compuestos-biologicamente-activos-potentes-y-versatiles-que-interactuan-con-los-citocromos-p450","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44632","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-LVzY0T2hSAQ\/X6Kivg93NkI\/AAAAAAAAggI\/q6CYmZ3q86EO6xMV87bvF96V_Y-rYRqNgCLcBGAsYHQ\/s768\/Chemico_Biological%2BInteractions.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-LVzY0T2hSAQ\/X6Kivg93NkI\/AAAAAAAAggI\/q6CYmZ3q86EO6xMV87bvF96V_Y-rYRqNgCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg\" height=\"320\" border=\"0\" data-original-height=\"768\" data-original-width=\"576\" \/><\/a>Hodek, P., Trefil, P., &amp; Stiborov\u00e1, M. (2002). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S000927970100285X\">Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450<\/a>.\u00a0<i>Chemico-biological interactions<\/i>, 139(1), 1-21.<\/p>\n<p>Los flavonoides representan un grupo de fitoqu\u00edmicos que exhiben una amplia gama de actividades biol\u00f3gicas que surgen principalmente de sus propiedades antioxidantes y su capacidad para modular varias enzimas o receptores celulares.<\/p>\n<p>Se ha reconocido que los flavonoides ejercen actividad antibacteriana y antiviral, efectos antiinflamatorios, antiangi\u00f3nicos, analg\u00e9sicos, antial\u00e9rgicos, hepatoprotectores, citost\u00e1ticos, apopt\u00f3ticos, estrog\u00e9nicos y antiestrog\u00e9nicos. Sin embargo, no todos los flavonoides y sus acciones son necesariamente beneficiosos. Algunos flavonoides tienen efectos mutag\u00e9nicos y \/ o prooxidantes y tambi\u00e9n pueden interferir con las v\u00edas bioqu\u00edmicas esenciales.<\/p>\n<p>Entre las prote\u00ednas que interact\u00faan con los flavonoides, los citocromos P450 (CYP), las monooxigenasas que metabolizan xenobi\u00f3ticos (por ejemplo, f\u00e1rmacos, carcin\u00f3genos) y sustratos end\u00f3genos (por ejemplo, esteroides), juegan un papel destacado. Los compuestos flavonoides influyen en estas enzimas de varias formas: los flavonoides inducen la expresi\u00f3n de varios CYP y modulan (inhiben o estimulan) su actividad metab\u00f3lica. Adem\u00e1s, algunos CYP participan en el metabolismo de los flavonoides.<\/p>\n<p>Los flavonoides mejoran la activaci\u00f3n de carcin\u00f3genos y \/ o influyen en el metabolismo de f\u00e1rmacos mediante la inducci\u00f3n de CYP espec\u00edficos. Por otro lado, la inhibici\u00f3n de los CYP implicados en la activaci\u00f3n de carcin\u00f3genos y la eliminaci\u00f3n de especies reactivas formadas a partir de carcin\u00f3genos por reacciones mediadas por CYP pueden ser propiedades beneficiosas de varios flavonoides. Los flavonoides muestran una actividad estrog\u00e9nica o antiestrog\u00e9nica debido a la similitud estructural con el esqueleto de estr\u00f3genos. Al imitar los estr\u00f3genos naturales, se unen al receptor de estr\u00f3genos y modulan su actividad. Tambi\u00e9n bloquean CYP19, una enzima crucial involucrada en la bios\u00edntesis de estr\u00f3genos.<\/p>\n<p>Los flavonoides en la dieta humana pueden reducir el riesgo de varios c\u00e1nceres, especialmente c\u00e1nceres de pr\u00f3stata y mama dependientes de hormonas, adem\u00e1s de prevenir los s\u00edntomas de la menopausia. Por estas razones, la relaci\u00f3n estructura-funci\u00f3n de los flavonoides se estudia extensamente para proporcionar una inspiraci\u00f3n para un dise\u00f1o racional de f\u00e1rmacos y \/ o agentes quimiopreventivos de futuros f\u00e1rmacos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hodek, P., Trefil, P., &amp; Stiborov\u00e1, M. (2002). Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.\u00a0Chemico-biological interactions, 139(1), 1-21. Los flavonoides representan un grupo de fitoqu\u00edmicos que exhiben una amplia gama de actividades biol\u00f3gicas que surgen principalmente de sus propiedades antioxidantes y su capacidad para modular varias enzimas o receptores celulares. Se ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44632","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Flavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44632\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Flavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450&quot; -\" \/>\n<meta property=\"og:description\" content=\"Hodek, P., Trefil, P., &amp; Stiborov\u00e1, M. (2002). Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.\u00a0Chemico-biological interactions, 139(1), 1-21. Los flavonoides representan un grupo de fitoqu\u00edmicos que exhiben una amplia gama de actividades biol\u00f3gicas que surgen principalmente de sus propiedades antioxidantes y su capacidad para modular varias enzimas o receptores celulares. Se ha [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44632\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-02T05:30:42+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-04T13:17:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-LVzY0T2hSAQ\/X6Kivg93NkI\/AAAAAAAAggI\/q6CYmZ3q86EO6xMV87bvF96V_Y-rYRqNgCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44632#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44632\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\u00bb\",\"datePublished\":\"2020-11-02T05:30:42+00:00\",\"dateModified\":\"2020-11-04T13:17:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44632\"},\"wordCount\":407,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=44632#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44632\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44632\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"Flavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-11-02T05:30:42+00:00\",\"dateModified\":\"2020-11-04T13:17:09+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44632#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=44632\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=44632#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Flavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=44632","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Flavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\" -","og_description":"Hodek, P., Trefil, P., &amp; Stiborov\u00e1, M. (2002). Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.\u00a0Chemico-biological interactions, 139(1), 1-21. Los flavonoides representan un grupo de fitoqu\u00edmicos que exhiben una amplia gama de actividades biol\u00f3gicas que surgen principalmente de sus propiedades antioxidantes y su capacidad para modular varias enzimas o receptores celulares. Se ha [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=44632","article_published_time":"2020-11-02T05:30:42+00:00","article_modified_time":"2020-11-04T13:17:09+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-LVzY0T2hSAQ\/X6Kivg93NkI\/AAAAAAAAggI\/q6CYmZ3q86EO6xMV87bvF96V_Y-rYRqNgCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44632#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44632"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\u00bb","datePublished":"2020-11-02T05:30:42+00:00","dateModified":"2020-11-04T13:17:09+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44632"},"wordCount":407,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=44632#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44632","url":"https:\/\/rina.naturopatiadigital.eu\/?p=44632","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Flavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-11-02T05:30:42+00:00","dateModified":"2020-11-04T13:17:09+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44632#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=44632"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=44632#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides: compuestos biol\u00f3gicamente activos potentes y vers\u00e1tiles que interact\u00faan con los citocromos P450\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=44632"}],"version-history":[{"count":2,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44632\/revisions"}],"predecessor-version":[{"id":44634,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/44632\/revisions\/44634"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=44632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=44632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=44632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}