{"id":44656,"date":"2020-11-04T01:30:44","date_gmt":"2020-11-04T00:30:44","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44656"},"modified":"2020-11-07T15:22:58","modified_gmt":"2020-11-07T14:22:58","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-efecto-de-la-cordicepina-sobre-la-produccion-de-interleucina-10-de-celulas-mononucleares-de-sangre-periferica-humana","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44656","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEfecto de la cordicepina sobre la producci\u00f3n de interleucina-10 de c\u00e9lulas mononucleares de sangre perif\u00e9rica humana\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-k_4MRTeQTYY\/X6adHMIv5_I\/AAAAAAAAgio\/IBwkSHzYrUc4OCl5z_BDuTo9yoin295oACLcBGAsYHQ\/s768\/European_Journal_Pharmacology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-k_4MRTeQTYY\/X6adHMIv5_I\/AAAAAAAAgio\/IBwkSHzYrUc4OCl5z_BDuTo9yoin295oACLcBGAsYHQ\/s320\/European_Journal_Pharmacology.jpg\" height=\"320\" border=\"0\" data-original-height=\"768\" data-original-width=\"576\" \/><\/a>Zhou, X., Meyer, C. U., Schmidtke, P., &amp; Zepp, F. (2002).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0014299902023592\">Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells<\/a>.\u00a0<i>European journal of pharmacology<\/i>, 453(2-3), 309-317.<\/p>\n<p>FONDO: Las opciones terap\u00e9uticas para controlar las enfermedades autoinmunes a\u00fan son muy limitadas. Se ha informado que la interleucina-10 es un enfoque prometedor para la intervenci\u00f3n terap\u00e9utica.<\/p>\n<p>OBJETIVO: En la b\u00fasqueda de un f\u00e1rmaco que produzca una regulaci\u00f3n positiva selectiva de la interleucina-10, investigamos los efectos inmunorreguladores de la cordicepina.<\/p>\n<p>METODOLOGIA: Hemos medido la secreci\u00f3n de interleucina-10 e interleucina-2 de c\u00e9lulas mononucleares de sangre perif\u00e9rica humana que se incubaron con cordicepina y hemos evaluado la influencia de la cordicepina en la expresi\u00f3n de ARNm de interleucina-10, la respuesta proliferativa y la expresi\u00f3n de marcadores de superficie en los linfocitos T. Adem\u00e1s, se evaluaron los subconjuntos de c\u00e9lulas secretoras de interleucina-10, la influencia del anticuerpo neutralizante anti-interleucina-10 y la citotoxicidad de la cordicepina.<\/p>\n<p>RESULTADOS: Nuestros resultados sugieren que la cordicepina tiene un efecto regulador positivo significativo sobre la producci\u00f3n de interleucina-10 y la expresi\u00f3n de ARNm de interleucina-10. C\u00e9lulas productoras de interleucina-10 incluidas en c\u00e9lulas CD4 +, CD8 +, CD19 +, CD56 + y CD14 +. Al mismo tiempo, la cordicepina inhibi\u00f3 la producci\u00f3n de interleucina-2 inducida por fitohemaglutinina y la proliferaci\u00f3n de c\u00e9lulas mononucleares de sangre perif\u00e9rica. Una activaci\u00f3n restringida de linfocitos T tambi\u00e9n se reflej\u00f3 en una expresi\u00f3n reducida de los marcadores de superficie CD25, CD45RO, CD54, CD71 y HLA DR. El anticuerpo neutralizante anti-interleucina-10 no pudo bloquear completamente el efecto supresor de la cordicepina sobre la producci\u00f3n de interleucina-2. La cordicepina en la concentraci\u00f3n efectiva present\u00f3 una ligera citotoxicidad pero no aument\u00f3 la apoptosis.<\/p>\n<p>CONCLUSION: Estos resultados indican que la cordicepina ejerce efectos inmunorreguladores. La investigaci\u00f3n adicional al respecto puede proporcionar un enfoque para el desarrollo de nuevos f\u00e1rmacos inmunomoduladores que alteren directamente la secreci\u00f3n de citocinas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhou, X., Meyer, C. U., Schmidtke, P., &amp; Zepp, F. (2002).\u00a0Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells.\u00a0European journal of pharmacology, 453(2-3), 309-317. FONDO: Las opciones terap\u00e9uticas para controlar las enfermedades autoinmunes a\u00fan son muy limitadas. Se ha informado que la interleucina-10 es un enfoque prometedor para la intervenci\u00f3n terap\u00e9utica. OBJETIVO: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44656","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto de la cordicepina sobre la producci\u00f3n de interleucina-10 de c\u00e9lulas mononucleares de sangre perif\u00e9rica humana&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44656\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Efecto de la cordicepina sobre la producci\u00f3n de interleucina-10 de c\u00e9lulas mononucleares de sangre perif\u00e9rica humana&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zhou, X., Meyer, C. U., Schmidtke, P., &amp; Zepp, F. (2002).\u00a0Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells.\u00a0European journal of pharmacology, 453(2-3), 309-317. FONDO: Las opciones terap\u00e9uticas para controlar las enfermedades autoinmunes a\u00fan son muy limitadas. Se ha informado que la interleucina-10 es un enfoque prometedor para la intervenci\u00f3n terap\u00e9utica. OBJETIVO: [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44656\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-04T00:30:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-07T14:22:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-k_4MRTeQTYY\/X6adHMIv5_I\/AAAAAAAAgio\/IBwkSHzYrUc4OCl5z_BDuTo9yoin295oACLcBGAsYHQ\/s320\/European_Journal_Pharmacology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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