{"id":44662,"date":"2020-11-04T04:30:08","date_gmt":"2020-11-04T03:30:08","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44662"},"modified":"2020-11-07T16:27:28","modified_gmt":"2020-11-07T15:27:28","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-andrografolido-un-remedio-herbal-inhibe-la-expresion-de-interleucina-6-y-suprime-el-crecimiento-de-celulas-cancerosas-de-p","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44662","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl andrograf\u00f3lido, un remedio herbal, inhibe la expresi\u00f3n de interleucina-6 y suprime el crecimiento de c\u00e9lulas cancerosas de pr\u00f3stata\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-KoRsvp1fodQ\/X6a66TAzZVI\/AAAAAAAAgjI\/g_kC6Ox9Q0MfrmeQdxXw62cJ0vGCM5YDgCLcBGAsYHQ\/s256\/Genes_cancer.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-KoRsvp1fodQ\/X6a66TAzZVI\/AAAAAAAAgjI\/g_kC6Ox9Q0MfrmeQdxXw62cJ0vGCM5YDgCLcBGAsYHQ\/s0\/Genes_cancer.jpg\" border=\"0\" data-original-height=\"256\" data-original-width=\"197\" \/><\/a>Chun, J. Y., Tummala, R., Nadiminty, N., Lou, W., Liu, C., Yang, J., &#8230; &amp; Gao, A. C. (2010).\u00a0<a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/1947601910383416\">Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.\u00a0<\/a><i>Genes &amp; cancer<\/i>, 1(8), 868-876.<\/p>\n<p>La interleucina-6 elevada (IL-6), un mediador importante de la respuesta inflamatoria, se ha implicado en la activaci\u00f3n, el crecimiento y la diferenciaci\u00f3n celular del receptor de andr\u00f3genos (AR), desempe\u00f1a un papel importante en el desarrollo y la progresi\u00f3n del c\u00e1ncer de pr\u00f3stata y es un potencial objetivo en la terapia del c\u00e1ncer.<\/p>\n<p>Mediante el cribado de f\u00e1rmacos con c\u00e9lulas de c\u00e1ncer de pr\u00f3stata humano que expresan el bucle autocrino de IL-6, encontramos que el andrograf\u00f3lido, una lactona diterpenoide aislada de una planta medicinal tradicional china e india, Andrographis paniculata, podr\u00eda inhibir la expresi\u00f3n de IL-6 y suprimir las se\u00f1ales mediadas por IL-6. El andrograf\u00f3lido inhibe la expresi\u00f3n de IL-6 tanto a niveles de ARNm como de prote\u00edna de una manera dependiente de la dosis.<\/p>\n<p>Andrographolide suprime la se\u00f1alizaci\u00f3n celular inducida por bucle autocrino y paracrino de IL-6, incluida la fosforilaci\u00f3n de Stat3 y Erk. Adem\u00e1s, el andrograf\u00f3lido inhibe la viabilidad celular e induce la muerte celular apopt\u00f3tica en c\u00e9lulas de c\u00e1ncer de pr\u00f3stata humano estimuladas con andr\u00f3genos y resistentes a la castraci\u00f3n sin causar una toxicidad significativa a las c\u00e9lulas epiteliales de pr\u00f3stata inmortalizadas normales. Adem\u00e1s, el tratamiento con andrograf\u00f3lido en ratones que portan tumores de pr\u00f3stata humanos DU145 resistentes a la castraci\u00f3n que expresan el bucle autocrino de IL-6 constitutivo suprime significativamente el crecimiento tumoral.<\/p>\n<p>Tomados en conjunto, estos resultados demuestran que el andrograf\u00f3lido podr\u00eda desarrollarse como un agente terap\u00e9utico para tratar el c\u00e1ncer de pr\u00f3stata tanto estimulado por andr\u00f3genos como resistente a la castraci\u00f3n, posiblemente al suprimir la expresi\u00f3n de IL-6 y la se\u00f1alizaci\u00f3n inducida por IL-6.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chun, J. Y., Tummala, R., Nadiminty, N., Lou, W., Liu, C., Yang, J., &#8230; &amp; Gao, A. C. (2010).\u00a0Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.\u00a0Genes &amp; cancer, 1(8), 868-876. La interleucina-6 elevada (IL-6), un mediador importante de la respuesta inflamatoria, se ha implicado en la activaci\u00f3n, el crecimiento y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44662","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El andrograf\u00f3lido, un remedio herbal, inhibe la expresi\u00f3n de interleucina-6 y suprime el crecimiento de c\u00e9lulas cancerosas de pr\u00f3stata&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44662\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El andrograf\u00f3lido, un remedio herbal, inhibe la expresi\u00f3n de interleucina-6 y suprime el crecimiento de c\u00e9lulas cancerosas de pr\u00f3stata&quot; -\" \/>\n<meta property=\"og:description\" content=\"Chun, J. Y., Tummala, R., Nadiminty, N., Lou, W., Liu, C., Yang, J., &#8230; &amp; Gao, A. C. (2010).\u00a0Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth.\u00a0Genes &amp; cancer, 1(8), 868-876. 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