{"id":44766,"date":"2020-11-11T01:30:49","date_gmt":"2020-11-11T00:30:49","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44766"},"modified":"2020-11-12T20:17:19","modified_gmt":"2020-11-12T19:17:19","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-eupatilina-inhibe-el-crecimiento-del-cancer-de-rinon-al-regular-negativamente-el-microarn-21-mediante-la-activacion-de-yap1","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44766","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa eupatilina inhibe el crecimiento del c\u00e1ncer de ri\u00f1\u00f3n al regular negativamente el microARN-21 mediante la activaci\u00f3n de YAP1\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-T9x7opKZiB4\/X62JXb4vW1I\/AAAAAAAAgqU\/g-POC6GIzzEPAIaT6EH5ays6uXQo5rM6wCLcBGAsYHQ\/s278\/BioMed_Research_International.JPG\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-T9x7opKZiB4\/X62JXb4vW1I\/AAAAAAAAgqU\/g-POC6GIzzEPAIaT6EH5ays6uXQo5rM6wCLcBGAsYHQ\/s0\/BioMed_Research_International.JPG\" border=\"0\" data-original-height=\"278\" data-original-width=\"205\" \/><\/a>Zhong, W., Wu, Z., Chen, N., Zhong, K., Lin, Y., Jiang, H., &#8230; &amp; Liu, S. (2019).\u00a0<a href=\"https:\/\/www.hindawi.com\/journals\/bmri\/2019\/5016483\/\">Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1<\/a>.\u00a0<i>BioMed Research International<\/i>, 2019.<\/p>\n<p>El carcinoma de c\u00e9lulas renales (CCR) es el segundo tumor urinario humano m\u00e1s com\u00fan. Eupatilina es el principal ingrediente activo de la medicina tradicional china Artemisia asiatica. El efecto de Eupatilin sobre RCC y el mecanismo subyacente siguen siendo desconocidos.<\/p>\n<p>Aqu\u00ed, investigamos los efectos y mecanismos anticancer\u00edgenos de Eupatilina en RCC in vivo e in vitro, sentando una base experimental para la aplicaci\u00f3n cl\u00ednica de Eupatilin en el tratamiento de RCC. Los resultados mostraron que Eupatilina inhibi\u00f3 significativamente la viabilidad y migraci\u00f3n de las c\u00e9lulas 786-O y promovi\u00f3 la apoptosis.<\/p>\n<p>Eupatilin inhibi\u00f3 la expresi\u00f3n de miR-21 en c\u00e9lulas 786-O y la sobreexpresi\u00f3n de miR-21 suprimi\u00f3 el efecto de Eupatilin sobre la viabilidad, apoptosis y migraci\u00f3n en c\u00e9lulas 786-O. Eupatilin inhibi\u00f3 el crecimiento de tumores renales en ratones desnudos regulando negativamente miR-21. YAP1, que se identific\u00f3 como un objetivo de miR-21, mostr\u00f3 una expresi\u00f3n significativamente menor en los tejidos de RCC que en los tejidos sanos. miR-21 inhibi\u00f3 significativamente la expresi\u00f3n de la prote\u00edna YAP1 en c\u00e9lulas 786-O y tejidos tumorales aislados de ratones desnudos, y YAP1 atenu\u00f3 el efecto de miR-21 sobre la viabilidad, apoptosis y migraci\u00f3n de c\u00e9lulas 786-O.<\/p>\n<p>CONCLUSION: En conclusi\u00f3n, Eupatilina inhibi\u00f3 la expresi\u00f3n de miR-21, que medi\u00f3 los efectos proapopt\u00f3ticos y antimigratorios de Eupatilina al suprimir YAP1 en las c\u00e9lulas de c\u00e1ncer renal. Estos resultados sugirieron que Eupatilina podr\u00eda ser un agente potente para el tratamiento del CCR.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhong, W., Wu, Z., Chen, N., Zhong, K., Lin, Y., Jiang, H., &#8230; &amp; Liu, S. (2019).\u00a0Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1.\u00a0BioMed Research International, 2019. El carcinoma de c\u00e9lulas renales (CCR) es el segundo tumor urinario humano m\u00e1s com\u00fan. Eupatilina es el principal ingrediente activo de la medicina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44766","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La eupatilina inhibe el crecimiento del c\u00e1ncer de ri\u00f1\u00f3n al regular negativamente el microARN-21 mediante la activaci\u00f3n de YAP1&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44766\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La eupatilina inhibe el crecimiento del c\u00e1ncer de ri\u00f1\u00f3n al regular negativamente el microARN-21 mediante la activaci\u00f3n de YAP1&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zhong, W., Wu, Z., Chen, N., Zhong, K., Lin, Y., Jiang, H., &#8230; &amp; Liu, S. (2019).\u00a0Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1.\u00a0BioMed Research International, 2019. El carcinoma de c\u00e9lulas renales (CCR) es el segundo tumor urinario humano m\u00e1s com\u00fan. 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