{"id":44933,"date":"2020-11-25T05:30:32","date_gmt":"2020-11-25T04:30:32","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44933"},"modified":"2020-11-26T21:44:33","modified_gmt":"2020-11-26T20:44:33","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-efecto-de-la-espermidina-sobre-el-rendimiento-de-la-memoria-en-adultos-mayores-con-riesgo-de-demencia-un-ensayo-controlado","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44933","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl efecto de la espermidina sobre el rendimiento de la memoria en adultos mayores con riesgo de demencia: un ensayo controlado aleatorio\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-7KJWsHESFrk\/X8ASO55mdrI\/AAAAAAAAg3U\/_QaT9wMEDS0MGNzPQd4tZF9gtrjktltIwCLcBGAsYHQ\/s768\/Cortex.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-7KJWsHESFrk\/X8ASO55mdrI\/AAAAAAAAg3U\/_QaT9wMEDS0MGNzPQd4tZF9gtrjktltIwCLcBGAsYHQ\/s320\/Cortex.jpg\" height=\"320\" border=\"0\" data-original-height=\"768\" data-original-width=\"576\" \/><\/a>Wirth, M., Benson, G., Schwarz, C., K\u00f6be, T., Grittner, U., Schmitz, D., &#8230; &amp; Fl\u00f6el, A. (2018). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0010945218303137\">The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial<\/a>.\u00a0<i>Cortex<\/i>, 109, 181-188.<\/p>\n<p>INTRODUCCI\u00d3N: La intervenci\u00f3n nutricional con la poliamina espermidina natural, un agente potenciador de la autofagia, puede prevenir la p\u00e9rdida de memoria en organismos modelo envejecidos. Este es el primer estudio en humanos que eval\u00faa el impacto de la suplementaci\u00f3n con espermidina en el rendimiento de la memoria en adultos mayores con riesgo de desarrollar la enfermedad de Alzheimer.<\/p>\n<p>METODOS: Se incluy\u00f3 a participantes cognitivamente intactos con deterioro cognitivo subjetivo (n = 30, 60-80 a\u00f1os de edad) en este ensayo piloto de fase IIa doble ciego, aleatorizado, controlado con placebo y de tres meses con un suplemento de extracto vegetal rico en espermidina. Los efectos de la intervenci\u00f3n se evaluaron mediante la tarea de similitud mnemot\u00e9cnica conductual, medida en las visitas iniciales y posteriores a la intervenci\u00f3n. El an\u00e1lisis de datos se centr\u00f3 en informar e interpretar la efectividad seg\u00fan los tama\u00f1os del efecto.<\/p>\n<p>RESULTADOS: El rendimiento de la memoria mejor\u00f3 moderadamente en el grupo de espermidina en comparaci\u00f3n con el placebo al final de la intervenci\u00f3n [media de contraste = .17, intervalo de confianza (IC) del 95%: \u2212.01, .35, d de Cohen = .77, IC del 95%: 0 , 1,53]. La capacidad de discriminaci\u00f3n mnem\u00f3nica mejor\u00f3 en el grupo tratado con espermidina con un tama\u00f1o de efecto medio (diferencia media = \u2212.11, IC del 95%: \u2212.19, \u2212.03, d de Cohen = .79, IC del 95%: .01, 1.55) . No se encontr\u00f3 un efecto similar en el grupo tratado con placebo (diferencia media = .07, IC del 95%: \u2212.13, .27, d de Cohen = \u2212.20, IC del 95%: \u2212.94, .54).<\/p>\n<p>DISCUSION: En este ensayo piloto, la espermidina nutricional se asoci\u00f3 con un impacto positivo en el rendimiento de la memoria en adultos mayores con deterioro cognitivo. El efecto beneficioso podr\u00eda estar mediado por la estimulaci\u00f3n de acciones neuromoduladoras en el sistema de memoria. Un ensayo controlado aleatorizado de Fase IIb de seguimiento ayudar\u00e1 a validar el potencial terap\u00e9utico de la suplementaci\u00f3n con espermidina y delinear los posibles mecanismos de acci\u00f3n neurofisiol\u00f3gicos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wirth, M., Benson, G., Schwarz, C., K\u00f6be, T., Grittner, U., Schmitz, D., &#8230; &amp; Fl\u00f6el, A. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.\u00a0Cortex, 109, 181-188. INTRODUCCI\u00d3N: La intervenci\u00f3n nutricional con la poliamina espermidina natural, un agente potenciador de la autofagia, puede prevenir la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44933","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El efecto de la espermidina sobre el rendimiento de la memoria en adultos mayores con riesgo de demencia: un ensayo controlado aleatorio&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44933\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El efecto de la espermidina sobre el rendimiento de la memoria en adultos mayores con riesgo de demencia: un ensayo controlado aleatorio&quot; -\" \/>\n<meta property=\"og:description\" content=\"Wirth, M., Benson, G., Schwarz, C., K\u00f6be, T., Grittner, U., Schmitz, D., &#8230; &amp; Fl\u00f6el, A. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.\u00a0Cortex, 109, 181-188. 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