{"id":44987,"date":"2020-11-30T00:30:38","date_gmt":"2020-11-29T23:30:38","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=44987"},"modified":"2020-11-30T14:39:42","modified_gmt":"2020-11-30T13:39:42","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-suprime-la-proliferacion-del-cancer-de-colon-al-inhibir-las-vias-wnt-%ce%b2-catenina-a-traves-de-mir-130a","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=44987","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina suprime la proliferaci\u00f3n del c\u00e1ncer de colon al inhibir las v\u00edas Wnt \/ \u03b2-catenina a trav\u00e9s de miR-130a\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-pnu-blGLBu0\/X8T1kN9Vg-I\/AAAAAAAAg8Q\/0ECxGEgz8fs6dOlSd8thIh51Xi3qpVuRACLcBGAsYHQ\/s940\/frontiers_pharmacology2.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-pnu-blGLBu0\/X8T1kN9Vg-I\/AAAAAAAAg8Q\/0ECxGEgz8fs6dOlSd8thIh51Xi3qpVuRACLcBGAsYHQ\/s320\/frontiers_pharmacology2.png\" width=\"320\" border=\"0\" data-original-height=\"258\" data-original-width=\"940\" \/><\/a>Dou, H., Shen, R., Tao, J., Huang, L., Shi, H., Chen, H., &#8230; &amp; Wang, T. (2017). <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2017.00877\/full\">Curcumin suppresses the colon cancer proliferation by inhibiting Wnt\/\u03b2-catenin pathways via miR-130a.<\/a>\u00a0<i>Frontiers in pharmacology<\/i>, 8, 877.<\/p>\n<p>FONDO: La curcumina exhibe efectos antitumorales en varios c\u00e1nceres, incluido el carcinoma colorrectal (CCR), pero los mecanismos detallados a\u00fan no est\u00e1n claros.<\/p>\n<p>OBJETIVO: Aqu\u00ed estudiamos los mecanismos subyacentes al efecto antitumoral de la curcumina en las c\u00e9lulas de c\u00e1ncer de colon.<\/p>\n<p>METODO: Se inyectaron c\u00e9lulas SW480 en ratones para establecer el modelo de tumor de xenoinjerto, seguido de la evaluaci\u00f3n de la tasa de supervivencia con el tratamiento de curcumina. Se midieron los niveles de expresi\u00f3n de \u03b2-catenina, Axina y TCF4 en las c\u00e9lulas SW480 en ausencia o presencia de curcumina. Adem\u00e1s, los miARN relacionados con el tratamiento con curcumina tambi\u00e9n se detectaron in vitro.<\/p>\n<p>RESULTADOS: La curcumina podr\u00eda suprimir el crecimiento de c\u00e9lulas cancerosas de colon en el modelo de rat\u00f3n. Esta actividad antitumoral de la curcumina se ejerci\u00f3 inhibiendo la proliferaci\u00f3n celular en lugar de promover la apoptosis celular. Un estudio adicional sugiri\u00f3 que la curcumina inhib\u00eda la proliferaci\u00f3n celular al suprimir la v\u00eda Wnt \/ \u03b2-catenina. MiR-130a fue regulado a la baja por el tratamiento con curcumina, y la sobreexpresi\u00f3n de miR-130a podr\u00eda abolir la actividad antitumoral de la curcumina.<\/p>\n<p>CONCLUSION: Nuestro estudio confirma que la curcumina es capaz de inhibir el c\u00e1ncer de colon al suprimir las v\u00edas Wnt \/ \u03b2-catenina a trav\u00e9s de miR-130a. MiR-130a puede servir como un nuevo objetivo de la curcumina para el tratamiento del CCR.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dou, H., Shen, R., Tao, J., Huang, L., Shi, H., Chen, H., &#8230; &amp; Wang, T. (2017). Curcumin suppresses the colon cancer proliferation by inhibiting Wnt\/\u03b2-catenin pathways via miR-130a.\u00a0Frontiers in pharmacology, 8, 877. FONDO: La curcumina exhibe efectos antitumorales en varios c\u00e1nceres, incluido el carcinoma colorrectal (CCR), pero los mecanismos detallados a\u00fan no est\u00e1n claros. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-44987","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina suprime la proliferaci\u00f3n del c\u00e1ncer de colon al inhibir las v\u00edas Wnt \/ \u03b2-catenina a trav\u00e9s de miR-130a&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=44987\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina suprime la proliferaci\u00f3n del c\u00e1ncer de colon al inhibir las v\u00edas Wnt \/ \u03b2-catenina a trav\u00e9s de miR-130a&quot; -\" \/>\n<meta property=\"og:description\" content=\"Dou, H., Shen, R., Tao, J., Huang, L., Shi, H., Chen, H., &#8230; &amp; Wang, T. (2017). Curcumin suppresses the colon cancer proliferation by inhibiting Wnt\/\u03b2-catenin pathways via miR-130a.\u00a0Frontiers in pharmacology, 8, 877. FONDO: La curcumina exhibe efectos antitumorales en varios c\u00e1nceres, incluido el carcinoma colorrectal (CCR), pero los mecanismos detallados a\u00fan no est\u00e1n claros. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=44987\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-29T23:30:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-30T13:39:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-pnu-blGLBu0\/X8T1kN9Vg-I\/AAAAAAAAg8Q\/0ECxGEgz8fs6dOlSd8thIh51Xi3qpVuRACLcBGAsYHQ\/s320\/frontiers_pharmacology2.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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