{"id":45000,"date":"2020-11-30T05:30:15","date_gmt":"2020-11-30T04:30:15","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45000"},"modified":"2020-12-03T21:44:18","modified_gmt":"2020-12-03T20:44:18","slug":"45000","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45000","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLa deficiencia de vitamina A causa hiperglucemia y p\u00e9rdida de masa pancre\u00e1tica\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-temwyIP8gGI\/X8lNQRVGR_I\/AAAAAAAAg9I\/ZAvdKyjDIpgmPd7cF9ztKxWWdxci6UtewCLcBGAsYHQ\/s259\/Journal_Biological%2BChemistry.gif\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-temwyIP8gGI\/X8lNQRVGR_I\/AAAAAAAAg9I\/ZAvdKyjDIpgmPd7cF9ztKxWWdxci6UtewCLcBGAsYHQ\/s0\/Journal_Biological%2BChemistry.gif\" border=\"0\" data-original-height=\"259\" data-original-width=\"200\" \/><\/a>Trasino, S. E., Benoit, Y. D., &amp; Gudas, L. J. (2015). <a href=\"https:\/\/www.jbc.org\/content\/290\/3\/1456.long\">Vitamin A deficiency causes hyperglycemia and loss of pancreatic \u03b2-cell mass.<\/a>\u00a0<i>Journal of biological chemistry,<\/i>\u00a0290(3), 1456-1473.<\/p>\n<p>Mostramos que la vitamina A (all-trans-retinol) (VA) se requiere tanto para el mantenimiento de la c\u00e9lula pancre\u00e1tica como de la masa celular y para la secreci\u00f3n de insulina estimulada por la glucosa en ratones adultos. La privaci\u00f3n de VA en la dieta (VAD) causa una gran disminuci\u00f3n del p\u00e1ncreas, hiperglucemia y reducci\u00f3n de la secreci\u00f3n de insulina.<\/p>\n<p>Los ratones alimentados con dietas VAD muestran una remodelaci\u00f3n del p\u00e1ncreas endocrino, apoptosis celular marcada, cambios en las distribuciones del tama\u00f1o de los islotes, disminuci\u00f3n de la masa celular, aumento de la masa celular, e hiperglucagonemia. Es importante, aunque indujimos el VAD en todo el animal, las c\u00e9lulas del p\u00e1ncreas son exquisitamente sensibles a la apoptosis asociada a la VAD en comparaci\u00f3n con otros tipos de c\u00e9lulas en otros \u00f3rganos. El DAV causa grandes reducciones en los niveles de la VA la prote\u00edna de uni\u00f3n intracelular Crbp1 y la enzima metabolizadora del \u00e1cido retinoico Cyp26a1 espec\u00edficamente en islotes m\u00e1s grandes, lo que sugiere el uso de estas prote\u00ednas como biomarcadores para las anormalidades endocrinas tempranas de la masa. En los ratones VAD, la reducci\u00f3n del tama\u00f1o de los islotes pancre\u00e1ticos y las funciones endocrinas aberrantes asociadas, que muestran similitudes con el fenotipo en el tipo avanzado 2 diabetes, resultado de la reducci\u00f3n de la se\u00f1alizaci\u00f3n de la AV pancre\u00e1tica.<\/p>\n<p>La reintroducci\u00f3n de la VA diet\u00e9tica a los ratones VAD restaura el p\u00e1ncreas, el control glic\u00e9mico, distribuciones normales del tama\u00f1o de los islotes, proporciones entre c\u00e9lulas, perfiles de hormonas endocrinas y RAR2&#8230;y los niveles de transcripci\u00f3n de RAR2. La restauraci\u00f3n de la masa celular mediante la reintroducci\u00f3n de VA a los ratones VAD no implica un aumento de la masa celular proliferaci\u00f3n o neog\u00e9nesis. La modulaci\u00f3n farmacol\u00f3gica de la se\u00f1alizaci\u00f3n de la AV pancre\u00e1tica debe ser explorada para la preservaci\u00f3n y\/o la restauraci\u00f3n de la masa y funci\u00f3n de las c\u00e9lulas pancre\u00e1ticas en individuos con diabetes mellitus.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Trasino, S. E., Benoit, Y. D., &amp; Gudas, L. J. (2015). Vitamin A deficiency causes hyperglycemia and loss of pancreatic \u03b2-cell mass.\u00a0Journal of biological chemistry,\u00a0290(3), 1456-1473. Mostramos que la vitamina A (all-trans-retinol) (VA) se requiere tanto para el mantenimiento de la c\u00e9lula pancre\u00e1tica como de la masa celular y para la secreci\u00f3n de insulina estimulada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-45000","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;La deficiencia de vitamina A causa hiperglucemia y p\u00e9rdida de masa pancre\u00e1tica&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45000\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;La deficiencia de vitamina A causa hiperglucemia y p\u00e9rdida de masa pancre\u00e1tica&quot; -\" \/>\n<meta property=\"og:description\" content=\"Trasino, S. E., Benoit, Y. D., &amp; Gudas, L. J. (2015). Vitamin A deficiency causes hyperglycemia and loss of pancreatic \u03b2-cell mass.\u00a0Journal of biological chemistry,\u00a0290(3), 1456-1473. 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