{"id":45088,"date":"2020-12-05T04:30:25","date_gmt":"2020-12-05T03:30:25","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45088"},"modified":"2020-12-06T10:46:58","modified_gmt":"2020-12-06T09:46:58","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-inhibe-la-proliferacion-y-la-invasion-de-las-celulas-del-osteosarcoma-mediante-la-inactivacion-de-la-senalizacion","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45088","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina inhibe la proliferaci\u00f3n y la invasi\u00f3n de las c\u00e9lulas del osteosarcoma mediante la inactivaci\u00f3n de la se\u00f1alizaci\u00f3n Notch-1\u00bb!"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-7M5XisPeUew\/X8ynNw_oLZI\/AAAAAAAAhDA\/ypANXwbxZsMtHWLEnzMdxBiHGIAAa5arwCLcBGAsYHQ\/s631\/FEBES_Journal.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-7M5XisPeUew\/X8ynNw_oLZI\/AAAAAAAAhDA\/ypANXwbxZsMtHWLEnzMdxBiHGIAAa5arwCLcBGAsYHQ\/s320\/FEBES_Journal.jpg\" height=\"320\" border=\"0\" data-original-height=\"631\" data-original-width=\"480\" \/><\/a>Li, Y., Zhang, J., Ma, D., Zhang, L., Si, M., Yin, H., &amp; Li, J. (2012).\u00a0<a href=\"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1742-4658.2012.08607.x\">Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch\u20101 signaling<\/a>.\u00a0<i>The FEBS journal<\/i>, 279(12), 2247-2259.<\/p>\n<p>CONTEXTO: La v\u00eda de se\u00f1alizaci\u00f3n de Notch juega un papel fundamental en los c\u00e1nceres humanos, incluido el osteosarcoma, lo que sugiere que el descubrimiento de agentes espec\u00edficos dirigidos a Notch ser\u00eda extremadamente valioso para el osteosarcoma. Se ha demostrado que la curcumina, un compuesto fen\u00f3lico natural que se encuentra en la curcuma longa, inhibe la proliferaci\u00f3n e induce la apoptosis de las c\u00e9lulas del osteosarcoma in vitro y el crecimiento tumoral en modelos de xenotrasplante u ortotrasplante. Sin embargo, los mecanismos moleculares precisos por los que la curcumina ejerce su actividad antitumoral siguen sin estar claros.<\/p>\n<p>METODOLOG\u00cdA: Aqu\u00ed utilizamos m\u00faltiples enfoques moleculares, como el ensayo de bromuro de 3\u2010 (4,5 \u2010 dimetiltiazol \u2010 2 \u2010 il) \u20102,5 \u2010 difeniltetrazolio, el ensayo de invasi\u00f3n, la transfecci\u00f3n de genes, la RT \u2010 PCR en tiempo real, la transferencia Western y la gelatina zimograf\u00eda, para investigar si la regulaci\u00f3n a la baja de Notch \u2010 1 contribuye a la inhibici\u00f3n de la proliferaci\u00f3n e invasi\u00f3n inducida por la curcumina en las c\u00e9lulas del osteosarcoma.<\/p>\n<p>RESULTADOS: Los resultados mostraron que la curcumina provoc\u00f3 una marcada inhibici\u00f3n del crecimiento de las c\u00e9lulas del osteosarcoma y la detenci\u00f3n del ciclo celular en la fase G2 \/ M. Esto se asoci\u00f3 con la atenuaci\u00f3n concomitante de Notch-1 y la regulaci\u00f3n a la baja de sus genes posteriores, como las metaloproteinasas de la matriz, lo que result\u00f3 en la inhibici\u00f3n de la invasi\u00f3n de c\u00e9lulas de osteosarcoma a trav\u00e9s de Matrigel. Tambi\u00e9n se encontr\u00f3 que la regulaci\u00f3n a la baja espec\u00edfica de Notch \u2010 1 a trav\u00e9s del ARN de peque\u00f1a interferencia antes del tratamiento con curcumina result\u00f3 en una mayor inhibici\u00f3n del crecimiento celular y la invasi\u00f3n.<\/p>\n<p>CONCLUSIONES: Estos resultados sugieren que la actividad antitumoral de la curcumina est\u00e1 mediada por un mecanismo novedoso que implica la inactivaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n Notch-1. Nuestros datos proporcionan la primera evidencia de que la regulaci\u00f3n a la baja de Notch \u2010 1 por la curcumina puede ser un enfoque eficaz para el tratamiento del osteosarcoma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li, Y., Zhang, J., Ma, D., Zhang, L., Si, M., Yin, H., &amp; Li, J. (2012).\u00a0Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch\u20101 signaling.\u00a0The FEBS journal, 279(12), 2247-2259. CONTEXTO: La v\u00eda de se\u00f1alizaci\u00f3n de Notch juega un papel fundamental en los c\u00e1nceres humanos, incluido el osteosarcoma, lo que sugiere que el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45088","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina inhibe la proliferaci\u00f3n y la invasi\u00f3n de las c\u00e9lulas del osteosarcoma mediante la inactivaci\u00f3n de la se\u00f1alizaci\u00f3n Notch-1&quot;! -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45088\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina inhibe la proliferaci\u00f3n y la invasi\u00f3n de las c\u00e9lulas del osteosarcoma mediante la inactivaci\u00f3n de la se\u00f1alizaci\u00f3n Notch-1&quot;! -\" \/>\n<meta property=\"og:description\" content=\"Li, Y., Zhang, J., Ma, D., Zhang, L., Si, M., Yin, H., &amp; Li, J. (2012).\u00a0Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch\u20101 signaling.\u00a0The FEBS journal, 279(12), 2247-2259. CONTEXTO: La v\u00eda de se\u00f1alizaci\u00f3n de Notch juega un papel fundamental en los c\u00e1nceres humanos, incluido el osteosarcoma, lo que sugiere que el [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45088\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-05T03:30:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-06T09:46:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-7M5XisPeUew\/X8ynNw_oLZI\/AAAAAAAAhDA\/ypANXwbxZsMtHWLEnzMdxBiHGIAAa5arwCLcBGAsYHQ\/s320\/FEBES_Journal.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45088#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45088\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina inhibe la proliferaci\u00f3n y la invasi\u00f3n de las c\u00e9lulas del osteosarcoma mediante la inactivaci\u00f3n de la se\u00f1alizaci\u00f3n Notch-1\u00bb!\",\"datePublished\":\"2020-12-05T03:30:25+00:00\",\"dateModified\":\"2020-12-06T09:46:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45088\"},\"wordCount\":427,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=45088#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45088\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45088\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"La curcumina inhibe la proliferaci\u00f3n y la invasi\u00f3n de las c\u00e9lulas del osteosarcoma mediante la inactivaci\u00f3n de la se\u00f1alizaci\u00f3n Notch-1\\\"! 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(2012).\u00a0Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch\u20101 signaling.\u00a0The FEBS journal, 279(12), 2247-2259. CONTEXTO: La v\u00eda de se\u00f1alizaci\u00f3n de Notch juega un papel fundamental en los c\u00e1nceres humanos, incluido el osteosarcoma, lo que sugiere que el [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=45088","article_published_time":"2020-12-05T03:30:25+00:00","article_modified_time":"2020-12-06T09:46:58+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-7M5XisPeUew\/X8ynNw_oLZI\/AAAAAAAAhDA\/ypANXwbxZsMtHWLEnzMdxBiHGIAAa5arwCLcBGAsYHQ\/s320\/FEBES_Journal.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45088#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45088"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina inhibe la proliferaci\u00f3n y la invasi\u00f3n de las c\u00e9lulas del osteosarcoma mediante la inactivaci\u00f3n de la se\u00f1alizaci\u00f3n Notch-1\u00bb!","datePublished":"2020-12-05T03:30:25+00:00","dateModified":"2020-12-06T09:46:58+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45088"},"wordCount":427,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=45088#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45088","url":"https:\/\/rina.naturopatiadigital.eu\/?p=45088","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina inhibe la proliferaci\u00f3n y la invasi\u00f3n de las c\u00e9lulas del osteosarcoma mediante la inactivaci\u00f3n de la se\u00f1alizaci\u00f3n Notch-1\"! 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