{"id":45092,"date":"2020-12-05T06:30:21","date_gmt":"2020-12-05T05:30:21","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45092"},"modified":"2020-12-06T11:07:36","modified_gmt":"2020-12-06T10:07:36","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-tomatidina-inhibe-la-invasion-de-la-celula-de-adenocarcinoma-de-pulmon-humano-a549-al-reducir-la-expresion-de-metaloproteina","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45092","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa tomatidina inhibe la invasi\u00f3n de la c\u00e9lula de adenocarcinoma de pulm\u00f3n humano A549 al reducir la expresi\u00f3n de metaloproteinasas de la matriz\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-5_fKLDPhrBY\/X8ytBlL4kJI\/AAAAAAAAhDU\/kP4fv_s2b-Uzk6K0LKHd4nT8NK0USvMxwCLcBGAsYHQ\/s768\/Chemico_Biological%2BInteractions.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-5_fKLDPhrBY\/X8ytBlL4kJI\/AAAAAAAAhDU\/kP4fv_s2b-Uzk6K0LKHd4nT8NK0USvMxwCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg\" height=\"320\" border=\"0\" data-original-height=\"768\" data-original-width=\"576\" \/><\/a>Yan, K. H., Lee, L. M., Yan, S. H., Huang, H. C., Li, C. C., Lin, H. T., &amp; Chen, P. S. (2013).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0009279713000781\">Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression<\/a>.\u00a0<i>Chemico-biological interactions<\/i>, 203(3), 580-587.<\/p>\n<p>CONTEXTO: La tomatidina es una aglicona del glicoalcaloide tomatina en tomate. Se ha descubierto que la tomatidina posee propiedades antiinflamatorias y puede servir como quimiosensibilizador en c\u00e9lulas tumorales resistentes a m\u00faltiples f\u00e1rmacos. Sin embargo, el efecto de la tomatidina sobre la met\u00e1stasis de las c\u00e9lulas cancerosas sigue sin estar claro.<\/p>\n<p>OBJETIVO: Este estudio examina el efecto de la tomatidina sobre la migraci\u00f3n y la invasi\u00f3n de c\u00e9lulas de adenocarcinoma de pulm\u00f3n humano A549 in vitro.<\/p>\n<p>METODO \/ RESULTADOS: Los datos demuestran que la tomatidina no inhibe eficazmente la viabilidad de las c\u00e9lulas A549. Cuando se trata con dosis no t\u00f3xicas de tomatidina, el ensayo de invasi\u00f3n de la c\u00e1mara de Boyden suprime notablemente la invasi\u00f3n celular, mientras que la migraci\u00f3n celular no se ve afectada. La tomatidina reduce el nivel de ARNm de la metaloproteinasa-2 de la matriz (MMP-2), MMP-9 y aumenta la expresi\u00f3n de prote\u00edna rica en ciste\u00edna inductora de reversi\u00f3n con motivos kazal (RECK), as\u00ed como inhibidor tisular de la metaloproteinasa-1 (TIMP- 1). Los ensayos de inmunotransferencia indican que la tomatidina es muy eficaz para suprimir la fosforilaci\u00f3n de Akt y la quinasa reguladora de se\u00f1ales extracelulares (ERK). Adem\u00e1s, la tomatidina reduce significativamente el nivel nuclear del factor nuclear kappa B (NF-\u03baB), lo que sugiere que la tomatidina inhibe la actividad de NF-\u03baB. Adem\u00e1s, el tratamiento de inhibidores espec\u00edficos de PI3K \/ Akt (LY294002), ERK (U0126) o NF-\u03baB (ditiocarbamato de pirrolidina) para las c\u00e9lulas A549 redujo la invasi\u00f3n celular y la expresi\u00f3n de MMP-2\/9.<\/p>\n<p>CONCLUSION: Los resultados sugieren que la tomatidina inhibe la invasi\u00f3n de c\u00e9lulas A549 al reducir la expresi\u00f3n de MMP. Tambi\u00e9n inhibe las v\u00edas de se\u00f1alizaci\u00f3n ERK y Akt y la actividad de NF-\u03baB. Estos hallazgos demuestran un nuevo potencial terap\u00e9utico de la tomatidina en la terapia antimetast\u00e1sica.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yan, K. H., Lee, L. M., Yan, S. H., Huang, H. C., Li, C. C., Lin, H. T., &amp; Chen, P. S. (2013).\u00a0Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.\u00a0Chemico-biological interactions, 203(3), 580-587. CONTEXTO: La tomatidina es una aglicona del glicoalcaloide tomatina en tomate. Se ha descubierto que la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45092","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La tomatidina inhibe la invasi\u00f3n de la c\u00e9lula de adenocarcinoma de pulm\u00f3n humano A549 al reducir la expresi\u00f3n de metaloproteinasas de la matriz&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45092\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La tomatidina inhibe la invasi\u00f3n de la c\u00e9lula de adenocarcinoma de pulm\u00f3n humano A549 al reducir la expresi\u00f3n de metaloproteinasas de la matriz&quot; -\" \/>\n<meta property=\"og:description\" content=\"Yan, K. H., Lee, L. M., Yan, S. H., Huang, H. C., Li, C. C., Lin, H. T., &amp; Chen, P. S. (2013).\u00a0Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.\u00a0Chemico-biological interactions, 203(3), 580-587. CONTEXTO: La tomatidina es una aglicona del glicoalcaloide tomatina en tomate. Se ha descubierto que la [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45092\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-05T05:30:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-06T10:07:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-5_fKLDPhrBY\/X8ytBlL4kJI\/AAAAAAAAhDU\/kP4fv_s2b-Uzk6K0LKHd4nT8NK0USvMxwCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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Se ha descubierto que la [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=45092","article_published_time":"2020-12-05T05:30:21+00:00","article_modified_time":"2020-12-06T10:07:36+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-5_fKLDPhrBY\/X8ytBlL4kJI\/AAAAAAAAhDU\/kP4fv_s2b-Uzk6K0LKHd4nT8NK0USvMxwCLcBGAsYHQ\/s320\/Chemico_Biological%2BInteractions.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45092#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45092"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa tomatidina inhibe la invasi\u00f3n de la c\u00e9lula de 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