{"id":45144,"date":"2020-12-09T06:30:06","date_gmt":"2020-12-09T05:30:06","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45144"},"modified":"2020-12-08T14:45:23","modified_gmt":"2020-12-08T13:45:23","slug":"area-de-conocimiento-naturopatia-descriptiva-el-sistema-inmunologico-adaptativo-en-la-esclerosis-multiple-un-punto-de-vista-mediado-por-estrogenos","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45144","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abEl sistema inmunol\u00f3gico adaptativo en la esclerosis m\u00faltiple: un punto de vista mediado por estr\u00f3genos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-uTQ4v0ZfIkI\/X8-C2GXq0wI\/AAAAAAAAhHg\/LI7NKKY3egEcjOBOxc8IkyNPK018ngReQCLcBGAsYHQ\/s924\/Cells.png\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-uTQ4v0ZfIkI\/X8-C2GXq0wI\/AAAAAAAAhHg\/LI7NKKY3egEcjOBOxc8IkyNPK018ngReQCLcBGAsYHQ\/s320\/Cells.png\" width=\"320\" border=\"0\" data-original-height=\"292\" data-original-width=\"924\" \/><\/a>Maglione, A., Rolla, S., Mercanti, S. F. D., Cutrupi, S., &amp; Clerico, M. (2019).\u00a0<a href=\"https:\/\/www.mdpi.com\/2073-4409\/8\/10\/1280\/htm\">The Adaptive Immune System in Multiple Sclerosis: An Estrogen-Mediated Point of View<\/a>.\u00a0<i>Cells<\/i>, 8(10), 1280.<\/p>\n<p>La esclerosis m\u00faltiple (EM) es una enfermedad inflamatoria cr\u00f3nica del sistema nervioso central que conduce a la desmielinizaci\u00f3n y la neurodegeneraci\u00f3n. Se ha demostrado que el tercer trimestre del embarazo, que se caracteriza por niveles altos de estr\u00f3genos, se asocia con tasas de reca\u00edda reducidas en comparaci\u00f3n con las tasas antes del embarazo. Estos efectos podr\u00edan estar relacionados con las propiedades antiinflamatorias de los estr\u00f3genos, que orquestan la reorganizaci\u00f3n del sistema inmunol\u00f3gico hacia la inmunotolerancia para permitir el crecimiento fetal.<\/p>\n<p>La acci\u00f3n de estas hormonas est\u00e1 mediada por la actividad de regulaci\u00f3n transcripcional de los receptores de estr\u00f3genos (RE). Los niveles de estr\u00f3geno y la expresi\u00f3n de ER definen un equilibrio espec\u00edfico de tipos de c\u00e9lulas inmunes.<\/p>\n<p>En esta revisi\u00f3n, exploramos el papel del estradiol (E2) y los RE en el sistema inmune adaptativo, con un enfoque en los mecanismos celulares, moleculares y epigen\u00e9ticos mediados por estr\u00f3genos relacionados con la tolerancia inmune y la neuroprotecci\u00f3n en la EM. La din\u00e1mica del epigenoma de los sistemas inmunitarios se describe como mecanismos moleculares clave que act\u00faan sobre la regulaci\u00f3n de la identidad de las c\u00e9lulas inmunitarias.<\/p>\n<p>Este es un campo completamente inexplorado, lo que sugiere un camino futuro para una investigaci\u00f3n m\u00e1s extensa sobre los complejos correguladores inducidos por estr\u00f3genos y los circuitos moleculares como objetivos para la terap\u00e9utica en la EM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maglione, A., Rolla, S., Mercanti, S. F. D., Cutrupi, S., &amp; Clerico, M. (2019).\u00a0The Adaptive Immune System in Multiple Sclerosis: An Estrogen-Mediated Point of View.\u00a0Cells, 8(10), 1280. La esclerosis m\u00faltiple (EM) es una enfermedad inflamatoria cr\u00f3nica del sistema nervioso central que conduce a la desmielinizaci\u00f3n y la neurodegeneraci\u00f3n. Se ha demostrado que el tercer trimestre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-45144","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;El sistema inmunol\u00f3gico adaptativo en la esclerosis m\u00faltiple: un punto de vista mediado por estr\u00f3genos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45144\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;El sistema inmunol\u00f3gico adaptativo en la esclerosis m\u00faltiple: un punto de vista mediado por estr\u00f3genos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Maglione, A., Rolla, S., Mercanti, S. F. D., Cutrupi, S., &amp; Clerico, M. (2019).\u00a0The Adaptive Immune System in Multiple Sclerosis: An Estrogen-Mediated Point of View.\u00a0Cells, 8(10), 1280. La esclerosis m\u00faltiple (EM) es una enfermedad inflamatoria cr\u00f3nica del sistema nervioso central que conduce a la desmielinizaci\u00f3n y la neurodegeneraci\u00f3n. Se ha demostrado que el tercer trimestre [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45144\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-09T05:30:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-08T13:45:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-uTQ4v0ZfIkI\/X8-C2GXq0wI\/AAAAAAAAhHg\/LI7NKKY3egEcjOBOxc8IkyNPK018ngReQCLcBGAsYHQ\/s320\/Cells.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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