{"id":45153,"date":"2020-12-10T03:30:57","date_gmt":"2020-12-10T02:30:57","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45153"},"modified":"2020-12-10T20:10:20","modified_gmt":"2020-12-10T19:10:20","slug":"area-de-conocimiento-tecnologia-naturopatica-o-naturopatia-aplicada-modulo-naturopatia-alimentaria-trofologia-el-ayuno-a-corto-plazo-induce-una-autofagia-neuronal-profunda","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45153","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abEl ayuno a corto plazo induce una autofagia neuronal profunda\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-9X4Ycsav1qE\/X9JyMF2rx6I\/AAAAAAAAhIU\/6Am6iBVXkEEtN67u9Uw2Rc5QPpPtZ0aFwCLcBGAsYHQ\/s1937\/Autophagy3.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-9X4Ycsav1qE\/X9JyMF2rx6I\/AAAAAAAAhIU\/6Am6iBVXkEEtN67u9Uw2Rc5QPpPtZ0aFwCLcBGAsYHQ\/s320\/Autophagy3.jpg\" height=\"320\" border=\"0\" data-original-height=\"1937\" data-original-width=\"1500\" \/><\/a>Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., &amp; Kiosses, W. B. (2010).\u00a0<a href=\"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/auto.6.6.12376?needAccess=true&amp;\">Short-term fasting induces profound neuronal autophagy<\/a>.\u00a0<i>Autophagy<\/i>, 6(6), 702-710.<\/p>\n<p>La interrupci\u00f3n de la autofagia, un proceso homeost\u00e1tico clave en el que los componentes citos\u00f3licos se degradan y reciclan a trav\u00e9s de los lisosomas, puede causar neurodegeneraci\u00f3n en cultivos de tejidos e in vivo. La sobrerregulaci\u00f3n de esta v\u00eda puede ser neuroprotectora, y se est\u00e1 invirtiendo mucho esfuerzo en desarrollar f\u00e1rmacos que atraviesen la barrera hematoencef\u00e1lica y aumenten la autofagia neuronal.<\/p>\n<p>Una forma bien conocida de inducir la autofagia es mediante la restricci\u00f3n de alimentos, que regula al alza la autofagia en muchos \u00f3rganos, incluido el h\u00edgado; pero el dogma actual sostiene que el cerebro escapa a este efecto, quiz\u00e1s porque es un sitio metab\u00f3licamente privilegiado.<\/p>\n<p>Aqu\u00ed, hemos reevaluado este principio utilizando un enfoque novedoso que nos permite detectar, enumerar y caracterizar autofagosomas in vivo. Primero validamos el enfoque mostrando que permite la identificaci\u00f3n y caracterizaci\u00f3n de autofagosomas en el h\u00edgado de ratones con restricci\u00f3n alimentaria. Usamos el m\u00e9todo para identificar autofagosomas constitutivos en neuronas corticales y c\u00e9lulas de Purkinje, y mostramos que el ayuno a corto plazo conduce a una regulaci\u00f3n al alza dram\u00e1tica en la autofagia neuronal.<\/p>\n<p>El aumento de la autofagia neuronal se revela por cambios en la abundancia y caracter\u00edsticas del autofagosoma, y \u200b\u200bpor la disminuci\u00f3n de la actividad neuronal de mTOR in vivo, demostrada por una reducci\u00f3n en los niveles de prote\u00edna ribos\u00f3mica S6 fosforilada en c\u00e9lulas de Purkinje. La mayor abundancia de autofagosomas en las c\u00e9lulas de Purkinje se confirm\u00f3 mediante microscop\u00eda electr\u00f3nica de transmisi\u00f3n.<\/p>\n<p>CONCLUSION: Nuestros datos nos llevan a especular que el ayuno espor\u00e1dico podr\u00eda representar un medio simple, seguro y econ\u00f3mico para promover esta respuesta neuronal potencialmente terap\u00e9utica.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., &amp; Kiosses, W. B. (2010).\u00a0Short-term fasting induces profound neuronal autophagy.\u00a0Autophagy, 6(6), 702-710. La interrupci\u00f3n de la autofagia, un proceso homeost\u00e1tico clave en el que los componentes citos\u00f3licos se degradan y reciclan a trav\u00e9s de los lisosomas, puede causar neurodegeneraci\u00f3n en cultivos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-45153","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;El ayuno a corto plazo induce una autofagia neuronal profunda&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45153\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;El ayuno a corto plazo induce una autofagia neuronal profunda&quot; -\" \/>\n<meta property=\"og:description\" content=\"Alirezaei, M., Kemball, C. C., Flynn, C. T., Wood, M. R., Whitton, J. L., &amp; Kiosses, W. B. (2010).\u00a0Short-term fasting induces profound neuronal autophagy.\u00a0Autophagy, 6(6), 702-710. 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