{"id":45185,"date":"2020-12-16T03:30:55","date_gmt":"2020-12-16T02:30:55","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45185"},"modified":"2020-12-16T16:06:21","modified_gmt":"2020-12-16T15:06:21","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-asociacion-de-trastornos-inmunologicos-en-el-efecto-secundario-letal-de-los-aines-en-ratones-a-los-que-se-les-administro-betagl","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45185","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abAsociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-4MC5JNAg_0A\/X9ohOhf2rQI\/AAAAAAAAhNM\/6AAgvOTL3fE48seDQBeIZFxLrg2NBzIowCLcBGAsYHQ\/s263\/FEMS_%2BImmunology%2B%2526%2BMedical%2BMicrobiology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-4MC5JNAg_0A\/X9ohOhf2rQI\/AAAAAAAAhNM\/6AAgvOTL3fE48seDQBeIZFxLrg2NBzIowCLcBGAsYHQ\/s0\/FEMS_%2BImmunology%2B%2526%2BMedical%2BMicrobiology.jpg\" border=\"0\" data-original-height=\"263\" data-original-width=\"191\" \/><\/a>Takahashi, H., Ohno, N., Adachi, Y., &amp; Yadomae, T. (2001). <a href=\"https:\/\/academic.oup.com\/femspd\/article\/31\/1\/1\/576717\">Association of immunological disorders in lethal side effect of NSAIDs on \u03b2-glucan-administered mice.<\/a> <em>FEMS Immunology &amp; Medical Microbiology<\/em>, 31(1), 1-14.<\/p>\n<div>\n<p>(1 \u2192 3) -\u03b2-D-Glucano (\u03b2-glucano) es un modificador de la respuesta biol\u00f3gica que regula la respuesta inmune del hu\u00e9sped. Hemos encontrado que la combinaci\u00f3n de un \u03b2-glucano y un f\u00e1rmaco antiinflamatorio no esteroideo (AINEs), indometacina (IND), indujo toxicidad letal en ratones [Yoshioka et al. (1998) <em>FEMS Immunol. Medicina. Microbiol<\/em>., 21, 171-179].<\/p>\n<p>Este estudio se realiz\u00f3 para analizar el mecanismo del efecto secundario letal. La combinaci\u00f3n de un \u03b2-glucano e IND aument\u00f3 el n\u00famero de leucocitos, especialmente macr\u00f3fagos y neutr\u00f3filos, en varios \u00f3rganos y estas c\u00e9lulas se activaron. El estado activado de estas c\u00e9lulas fue apoyado por la producci\u00f3n mejorada de interfer\u00f3n-\u03b3 en presencia de cultivo in vitro de IND de las c\u00e9lulas del exudado peritoneal.<\/p>\n<p>La flora bacteriana intestinal se trasloc\u00f3 a la cavidad peritoneal en estos ratones para causar peritonitis. Al comparar la toxicidad de varios AINEs, la nabumetona, un AINE parcialmente selectivo para ciclooxigenasa-2 con una toxicidad m\u00e1s d\u00e9bil para el tracto gastrointestinal, no mostr\u00f3 un efecto secundario letal.<\/p>\n<p>Estos hechos sugirieron fuertemente que el da\u00f1o gastrointestinal por los AINEs fue m\u00e1s severo en ratones a los que se les administr\u00f3 \u03b2-glucano, lo que result\u00f3 en peritonitis por bacterias ent\u00e9ricas y condujo a la muerte.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Takahashi, H., Ohno, N., Adachi, Y., &amp; Yadomae, T. (2001). Association of immunological disorders in lethal side effect of NSAIDs on \u03b2-glucan-administered mice. FEMS Immunology &amp; Medical Microbiology, 31(1), 1-14. (1 \u2192 3) -\u03b2-D-Glucano (\u03b2-glucano) es un modificador de la respuesta biol\u00f3gica que regula la respuesta inmune del hu\u00e9sped. Hemos encontrado que la combinaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45185","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Asociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45185\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Asociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano&quot; -\" \/>\n<meta property=\"og:description\" content=\"Takahashi, H., Ohno, N., Adachi, Y., &amp; Yadomae, T. (2001). Association of immunological disorders in lethal side effect of NSAIDs on \u03b2-glucan-administered mice. FEMS Immunology &amp; Medical Microbiology, 31(1), 1-14. (1 \u2192 3) -\u03b2-D-Glucano (\u03b2-glucano) es un modificador de la respuesta biol\u00f3gica que regula la respuesta inmune del hu\u00e9sped. Hemos encontrado que la combinaci\u00f3n de [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45185\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-16T02:30:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-16T15:06:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-4MC5JNAg_0A\/X9ohOhf2rQI\/AAAAAAAAhNM\/6AAgvOTL3fE48seDQBeIZFxLrg2NBzIowCLcBGAsYHQ\/s0\/FEMS_%2BImmunology%2B%2526%2BMedical%2BMicrobiology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45185#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45185\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abAsociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\u00bb\",\"datePublished\":\"2020-12-16T02:30:55+00:00\",\"dateModified\":\"2020-12-16T15:06:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45185\"},\"wordCount\":270,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=45185#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45185\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45185\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"Asociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2020-12-16T02:30:55+00:00\",\"dateModified\":\"2020-12-16T15:06:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45185#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=45185\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45185#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abAsociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Asociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=45185","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Asociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\" -","og_description":"Takahashi, H., Ohno, N., Adachi, Y., &amp; Yadomae, T. (2001). Association of immunological disorders in lethal side effect of NSAIDs on \u03b2-glucan-administered mice. FEMS Immunology &amp; Medical Microbiology, 31(1), 1-14. (1 \u2192 3) -\u03b2-D-Glucano (\u03b2-glucano) es un modificador de la respuesta biol\u00f3gica que regula la respuesta inmune del hu\u00e9sped. Hemos encontrado que la combinaci\u00f3n de [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=45185","article_published_time":"2020-12-16T02:30:55+00:00","article_modified_time":"2020-12-16T15:06:21+00:00","og_image":[{"url":"https:\/\/1.bp.blogspot.com\/-4MC5JNAg_0A\/X9ohOhf2rQI\/AAAAAAAAhNM\/6AAgvOTL3fE48seDQBeIZFxLrg2NBzIowCLcBGAsYHQ\/s0\/FEMS_%2BImmunology%2B%2526%2BMedical%2BMicrobiology.jpg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45185#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45185"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abAsociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\u00bb","datePublished":"2020-12-16T02:30:55+00:00","dateModified":"2020-12-16T15:06:21+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45185"},"wordCount":270,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=45185#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45185","url":"https:\/\/rina.naturopatiadigital.eu\/?p=45185","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Asociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2020-12-16T02:30:55+00:00","dateModified":"2020-12-16T15:06:21+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45185#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=45185"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45185#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abAsociaci\u00f3n de trastornos inmunol\u00f3gicos en el efecto secundario letal de los AINEs en ratones a los que se les administr\u00f3 betaglucano\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/45185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45185"}],"version-history":[{"count":4,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/45185\/revisions"}],"predecessor-version":[{"id":45189,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/45185\/revisions\/45189"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45185"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}