{"id":45337,"date":"2020-12-26T05:30:48","date_gmt":"2020-12-26T04:30:48","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45337"},"modified":"2020-12-26T20:27:39","modified_gmt":"2020-12-26T19:27:39","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-crocina-dietetica-es-protectora-en-el-cancer-de-pancreas-al-tiempo-que-reduce-el-dano-oxidativo-hepatico-inducido-por-radiac","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45337","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa crocina diet\u00e9tica es protectora en el c\u00e1ncer de p\u00e1ncreas al tiempo que reduce el da\u00f1o oxidativo hep\u00e1tico inducido por radiaci\u00f3n\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-xVg23gwvDEs\/X-eOEVKED5I\/AAAAAAAAhbA\/bPqpCOVNOD04-f8ZZFQpVx67H8QtSm00ACLcBGAsYHQ\/s267\/Nutrients3.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-xVg23gwvDEs\/X-eOEVKED5I\/AAAAAAAAhbA\/bPqpCOVNOD04-f8ZZFQpVx67H8QtSm00ACLcBGAsYHQ\/s0\/Nutrients3.jpg\" border=\"0\" data-original-height=\"267\" data-original-width=\"189\" \/><\/a>Bakshi, H. A., Al Zoubi, M. S., Faruck, H. L., Aljabali, A. A., Rabi, F. A., Hafiz, A. A., &#8230; &amp; Charbe, N. B. (2020). <a href=\"https:\/\/www.mdpi.com\/2072-6643\/12\/6\/1901\/htm\">Dietary crocin is protective in pancreatic cancer while reducing radiation-induced hepatic oxidative damage<\/a>.\u00a0<i>Nutrients<\/i>, 12(6), 1901.<\/p>\n<p>FONDO: El c\u00e1ncer de p\u00e1ncreas es una de las causas fatales de muertes relacionadas con el c\u00e1ncer en todo el mundo. Aunque la cirug\u00eda y la quimioterapia son opciones de tratamiento est\u00e1ndar, los resultados posteriores al tratamiento a menudo terminan en un mal pron\u00f3stico.<\/p>\n<p>OBJETIVO \/ METODO: En el presente estudio, investigamos el c\u00e1ncer de p\u00e1ncreas y la mejora del da\u00f1o oxidativo inducido por la radiaci\u00f3n por la crocina. La crocina es un carotenoide aislado de la hierba diet\u00e9tica azafr\u00e1n, una perspectiva de nuevas pistas como agente contra el c\u00e1ncer.<\/p>\n<p>RESULTADOS: La crocina redujo significativamente la viabilidad celular de BXPC3 y Capan-2 al activar la se\u00f1alizaci\u00f3n de caspasa a trav\u00e9s de la regulaci\u00f3n a la baja de Bcl-2. Modul\u00f3 la expresi\u00f3n de las prote\u00ednas de se\u00f1alizaci\u00f3n del ciclo celular P53, P21, P27, CDK2, c-MYC, Cyt-c y P38. Concomitantemente, la apoptosis inducida por el tratamiento con crocina al inducir la liberaci\u00f3n de citocromo c de las mitocondrias al citosol. El an\u00e1lisis de microarrays de la firma de expresi\u00f3n de genes inducidos por crocina mostr\u00f3 que un n\u00famero sustancial de genes implicados en las v\u00edas de se\u00f1alizaci\u00f3n celular y los puntos de control (723) se ven afectados significativamente por la crocina. En ratones con tumores pancre\u00e1ticos, la crocina redujo significativamente la carga tumoral sin un cambio en el peso corporal. Adem\u00e1s, mostr\u00f3 una protecci\u00f3n significativa contra el da\u00f1o oxidativo hep\u00e1tico inducido por la radiaci\u00f3n, redujo los niveles de toxicidad hep\u00e1tica y conserv\u00f3 la morfolog\u00eda del h\u00edgado.<\/p>\n<p>CONCLUSION: Estos hallazgos indican que la crocina tiene un papel potencial en el tratamiento, la prevenci\u00f3n y el manejo del c\u00e1ncer de p\u00e1ncreas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bakshi, H. A., Al Zoubi, M. S., Faruck, H. L., Aljabali, A. A., Rabi, F. A., Hafiz, A. A., &#8230; &amp; Charbe, N. B. (2020). Dietary crocin is protective in pancreatic cancer while reducing radiation-induced hepatic oxidative damage.\u00a0Nutrients, 12(6), 1901. FONDO: El c\u00e1ncer de p\u00e1ncreas es una de las causas fatales de muertes relacionadas con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45337","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La crocina diet\u00e9tica es protectora en el c\u00e1ncer de p\u00e1ncreas al tiempo que reduce el da\u00f1o oxidativo hep\u00e1tico inducido por radiaci\u00f3n&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45337\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La crocina diet\u00e9tica es protectora en el c\u00e1ncer de p\u00e1ncreas al tiempo que reduce el da\u00f1o oxidativo hep\u00e1tico inducido por radiaci\u00f3n&quot; -\" \/>\n<meta property=\"og:description\" content=\"Bakshi, H. A., Al Zoubi, M. S., Faruck, H. L., Aljabali, A. A., Rabi, F. A., Hafiz, A. A., &#8230; &amp; Charbe, N. B. (2020). Dietary crocin is protective in pancreatic cancer while reducing radiation-induced hepatic oxidative damage.\u00a0Nutrients, 12(6), 1901. 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