{"id":45339,"date":"2020-12-26T06:30:11","date_gmt":"2020-12-26T05:30:11","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45339"},"modified":"2020-12-26T20:38:28","modified_gmt":"2020-12-26T19:38:28","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-crocina-dietetica-revierte-la-metastasis-del-melanoma","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45339","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa crocina diet\u00e9tica revierte la met\u00e1stasis del melanoma\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-Y0fACYYo4TY\/X-eQjL3Fe7I\/AAAAAAAAhbM\/R9ADMMB5Anciyzdu1gAno-DHU2CCwthHACLcBGAsYHQ\/s768\/Journal_Biomedical%2BResearch.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-Y0fACYYo4TY\/X-eQjL3Fe7I\/AAAAAAAAhbM\/R9ADMMB5Anciyzdu1gAno-DHU2CCwthHACLcBGAsYHQ\/s320\/Journal_Biomedical%2BResearch.jpg\" height=\"320\" border=\"0\" data-original-height=\"768\" data-original-width=\"557\" \/><\/a>Bakshi, H. A., Hakkim, F. L., Sam, S., Javid, F., &amp; Rashan, L. (2018). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5956257\/\">Dietary crocin reverses melanoma metastasis<\/a>.<i>\u00a0Journal of Biomedical Research<\/i>, 32(1), 39.<\/p>\n<p>FONDO: Crocus sativus y su crocina constituyente bioactivo son bien conocidos por su potencial antitumoral en diferentes modelos. Sin embargo, todav\u00eda no se ha informado de la eficacia de la crocina en la met\u00e1stasis de melanoma in vivo.<\/p>\n<p>OBJETIVO: En este estudio, el modelo metast\u00e1sico de melanoma se desarroll\u00f3 mediante inyecci\u00f3n en la vena de la cola de c\u00e9lulas B16F-10 en ratones C57BL \/<\/p>\n<p>METODOLOGIA: 6. Ratones metast\u00e1sicos tratados con dos dosis diferentes de crocina (250 y 500 \u00b5g \/ kg de peso corporal) durante 10 d\u00edas y se analizaron par\u00e1metros como inhibici\u00f3n de la met\u00e1stasis pulmonar, tiempo medio de supervivencia, niveles de hidroxiprolina pulmonar, \u00e1cido ur\u00f3nico y hexosamina a los 21 d\u00edas de tratamiento. Luego se extrajo sangre y se midieron los niveles de gamma glutamil transpeptidasa (g-GGT), \u00e1cido si\u00e1lico, factor de necrosis tumoral alfa (TNF-\u03b1), interleucina 10 (IL-10), IL-6, IL-2 y TIMP-1. Medido. Adem\u00e1s, se realiz\u00f3 un examen histol\u00f3gico pulmonar en ratones metast\u00e1sicos tratados con crocina. Posteriormente, se investigaron los par\u00e1metros metast\u00e1sicos caracter\u00edsticos como las metaloproteinasas de la matriz (MMP), la quinasa 2 regulada extracelular (ERK2), el factor de crecimiento endotelial vascular (VEGF) y la expresi\u00f3n del gen K-ras en los pulmones de ratones metast\u00e1sicos tratados con crocina. Adem\u00e1s, se examin\u00f3 la adhesi\u00f3n, invasi\u00f3n y migraci\u00f3n in vitro de c\u00e9lulas B16F-10 despu\u00e9s de 24 horas de tratamiento con crocina (5 y 10 \u00b5g \/ ml).<\/p>\n<p>RESULTADOS: La administraci\u00f3n de crocina a ratones C57BL \/ 6 con tumor redujo la met\u00e1stasis pulmonar en un 85%. Se encontr\u00f3 que los niveles elevados de hidroxiprolina, \u00e1cido ur\u00f3nico, hexosamina, \u00e1cido si\u00e1lico s\u00e9rico y g-GGT en el control metast\u00e1sico se redujeron significativamente en ratones tratados con crocina. La crocina tambi\u00e9n inhibi\u00f3 la expresi\u00f3n de MMP-2, MMP-9, ERK-2, K-ras y VEGF. La crocina redujo la capacidad de invasi\u00f3n de c\u00e9lulas B16F-10 (P &lt;0,05), migraci\u00f3n (P &lt;0,05) y adhesi\u00f3n mediante la regulaci\u00f3n positiva de la expresi\u00f3n de E-cadherina.<\/p>\n<p>CONCLUSION: En conclusi\u00f3n, la crocina provoc\u00f3 un marcado potencial antimetast\u00e1sico al regular los biomarcadores inducidos por met\u00e1stasis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bakshi, H. A., Hakkim, F. L., Sam, S., Javid, F., &amp; Rashan, L. (2018). Dietary crocin reverses melanoma metastasis.\u00a0Journal of Biomedical Research, 32(1), 39. FONDO: Crocus sativus y su crocina constituyente bioactivo son bien conocidos por su potencial antitumoral en diferentes modelos. Sin embargo, todav\u00eda no se ha informado de la eficacia de la crocina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45339","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La crocina diet\u00e9tica revierte la met\u00e1stasis del melanoma&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45339\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La crocina diet\u00e9tica revierte la met\u00e1stasis del melanoma&quot; -\" \/>\n<meta property=\"og:description\" content=\"Bakshi, H. A., Hakkim, F. L., Sam, S., Javid, F., &amp; Rashan, L. (2018). Dietary crocin reverses melanoma metastasis.\u00a0Journal of Biomedical Research, 32(1), 39. FONDO: Crocus sativus y su crocina constituyente bioactivo son bien conocidos por su potencial antitumoral en diferentes modelos. Sin embargo, todav\u00eda no se ha informado de la eficacia de la crocina [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45339\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-26T05:30:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-12-26T19:38:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-Y0fACYYo4TY\/X-eQjL3Fe7I\/AAAAAAAAhbM\/R9ADMMB5Anciyzdu1gAno-DHU2CCwthHACLcBGAsYHQ\/s320\/Journal_Biomedical%2BResearch.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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