{"id":45403,"date":"2021-01-02T04:30:59","date_gmt":"2021-01-02T03:30:59","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45403"},"modified":"2021-01-16T23:10:39","modified_gmt":"2021-01-16T22:10:39","slug":"area-de-conocimiento-naturopatia-descriptiva-la-expresion-del-gen-del-transportador-de-zinc-esta-regulada-por-citocinas-proinflamatorias-un-papel-potencial-de-los-transportadores-de-zinc-en","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45403","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \u00abLa expresi\u00f3n del gen del transportador de zinc est\u00e1 regulada por citocinas proinflamatorias: \u00bfun papel potencial de los transportadores de zinc en la apoptosis de las c\u00e9lulas beta?\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-qeEkM8fW1ZI\/YANgTPh5CtI\/AAAAAAAAhg4\/ne3gyHG2FyY9k1J1AJO4spKOP1Hbmr7wwCLcBGAsYHQ\/s156\/BMC_endocrine%2Bdisorders.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-qeEkM8fW1ZI\/YANgTPh5CtI\/AAAAAAAAhg4\/ne3gyHG2FyY9k1J1AJO4spKOP1Hbmr7wwCLcBGAsYHQ\/s0\/BMC_endocrine%2Bdisorders.jpg\" border=\"0\" data-original-height=\"156\" data-original-width=\"110\" \/><\/a>Egefjord, L., Jensen, J. L., Bang-Berthelsen, C. H., Petersen, A. B., Smidt, K., Schmitz, O., &#8230; &amp; Magnusson, N. E. (2009).<a href=\"https:\/\/link.springer.com\/article\/10.1186\/1472-6823-9-7\"> Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis<\/a>?.\u00a0<i>BMC endocrine disorders<\/i>, 9(1), 7.<\/p>\n<p>ANTECEDENTES: Las c\u00e9lulas \u03b2 son extremadamente ricas en zinc y la homeostasis del zinc est\u00e1 regulada por prote\u00ednas transportadoras de zinc. Las c\u00e9lulas \u03b2 son sensibles a las citocinas, la interleucina-1\u03b2 (IL-1\u03b2) se ha asociado con la disfunci\u00f3n y la muerte de las c\u00e9lulas \u03b2 tanto en la diabetes tipo 1 como en la tipo 2.<\/p>\n<p>OBJETIVO: Este estudio explora la regulaci\u00f3n de los transportadores de zinc despu\u00e9s de la exposici\u00f3n a citocinas.<\/p>\n<p>METODOS: Se midieron los efectos de las citocinas IL-1\u03b2, interfer\u00f3n-\u03b3 (IFN-\u03b3) y factor de necrosis tumoral \u03b1 (TNF-\u03b1) sobre la expresi\u00f3n del gen transportador de zinc en c\u00e9lulas INS-1 e islotes pancre\u00e1ticos de rata. Siendo el transportador m\u00e1s sensible, exploramos a\u00fan m\u00e1s ZnT8 (Slc30A8): se investig\u00f3 el efecto de la sobreexpresi\u00f3n de ZnT8 sobre la apoptosis inducida por citocinas, as\u00ed como la expresi\u00f3n del gen de la insulina y dos genes asociados a la apoptosis, BAX y BCL2.<\/p>\n<p>RESUTADOS: Nuestros resultados mostraron una respuesta din\u00e1mica de los genes responsables de la homeostasis del zinc de las c\u00e9lulas \u03b2 a las citocinas: IL-1\u03b2 regul\u00f3 negativamente una serie de transportadores de zinc, de manera m\u00e1s sorprendente, ZnT8 tanto en los islotes como en las c\u00e9lulas INS-1. El efecto fue a\u00fan m\u00e1s pronunciado cuando se mezclaron las citocinas. El TNF-\u03b1 tuvo poco efecto sobre la expresi\u00f3n del transportador de zinc. El IFN-\u03b3 regula a la baja varios transportadores de zinc. La expresi\u00f3n de insulina estaba regulada negativamente por todas las citocinas. Las c\u00e9lulas que sobreexpresaban ZnT8 eran m\u00e1s sensibles a la apoptosis inducida por IL-1\u03b2 mientras que no se observaron diferencias con IFN-\u03b3, TNF-\u03b1 o una mezcla de citocinas.<\/p>\n<p>CONCLUSION: El sistema de transporte de zinc en las c\u00e9lulas \u03b2 est\u00e1 influenciado por la exposici\u00f3n a las citocinas. Particularmente ZnT8, que se ha asociado con el desarrollo de diabetes, parece ser sensible a las citocinas.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Egefjord, L., Jensen, J. L., Bang-Berthelsen, C. H., Petersen, A. B., Smidt, K., Schmitz, O., &#8230; &amp; Magnusson, N. E. (2009). Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?.\u00a0BMC endocrine disorders, 9(1), 7. ANTECEDENTES: Las c\u00e9lulas \u03b2 son extremadamente ricas en zinc y la homeostasis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-45403","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La expresi\u00f3n del gen del transportador de zinc est\u00e1 regulada por citocinas proinflamatorias: \u00bfun papel potencial de los transportadores de zinc en la apoptosis de las c\u00e9lulas beta?&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45403\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva &quot;La expresi\u00f3n del gen del transportador de zinc est\u00e1 regulada por citocinas proinflamatorias: \u00bfun papel potencial de los transportadores de zinc en la apoptosis de las c\u00e9lulas beta?&quot; -\" \/>\n<meta property=\"og:description\" content=\"Egefjord, L., Jensen, J. L., Bang-Berthelsen, C. H., Petersen, A. B., Smidt, K., Schmitz, O., &#8230; &amp; Magnusson, N. E. (2009). Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?.\u00a0BMC endocrine disorders, 9(1), 7. 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citocinas proinflamatorias: \u00bfun papel potencial de los transportadores de zinc en la apoptosis de las c\u00e9lulas beta?\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=45403","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Descriptiva \"La expresi\u00f3n del gen del transportador de zinc est\u00e1 regulada por citocinas proinflamatorias: \u00bfun papel potencial de los transportadores de zinc en la apoptosis de las c\u00e9lulas beta?\" -","og_description":"Egefjord, L., Jensen, J. 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