{"id":45603,"date":"2021-02-11T02:30:26","date_gmt":"2021-02-11T01:30:26","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45603"},"modified":"2021-02-12T22:26:23","modified_gmt":"2021-02-12T21:26:23","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-genisteina-agota-la-actividad-de-la-telomerasa-a-traves-del-dialogo-cruzado-entre-los-mecanismos-geneticos-y-epigeneticos","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45603","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa geniste\u00edna agota la actividad de la telomerasa a trav\u00e9s del di\u00e1logo cruzado entre los mecanismos gen\u00e9ticos y epigen\u00e9ticos\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/--ELbv2ZytVo\/YCbwNMBKYzI\/AAAAAAAAhvY\/AdedS5gZftEOTI61KPbCPy10BvU7OHb_gCLcBGAsYHQ\/s300\/International_journal%2Bof%2Bcancer.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/--ELbv2ZytVo\/YCbwNMBKYzI\/AAAAAAAAhvY\/AdedS5gZftEOTI61KPbCPy10BvU7OHb_gCLcBGAsYHQ\/s0\/International_journal%2Bof%2Bcancer.jpg\" border=\"0\" data-original-height=\"300\" data-original-width=\"225\" \/><\/a>Li, Y., Liu, L., Andrews, L. G., &amp; Tollefsbol, T. O. (2009).\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.24398\">Genistein depletes telomerase activity through cross\u2010talk between genetic and epigenetic mechanisms<\/a>.\u00a0<i>International journal of cancer<\/i>, 125(2), 286-296.<\/p>\n<p>Se ha informado que la geniste\u00edna, una isoflavona natural que se encuentra en los productos de soja, regula a la baja la actividad de la telomerasa y que esto previene el c\u00e1ncer y contribuye a la apoptosis de las c\u00e9lulas cancerosas. Sin embargo, no est\u00e1 claro el mecanismo molecular preciso por el cual la geniste\u00edna reprime la telomerasa.<\/p>\n<p>Aqu\u00ed, mostramos que la geniste\u00edna inhibe la transcripci\u00f3n de hTERT (transcriptasa inversa de telomerasa humana), la subunidad catal\u00edtica de la enzima telomerasa humana, en c\u00e9lulas benignas de mama MCF10AT y c\u00e9lulas cancerosas MCF-7 de manera dependiente del tiempo y de la dosis.<\/p>\n<p>Tres ADN metiltransferasas principales (DNMT1, 3a y 3b) tambi\u00e9n disminuyeron en las c\u00e9lulas de c\u00e1ncer de mama tratadas con geniste\u00edna, lo que sugiere que la geniste\u00edna puede reprimir la hTERT al afectar las v\u00edas epigen\u00e9ticas. Agotamiento secuencial de hTERTEl promotor revel\u00f3 que la regi\u00f3n promotora del n\u00facleo de hTERT es responsable de la represi\u00f3n de la transcripci\u00f3n de hTERT inducida por geniste\u00edna.<\/p>\n<p>Mediante el uso de una t\u00e9cnica recientemente desarrollada de an\u00e1lisis de secuenciaci\u00f3n de bifulfite relacionada con la inmunoprecipitaci\u00f3n de cromatina (ChIP), se encontr\u00f3 que una mayor uni\u00f3n de E2F \u2010 1 al promotor hTERT se debe a la hipometilaci\u00f3n espec\u00edfica del sitio del sitio de reconocimiento de E2F \u2010 1. Adem\u00e1s, encontramos que la geniste\u00edna puede remodelar las estructuras de cromatina del promotor hTERT aumentando el trimetil-H3K9, pero disminuyendo el dimetil-H3K4 en el promotor hTERT. La represi\u00f3n de hTERTse mejor\u00f3 con la combinaci\u00f3n con geniste\u00edna y el inhibidor de DNMT, 5 \u2010 aza \u2010 2\u2032 \u2010 desoxicitidina (5 \u2010 aza \u2010 dCyd).<\/p>\n<p>CONCLUSIONES: Estos hallazgos muestran colectivamente que la geniste\u00edna est\u00e1 funcionando, al menos en parte, a trav\u00e9s de mecanismos epigen\u00e9ticos de inhibici\u00f3n de la telomerasa en c\u00e9lulas cancerosas y benignas de mama, y \u200b\u200bpuede facilitar los enfoques para la prevenci\u00f3n y el tratamiento del c\u00e1ncer de mama utilizando un modulador epigen\u00e9tico combinado con geniste\u00edna.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li, Y., Liu, L., Andrews, L. G., &amp; Tollefsbol, T. O. (2009).\u00a0Genistein depletes telomerase activity through cross\u2010talk between genetic and epigenetic mechanisms.\u00a0International journal of cancer, 125(2), 286-296. Se ha informado que la geniste\u00edna, una isoflavona natural que se encuentra en los productos de soja, regula a la baja la actividad de la telomerasa y que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45603","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La geniste\u00edna agota la actividad de la telomerasa a trav\u00e9s del di\u00e1logo cruzado entre los mecanismos gen\u00e9ticos y epigen\u00e9ticos&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45603\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La geniste\u00edna agota la actividad de la telomerasa a trav\u00e9s del di\u00e1logo cruzado entre los mecanismos gen\u00e9ticos y epigen\u00e9ticos&quot; -\" \/>\n<meta property=\"og:description\" content=\"Li, Y., Liu, L., Andrews, L. 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