{"id":45607,"date":"2021-02-12T00:30:20","date_gmt":"2021-02-11T23:30:20","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45607"},"modified":"2021-02-12T23:03:14","modified_gmt":"2021-02-12T22:03:14","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-gosipol-suprime-la-actividad-de-la-telomerasa-en-las-celulas-leucemicas-humanas-mediante-la-regulacion-de-htert","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45607","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl gosipol suprime la actividad de la telomerasa en las c\u00e9lulas leuc\u00e9micas humanas mediante la regulaci\u00f3n de hTERT\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-WP0RX2zt4YY\/YCb54TF_B7I\/AAAAAAAAhvw\/w8Vht9BQQ7w64tqMvgnKb6pYxYPGp_JqACLcBGAsYHQ\/s300\/FEBS_letters.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-WP0RX2zt4YY\/YCb54TF_B7I\/AAAAAAAAhvw\/w8Vht9BQQ7w64tqMvgnKb6pYxYPGp_JqACLcBGAsYHQ\/s0\/FEBS_letters.jpg\" border=\"0\" data-original-height=\"300\" data-original-width=\"229\" \/><\/a>Moon, D. O., Kim, M. O., Choi, Y. H., Lee, H. G., Kim, N. D., &amp; Kim, G. Y. (2008). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014579308007163\">Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT<\/a>.\u00a0<i>FEBS letters<\/i>, 582(23-24), 3367-3373.<\/p>\n<div>El gosipol es un compuesto polifen\u00f3lico originalmente aislado de la semilla de algod\u00f3n que se ha utilizado con \u00e9xito durante mucho tiempo como f\u00e1rmaco anticonceptivo para los hombres. Sin embargo, el mecanismo molecular de los efectos anti-telomerasa del gosipol no se comprende del todo.<\/p>\n<p>En este estudio, observamos citotoxicidad directa e inhibici\u00f3n de la actividad de la telomerasa con regulaci\u00f3n a la baja de la expresi\u00f3n de la transcriptasa inversa de la telomerasa (hTERT). El tratamiento con gosipol result\u00f3 en una disminuci\u00f3n de la expresi\u00f3n de c-Myc y de la actividad de uni\u00f3n. El tratamiento con gosipol tambi\u00e9n suprimi\u00f3 la activaci\u00f3n de Akt, inhibiendo as\u00ed la fosforilaci\u00f3n y translocaci\u00f3n de hTERT al n\u00facleo.<\/p>\n<p>CONCLUSION: Concluimos que el gosipol regula la p\u00e9rdida de actividad de la telomerasa a trav\u00e9s de modificaciones transcripcionales y postraduccionales de hTERT.<\/p><\/div>\n<div><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Moon, D. O., Kim, M. O., Choi, Y. H., Lee, H. G., Kim, N. D., &amp; Kim, G. Y. (2008). Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT.\u00a0FEBS letters, 582(23-24), 3367-3373. El gosipol es un compuesto polifen\u00f3lico originalmente aislado de la semilla de algod\u00f3n que se ha utilizado con \u00e9xito durante mucho [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45607","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El gosipol suprime la actividad de la telomerasa en las c\u00e9lulas leuc\u00e9micas humanas mediante la regulaci\u00f3n de hTERT&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45607\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El gosipol suprime la actividad de la telomerasa en las c\u00e9lulas leuc\u00e9micas humanas mediante la regulaci\u00f3n de hTERT&quot; -\" \/>\n<meta property=\"og:description\" content=\"Moon, D. O., Kim, M. O., Choi, Y. H., Lee, H. G., Kim, N. D., &amp; Kim, G. Y. (2008). Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT.\u00a0FEBS letters, 582(23-24), 3367-3373. El gosipol es un compuesto polifen\u00f3lico originalmente aislado de la semilla de algod\u00f3n que se ha utilizado con \u00e9xito durante mucho [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45607\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-11T23:30:20+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-12T22:03:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-WP0RX2zt4YY\/YCb54TF_B7I\/AAAAAAAAhvw\/w8Vht9BQQ7w64tqMvgnKb6pYxYPGp_JqACLcBGAsYHQ\/s0\/FEBS_letters.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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