{"id":45622,"date":"2021-02-20T00:30:52","date_gmt":"2021-02-19T23:30:52","guid":{"rendered":"https:\/\/rina.naturopatiadigital.eu\/?p=45622"},"modified":"2021-02-20T22:15:01","modified_gmt":"2021-02-20T21:15:01","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-papel-de-la-triptolida-en-la-proliferacion-celular-detencion-del-ciclo-celular-apoptosis-y-metilacion-de-histonas-en-celulas","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45622","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPapel de la  triptolida en la proliferaci\u00f3n celular, detenci\u00f3n del ciclo celular, apoptosis y metilaci\u00f3n de histonas en c\u00e9lulas de mieloma m\u00faltiple U266\u00bb"},"content":{"rendered":"<p><a href=\"https:\/\/1.bp.blogspot.com\/-hJIOPZAT3a8\/YDF12e2tPFI\/AAAAAAAAhxA\/3bhGUEIKd1UUJBZ1cbSuQuLbiytRW2FiwCLcBGAsYHQ\/s203\/European_Journal_of_Clinical_Pharmacology.jpg\"><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/1.bp.blogspot.com\/-hJIOPZAT3a8\/YDF12e2tPFI\/AAAAAAAAhxA\/3bhGUEIKd1UUJBZ1cbSuQuLbiytRW2FiwCLcBGAsYHQ\/s0\/European_Journal_of_Clinical_Pharmacology.jpg\" border=\"0\" data-original-height=\"203\" data-original-width=\"153\" \/><\/a>Zhao, F., Chen, Y., Zeng, L., Li, R., Zeng, R., Wen, L., &#8230; &amp; Zhang, C. (2010).\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S001429991000484X\">Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells<\/a>.\u00a0<i>European journal of pharmacology<\/i>, 646(1-3), 1-11.<\/p>\n<p>El mieloma m\u00faltiple es una neoplasia maligna hematol\u00f3gica incurable. Diferentes estudios demostraron la aparici\u00f3n de alteraciones gen\u00e9ticas y epigen\u00e9ticas en el mieloma m\u00faltiple. La metilaci\u00f3n de la histona lisina ha surgido como un cambio epigen\u00e9tico central en la organizaci\u00f3n de la cromatina eucariota con implicaciones de gran alcance para la regulaci\u00f3n de la proliferaci\u00f3n celular, la diferenciaci\u00f3n del tipo celular, la expresi\u00f3n g\u00e9nica, la estabilidad del genoma, el desarrollo general y la g\u00e9nesis del c\u00e1ncer. La triptolida es el principal ingrediente activo de los extractos de la hierba china Tripterygium wilfordii Hook.F (TwHF), y numerosos estudios han dilucidado su propiedad antitumoral.<\/p>\n<p>Nuestros experimentos descubrieron que triptolida inhib\u00eda la proliferaci\u00f3n de la l\u00ednea celular de mieloma m\u00faltiple U266 de una manera dependiente del tiempo y de la dosis, induc\u00eda la detenci\u00f3n del ciclo celular G2 \/ M y la apoptosis dependiente de caspasa.<\/p>\n<p>La triptolida podr\u00eda disminuir la expresi\u00f3n de la trimetilaci\u00f3n de las histonas H3K4, H3K27 y H3K36 en paralelo con las histonas metiltransferasas SMYD3, EZH2 y NSD1, respectivamente, que posiblemente fue el mecanismo anti-mieloma de la triptolida.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zhao, F., Chen, Y., Zeng, L., Li, R., Zeng, R., Wen, L., &#8230; &amp; Zhang, C. (2010).\u00a0Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.\u00a0European journal of pharmacology, 646(1-3), 1-11. El mieloma m\u00faltiple es una neoplasia maligna hematol\u00f3gica incurable. Diferentes estudios demostraron la aparici\u00f3n de alteraciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45622","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Papel de la triptolida en la proliferaci\u00f3n celular, detenci\u00f3n del ciclo celular, apoptosis y metilaci\u00f3n de histonas en c\u00e9lulas de mieloma m\u00faltiple U266&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45622\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Papel de la triptolida en la proliferaci\u00f3n celular, detenci\u00f3n del ciclo celular, apoptosis y metilaci\u00f3n de histonas en c\u00e9lulas de mieloma m\u00faltiple U266&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zhao, F., Chen, Y., Zeng, L., Li, R., Zeng, R., Wen, L., &#8230; &amp; Zhang, C. (2010).\u00a0Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.\u00a0European journal of pharmacology, 646(1-3), 1-11. El mieloma m\u00faltiple es una neoplasia maligna hematol\u00f3gica incurable. Diferentes estudios demostraron la aparici\u00f3n de alteraciones [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45622\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-19T23:30:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-20T21:15:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/1.bp.blogspot.com\/-hJIOPZAT3a8\/YDF12e2tPFI\/AAAAAAAAhxA\/3bhGUEIKd1UUJBZ1cbSuQuLbiytRW2FiwCLcBGAsYHQ\/s0\/European_Journal_of_Clinical_Pharmacology.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" 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