{"id":45742,"date":"2022-05-09T21:12:41","date_gmt":"2022-05-09T19:12:41","guid":{"rendered":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/?p=45742"},"modified":"2022-05-09T21:12:41","modified_gmt":"2022-05-09T19:12:41","slug":"area-de-conocimiento-tecnologia-naturopatica-o-naturopatia-aplicada-modulo-naturopatia-alimentaria-trofologia-la-melatonina-como-inhibidor-del-proteasoma-hay-alguna-evidencia-clinica","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45742","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLa melatonina como inhibidor del proteasoma. \u00bfHay alguna evidencia cl\u00ednica?\u00bb"},"content":{"rendered":"<p><span><img decoding=\"async\" class=\"size-full wp-image-45743 alignleft\" src=\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2022\/05\/Life_Science.gif\" alt=\"\" width=\"150\" height=\"200\" \/>Los inhibidores del proteasoma y la melatonina est\u00e1n \u00edntimamente involucrados en la regulaci\u00f3n de las principales prote\u00ednas de transducci\u00f3n de se\u00f1ales, incluidas p53, ciclina p27, factor de transcripci\u00f3n NF-\u03baB, factores apopt\u00f3ticos Bax y Bim, caspasa 3, caspasa 9, factor antiapopt\u00f3tico Bcl-2, TRAIL, NRF2 y factor de transcripci\u00f3n beta-catenina.\u00a0El hecho de que estos factores sean objetivos compartidos del inhibidor del proteasoma bortezomib y la melatonina sugiere la hip\u00f3tesis de trabajo de que la melatonina es un inhibidor del proteasoma.\u00a0Apoyando esta hip\u00f3tesis est\u00e1 el hecho de que la melatonina comparte con bortezomib una acci\u00f3n proapopt\u00f3tica selectiva en las c\u00e9lulas cancerosas.\u00a0Adem\u00e1s, tanto el bortezomib como la melatonina aumentan la sensibilidad de las c\u00e9lulas de glioma humano a la apoptosis inducida por TRAIL.\u00a0Recientemente se encontr\u00f3 evidencia directa de la inhibici\u00f3n de la melatonina del proteasoma en c\u00e9lulas de c\u00e1ncer renal humano.<\/span><\/p>\n<p><span>Planteamos la cuesti\u00f3n de si la melatonina debe investigarse en combinaci\u00f3n con inhibidores del proteasoma para reducir la toxicidad, reducir la resistencia a los medicamentos y mejorar la eficacia.\u00a0Esto puede ser particularmente v\u00e1lido para neoplasias malignas hematol\u00f3gicas en las que se ha demostrado que los inhibidores del proteasoma son \u00fatiles.\u00a0Son necesarios m\u00e1s estudios para determinar si las acciones de la melatonina sobre las v\u00edas de se\u00f1alizaci\u00f3n celular se deben a un efecto inhibidor directo sobre el n\u00facleo catal\u00edtico del proteasoma, a una acci\u00f3n inhibidora sobre la part\u00edcula reguladora del proteasoma o a un efecto indirecto de la melatonina. melatonina en la fosforilaci\u00f3n de factores transductores de se\u00f1ales.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Los inhibidores del proteasoma y la melatonina est\u00e1n \u00edntimamente involucrados en la regulaci\u00f3n de las principales prote\u00ednas de transducci\u00f3n de se\u00f1ales, incluidas p53, ciclina p27, factor de transcripci\u00f3n NF-\u03baB, factores apopt\u00f3ticos Bax y Bim, caspasa 3, caspasa 9, factor antiapopt\u00f3tico Bcl-2, TRAIL, NRF2 y factor de transcripci\u00f3n beta-catenina.\u00a0El hecho de que estos factores sean objetivos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-45742","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;La melatonina como inhibidor del proteasoma. \u00bfHay alguna evidencia cl\u00ednica?&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45742\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;La melatonina como inhibidor del proteasoma. \u00bfHay alguna evidencia cl\u00ednica?&quot; -\" \/>\n<meta property=\"og:description\" content=\"Los inhibidores del proteasoma y la melatonina est\u00e1n \u00edntimamente involucrados en la regulaci\u00f3n de las principales prote\u00ednas de transducci\u00f3n de se\u00f1ales, incluidas p53, ciclina p27, factor de transcripci\u00f3n NF-\u03baB, factores apopt\u00f3ticos Bax y Bim, caspasa 3, caspasa 9, factor antiapopt\u00f3tico Bcl-2, TRAIL, NRF2 y factor de transcripci\u00f3n beta-catenina.\u00a0El hecho de que estos factores sean objetivos [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45742\" \/>\n<meta property=\"article:published_time\" content=\"2022-05-09T19:12:41+00:00\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45742#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45742\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; 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