{"id":45748,"date":"2022-05-11T09:59:28","date_gmt":"2022-05-11T07:59:28","guid":{"rendered":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/?p=45748"},"modified":"2022-05-11T09:59:28","modified_gmt":"2022-05-11T07:59:28","slug":"area-de-conocimiento-tecnologia-naturopatica-o-naturopatia-aplicada-modulo-naturopatia-alimentaria-trofologia-la-vitamina-c-inactiva-el-inhibidor-del-proteasoma-ps-341-en-las-celulas-cancerosa","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45748","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria &#8211; TROFOLOGIA: \u00abLa vitamina C inactiva el inhibidor del proteasoma PS-341 en las c\u00e9lulas cancerosas humanas\u00bb"},"content":{"rendered":"<p><img decoding=\"async\" class=\"size-full wp-image-45749 alignleft\" src=\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2022\/05\/Clinical_Cancer-Research2.gif\" alt=\"\" width=\"117\" height=\"150\" \/>Zou, W., Yue, P., Lin, N., He, M., Zhou, Z., Lonial, S., &#8230; &amp; Sun, S. Y. (2006). <a href=\"https:\/\/aacrjournals.org\/clincancerres\/article\/12\/1\/273\/188497\/Vitamin-C-Inactivates-the-Proteasome-Inhibitor-PS\">Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells<\/a>.\u00a0<em>Clinical Cancer Research<\/em>,\u00a0<em>12<\/em>(1), 273-280.<\/p>\n<p><span><span class=\"goog-text-highlight\">PROPOSITO: PS-341 (bortezomib, Velcade), el primer inhibidor del proteosoma aprobado por la Administraci\u00f3n de Alimentos y Medicamentos para el tratamiento de pacientes con mieloma m\u00faltiple recidivante, induce la apoptosis en l\u00edneas celulares de c\u00e1ncer humano. <\/span>La vitamina C (\u00e1cido asc\u00f3rbico) es una vitamina esencial soluble en agua requerida para muchas funciones fisiol\u00f3gicas normales y debe obtenerse a trav\u00e9s de la dieta o tabletas suplementarias en humanos.\u00a0Aqu\u00ed estudiamos el efecto potencial de la vitamina C sobre la actividad anticancer\u00edgena de PS-341 en l\u00edneas celulares de c\u00e1ncer humano.<\/span><\/p>\n<p><span>DISE\u00d1O EXPERIMENTAL:\u00a0 Se estudiaron los efectos de la vitamina C en la inducci\u00f3n de apoptosis por PS-341 solo y por PS-341 combinado con el ligando inductor de apoptosis relacionado con el factor de necrosis tumoral. Adem\u00e1s, tambi\u00e9n se examinaron los efectos de la vitamina C y otros antioxidantes sobre la inhibici\u00f3n del proteosoma mediada por PS-341. Finalmente, se determin\u00f3 la interacci\u00f3n qu\u00edmica directa entre la vitamina C y el PS-341.<\/span><\/p>\n<p>RESULTADOS:<span>\u00a0La vitamina C anul\u00f3 la capacidad de PS-341 para inducir la apoptosis en varias l\u00edneas celulares de c\u00e1ncer humano, para inducir la detenci\u00f3n de G\u00a0<\/span><sub><span>2<\/span><\/sub><span>\u00a0-M y para aumentar la apoptosis inducida por el ligando inductor de apoptosis relacionado con el factor de necrosis tumoral.\u00a0Adem\u00e1s, la vitamina C suprimi\u00f3 la inhibici\u00f3n de la actividad del proteosoma mediada por PS-341. PS-341 por s\u00ed mismo no indujo la generaci\u00f3n de especies reactivas de ox\u00edgeno intracelular mientras que otros antioxidantes no lograron anular su actividad biol\u00f3gica.\u00a0Es importante destacar que detectamos una interacci\u00f3n qu\u00edmica directa entre la vitamina C y PS-341.<\/span><\/p>\n<p>CONCLUSION:<span>\u00a0la vitamina C se une directamente a PS-431, inactivando as\u00ed PS-341 independientemente de su actividad antioxidante.\u00a0Nuestros hallazgos sugieren que la vitamina C puede tener un efecto negativo en la actividad anticancer\u00edgena mediada por PS-341.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zou, W., Yue, P., Lin, N., He, M., Zhou, Z., Lonial, S., &#8230; &amp; Sun, S. Y. (2006). Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells.\u00a0Clinical Cancer Research,\u00a012(1), 273-280. PROPOSITO: PS-341 (bortezomib, Velcade), el primer inhibidor del proteosoma aprobado por la Administraci\u00f3n de Alimentos y Medicamentos para el tratamiento de pacientes con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-45748","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;La vitamina C inactiva el inhibidor del proteasoma PS-341 en las c\u00e9lulas cancerosas humanas&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45748\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria - TROFOLOGIA: &quot;La vitamina C inactiva el inhibidor del proteasoma PS-341 en las c\u00e9lulas cancerosas humanas&quot; -\" \/>\n<meta property=\"og:description\" content=\"Zou, W., Yue, P., Lin, N., He, M., Zhou, Z., Lonial, S., &#8230; &amp; Sun, S. Y. (2006). Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells.\u00a0Clinical Cancer Research,\u00a012(1), 273-280. 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