{"id":45884,"date":"2022-07-09T15:44:55","date_gmt":"2022-07-09T13:44:55","guid":{"rendered":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/?p=45884"},"modified":"2022-07-09T15:44:55","modified_gmt":"2022-07-09T13:44:55","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-el-efecto-de-la-pirroloquinolina-quinona-y-el-resveratrol-en-la-supervivencia-y-regeneracion-de-las-neuronas-granulares-del-cer","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45884","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\u00bb"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-45885 alignleft\" src=\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2022\/07\/Neuroscience_Letters-225x300.jpg\" alt=\"\" width=\"225\" height=\"300\" srcset=\"https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2022\/07\/Neuroscience_Letters-225x300.jpg 225w, https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2022\/07\/Neuroscience_Letters.jpg 576w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/>Shanan, N., GhasemiGharagoz, A., Abdel-Kader, R., &amp; Breitinger, H. G. (2019). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0304394018308474\">The effect of pyrroloquinoline quinone and resveratrol on the survival and regeneration of cerebellar granular neurons. <\/a><i>Neuroscience Letters<\/i>,\u00a0<i>694<\/i>, 192-197.<\/p>\n<p id=\"spar0030\"><span>La incapacidad del sistema nervioso central (SNC) para regenerarse despu\u00e9s de una lesi\u00f3n cerebral traum\u00e1tica (TBI) puede atribuirse a la muerte celular apopt\u00f3tica, al entorno extr\u00ednseco inhibitorio y a la capacidad limitada de las neuronas para regenerarse.\u00a0Por lo tanto, fomentar el potencial regenerativo intr\u00ednseco y minimizar la muerte de las c\u00e9lulas neuronales podr\u00eda ser un enfoque terap\u00e9utico prometedor.<\/span><\/p>\n<p id=\"spar0035\"><span>La pirroloquinolina quinona (PQQ) se inform\u00f3 anteriormente por su potencial neuroprotector y regenerador en los nervios perif\u00e9ricos.\u00a0Aqu\u00ed, investigamos la capacidad de PQQ para inducir el nuevo crecimiento de neuritas en un modelo de curaci\u00f3n de heridas en neuronas granulares cerebelosas cultivadas (CGN), una parte integral del circuito cerebeloso, como una de las \u00e1reas m\u00e1s afectadas despu\u00e9s de TBI.\u00a0El efecto neuroprotector tambi\u00e9n se examin\u00f3 utilizando\u00a0el modelo de apoptosis inducida por privaci\u00f3n de K\u00a0<\/span><sup><span>+ \/FCS en CGN.\u00a0<\/span><\/sup><span>El resveratrol (RVT), un promotor eficaz de la neuroprotecci\u00f3n y la regeneraci\u00f3n tanto a nivel central como perif\u00e9rico, tambi\u00e9n se investig\u00f3 por separado y en combinaci\u00f3n con PQQ para establecer un posible efecto sin\u00e9rgico.<\/span><\/p>\n<p id=\"spar0040\"><span>RVT (5 \u03bcM) y PQQ (0,5 \u03bcM) mostraron una tendencia a promover el nuevo crecimiento de neuritas en el ensayo de cicatrizaci\u00f3n de heridas, sin embargo, el efecto observado fue estad\u00edsticamente insignificante.\u00a0Se encontr\u00f3 que las concentraciones m\u00e1s altas de PQQ (1 y 2 \u03bcM) eran menos efectivas.\u00a0El resveratrol no afect\u00f3 la longitud de las neuritas en el cultivo de CGN;\u00a0sin embargo, aument\u00f3 significativamente el n\u00famero de CGN viables.\u00a0Por el efecto neuroprotector;\u00a0PQQ y RVT mostraron un aumento significativo en la supervivencia de las CGN despu\u00e9s de la privaci\u00f3n de cultivo con K\u00a0<\/span><sup><span>+<\/span><\/sup><span>\u00a0\/FCS.<\/span><\/p>\n<p id=\"spar0045\"><span>Por lo tanto, ambos compuestos mostraron una tendencia a apoyar el crecimiento de neuritas adem\u00e1s de un efecto neuroprotector significativo, pero no se detect\u00f3 ning\u00fan efecto sin\u00e9rgico.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shanan, N., GhasemiGharagoz, A., Abdel-Kader, R., &amp; Breitinger, H. G. (2019). The effect of pyrroloquinoline quinone and resveratrol on the survival and regeneration of cerebellar granular neurons. Neuroscience Letters,\u00a0694, 192-197. La incapacidad del sistema nervioso central (SNC) para regenerarse despu\u00e9s de una lesi\u00f3n cerebral traum\u00e1tica (TBI) puede atribuirse a la muerte celular apopt\u00f3tica, al entorno [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45884","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45884\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;El efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo&quot; -\" \/>\n<meta property=\"og:description\" content=\"Shanan, N., GhasemiGharagoz, A., Abdel-Kader, R., &amp; Breitinger, H. G. (2019). The effect of pyrroloquinoline quinone and resveratrol on the survival and regeneration of cerebellar granular neurons. Neuroscience Letters,\u00a0694, 192-197. La incapacidad del sistema nervioso central (SNC) para regenerarse despu\u00e9s de una lesi\u00f3n cerebral traum\u00e1tica (TBI) puede atribuirse a la muerte celular apopt\u00f3tica, al entorno [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45884\" \/>\n<meta property=\"article:published_time\" content=\"2022-07-09T13:44:55+00:00\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45884#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45884\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\u00bb\",\"datePublished\":\"2022-07-09T13:44:55+00:00\",\"dateModified\":\"2022-07-09T13:44:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45884\"},\"wordCount\":379,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=45884#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45884\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45884\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"El efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2022-07-09T13:44:55+00:00\",\"dateModified\":\"2022-07-09T13:44:55+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45884#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=45884\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=45884#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=45884","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\" -","og_description":"Shanan, N., GhasemiGharagoz, A., Abdel-Kader, R., &amp; Breitinger, H. G. (2019). The effect of pyrroloquinoline quinone and resveratrol on the survival and regeneration of cerebellar granular neurons. Neuroscience Letters,\u00a0694, 192-197. La incapacidad del sistema nervioso central (SNC) para regenerarse despu\u00e9s de una lesi\u00f3n cerebral traum\u00e1tica (TBI) puede atribuirse a la muerte celular apopt\u00f3tica, al entorno [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=45884","article_published_time":"2022-07-09T13:44:55+00:00","author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45884#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45884"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\u00bb","datePublished":"2022-07-09T13:44:55+00:00","dateModified":"2022-07-09T13:44:55+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45884"},"wordCount":379,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=45884#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45884","url":"https:\/\/rina.naturopatiadigital.eu\/?p=45884","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"El efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2022-07-09T13:44:55+00:00","dateModified":"2022-07-09T13:44:55+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45884#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=45884"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=45884#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abEl efecto de la pirroloquinolina quinona y el resveratrol en la supervivencia y regeneraci\u00f3n de las neuronas granulares del cerebelo\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/45884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=45884"}],"version-history":[{"count":1,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/45884\/revisions"}],"predecessor-version":[{"id":45886,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/45884\/revisions\/45886"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=45884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=45884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=45884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}