{"id":45969,"date":"2022-08-24T10:51:21","date_gmt":"2022-08-24T08:51:21","guid":{"rendered":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/?p=45969"},"modified":"2022-08-24T10:51:54","modified_gmt":"2022-08-24T08:51:54","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-puerarin-protege-las-celulas-%ce%b2-pancreaticas-en-ratones-diabeticos-obesos-a-traves-de-la-activacion-de-la-senalizacion-glp","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=45969","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abPuerarina protege las c\u00e9lulas \u03b2 pancre\u00e1ticas en ratones diab\u00e9ticos obesos a trav\u00e9s de la activaci\u00f3n de la se\u00f1alizaci\u00f3n GLP-1R\u00bb"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-45970 alignleft\" src=\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2022\/08\/Molecular_Endocrinology-226x300.gif\" alt=\"\" width=\"226\" height=\"300\" \/>Yang, L., Yao, D., Yang, H., Wei, Y., Peng, Y., Ding, Y., &amp; Shu, L. (2016). <a href=\"https:\/\/academic.oup.com\/mend\/article\/30\/3\/361\/2556481\">Puerarin protects pancreatic \u03b2-cells in obese diabetic mice via activation of GLP-1R signaling<\/a>.\u00a0<em>Molecular Endocrinology<\/em>,\u00a0<em>30<\/em>(3), 361-371.<\/p>\n<p>La diabetes se caracteriza por una p\u00e9rdida y disfunci\u00f3n de las c\u00e9lulas \u03b2.\u00a0La se\u00f1alizaci\u00f3n del receptor del p\u00e9ptido similar al glucag\u00f3n 1 (GLP-1R) juega un papel importante en la supervivencia y funci\u00f3n de las c\u00e9lulas \u03b2.\u00a0Es significativo identificar agentes prometedores de productos naturales que puedan activar la se\u00f1alizaci\u00f3n de GLP-1R.<\/p>\n<p>En este estudio, puerarina, una isoflavona de la dieta, se evalu\u00f3 sus efectos beneficiosos sobre la supervivencia de las c\u00e9lulas \u03b2 y la v\u00eda GLP-1R. Mostramos que puerarina redujo el aumento de peso corporal, normaliz\u00f3 la glucosa en sangre y mejor\u00f3 la tolerancia a la glucosa en dietas altas en grasas inducidas y <em>db\/db <\/em>ratones diab\u00e9ticos.<\/p>\n<p>Lo que es m\u00e1s importante, se observ\u00f3 un aumento de la masa de c\u00e9lulas \u03b2 y la proliferaci\u00f3n de c\u00e9lulas \u03b2, pero una disminuci\u00f3n de la apoptosis de las c\u00e9lulas \u03b2 en ratones diab\u00e9ticos tratados con puerarin, examinados mediante inmunotinci\u00f3n de secciones pancre\u00e1ticas de ratones.<\/p>\n<p>El efecto protector de puerarina sobre la supervivencia de las c\u00e9lulas \u03b2 se confirm\u00f3 en islotes de rat\u00f3n aislados tratados con glucosa alta.<\/p>\n<p>Otros estudios de mecanismos mostraron que el nivel circulante de GLP-1 en ratones no se vio afectado por puerarin. Sin embargo, puerarina mejor\u00f3 la se\u00f1alizaci\u00f3n de GLP-1R al regular al alza las expresiones de GLP-1R y la homeobox 1 pancre\u00e1tica y duodenal, lo que posteriormente condujo a la activaci\u00f3n de la prote\u00edna quinasa B (Akt) pero a la inactivaci\u00f3n de la caja forkhead O1 y promovi\u00f3 la supervivencia de las c\u00e9lulas \u03b2.<\/p>\n<p>El efecto protector de puerarina fue notablemente suprimido por Exendin(9\u201339), un antagonista de GLP-1R.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yang, L., Yao, D., Yang, H., Wei, Y., Peng, Y., Ding, Y., &amp; Shu, L. (2016). Puerarin protects pancreatic \u03b2-cells in obese diabetic mice via activation of GLP-1R signaling.\u00a0Molecular Endocrinology,\u00a030(3), 361-371. La diabetes se caracteriza por una p\u00e9rdida y disfunci\u00f3n de las c\u00e9lulas \u03b2.\u00a0La se\u00f1alizaci\u00f3n del receptor del p\u00e9ptido similar al glucag\u00f3n 1 (GLP-1R) juega [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-45969","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Puerarina protege las c\u00e9lulas \u03b2 pancre\u00e1ticas en ratones diab\u00e9ticos obesos a trav\u00e9s de la activaci\u00f3n de la se\u00f1alizaci\u00f3n GLP-1R&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=45969\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Puerarina protege las c\u00e9lulas \u03b2 pancre\u00e1ticas en ratones diab\u00e9ticos obesos a trav\u00e9s de la activaci\u00f3n de la se\u00f1alizaci\u00f3n GLP-1R&quot; -\" \/>\n<meta property=\"og:description\" content=\"Yang, L., Yao, D., Yang, H., Wei, Y., Peng, Y., Ding, Y., &amp; Shu, L. (2016). Puerarin protects pancreatic \u03b2-cells in obese diabetic mice via activation of GLP-1R signaling.\u00a0Molecular Endocrinology,\u00a030(3), 361-371. La diabetes se caracteriza por una p\u00e9rdida y disfunci\u00f3n de las c\u00e9lulas \u03b2.\u00a0La se\u00f1alizaci\u00f3n del receptor del p\u00e9ptido similar al glucag\u00f3n 1 (GLP-1R) juega [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=45969\" \/>\n<meta property=\"article:published_time\" content=\"2022-08-24T08:51:21+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-08-24T08:51:54+00:00\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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